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- W2170452261 endingPage "168" @default.
- W2170452261 startingPage "147" @default.
- W2170452261 abstract "Publisher Summary Antibiotics are found predominantly in the culture medium and not within the cells. This suggests that excretion is built into the biosynthetic process and, on present evidences, it is predicted that a mechanism to discourage reentry of the metabolite is an essential component in a majority of protective systems. Aurodox production by Streptomyces goldiniensis is self-limiting. The feedback effect is immediate and reversible. It is unrelated to the activity of aurodox as an inhibitor of prokaryotic protein synthesis since it is not reproduced by chloramphenicol or puromycin. However, structural analogs of aurodox, including some without antibiotic activity, mimic the effect. Mutants selected for tolerance to high levels of aurodox and able to produce greatly increased amounts of the antibiotic—are also released from the self-inhibition. In the chloramphenicol fermentation, addition of excess antibiotic inhibits further synthesis of the key enzyme, arylamine synthetase." @default.
- W2170452261 created "2016-06-24" @default.
- W2170452261 creator A5077845151 @default.
- W2170452261 date "1979-01-01" @default.
- W2170452261 modified "2023-10-14" @default.
- W2170452261 title "Antibiotic Tolerance in Producer Organisms" @default.
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