FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2170492741> ?p ?o ?g. }

• W2170492741 endingPage "276" @default.
• W2170492741 startingPage "262" @default.
• W2170492741 abstract "There is a worldwide increasing use of herbs which are often administered in combination with therapeutic drugs, raising the potential for herb-drug interactions. St John’s wort ( Hypericum perforatum) is one of the most commonly used herbal antidepressants. A literature search was performed using Medline (via Pubmed), Biological Abstracts, Cochrane Library, AMED, PsycINFO and Embase (all from their inception to September 2003) to identify known drug interaction with St John’s wort. The available data indicate that St John’s wort is a potent inducer of CYP 3A4 and P-glycoprotein (PgP), although it may inhibit or induce other CYPs, depending on the dose, route and duration of administration. Data from human studies and case reports indicate that St John’s wort decreased the blood concentrations of amitriptyline, cyclosporine, digoxin, fexofenadine, indinavir, methadone, midazolam, nevirapine, phenprocoumon, simvastatin, tacrolimus, theophylline and warfarin, whereas it did not alter the pharmacokinetics of carbamazepine, dextromethorphan, mycophenolic acid and pravastatin. St John’s wort decreased the plasma concentration of the active metabolite SN-38 in cancer patients receiving irinotecan treatment. St John’s wort did not alter the pharmacokinetics of tolbutamide, but increased the incidence of hypoglycaemia. Several cases have been reported that St John’s wort decreased cyclosporine blood concentration leading to organ rejection. St John’s wort caused breakthrough bleeding and unplanned pregnancies when used concomitantly with oral contraceptives. It also caused serotonin syndrome when coadministered with selective serotonin-reuptake inhibitors (e.g. sertaline and paroxetine). Both pharmacokinetic and pharmacodynamic components may play a role in these interactions. Because the potential interaction of St John’s wort with other drugs is a major safety concern, additional systematic research on herb-drug interactions and appropriate regulation in herbal safety and efficacy is needed." @default.
• W2170492741 created "2016-06-24" @default.
• W2170492741 creator A5027649946 @default.
• W2170492741 creator A5034181458 @default.
• W2170492741 creator A5067855113 @default.
• W2170492741 creator A5068439269 @default.
• W2170492741 creator A5087202351 @default.
• W2170492741 date "2004-06-01" @default.
• W2170492741 modified "2023-10-14" @default.
• W2170492741 title "Pharmacokinetic Interactions of Drugs with St John’s Wort" @default.
• W2170492741 cites W1505525797 @default.
• W2170492741 cites W1520746198 @default.
• W2170492741 cites W1584188206 @default.
• W2170492741 cites W1585209741 @default.
• W2170492741 cites W1587801042 @default.
• W2170492741 cites W1601980095 @default.
• W2170492741 cites W174715135 @default.
• W2170492741 cites W1956099131 @default.
• W2170492741 cites W1959962586 @default.
• W2170492741 cites W1964263053 @default.
• W2170492741 cites W1964465959 @default.
• W2170492741 cites W1968535758 @default.
• W2170492741 cites W1969753766 @default.
• W2170492741 cites W1973815871 @default.
• W2170492741 cites W1974655274 @default.
• W2170492741 cites W1979931282 @default.
• W2170492741 cites W1980416538 @default.
• W2170492741 cites W1982632416 @default.
• W2170492741 cites W1985339660 @default.
• W2170492741 cites W1985848091 @default.
• W2170492741 cites W1985984753 @default.
• W2170492741 cites W1986838867 @default.
• W2170492741 cites W1988612597 @default.
• W2170492741 cites W1988667204 @default.
• W2170492741 cites W1990771160 @default.
• W2170492741 cites W1993633682 @default.
• W2170492741 cites W1994461426 @default.
• W2170492741 cites W1997881702 @default.
• W2170492741 cites W1999041958 @default.
• W2170492741 cites W2000863273 @default.
• W2170492741 cites W2005123459 @default.
• W2170492741 cites W2005153538 @default.
• W2170492741 cites W2006998778 @default.
• W2170492741 cites W2007081167 @default.
• W2170492741 cites W2008263033 @default.
• W2170492741 cites W2008288621 @default.
• W2170492741 cites W2013028640 @default.
• W2170492741 cites W2013187174 @default.
• W2170492741 cites W2014548999 @default.
• W2170492741 cites W2015500397 @default.
• W2170492741 cites W2017577604 @default.
• W2170492741 cites W2021805364 @default.
• W2170492741 cites W2022545732 @default.
• W2170492741 cites W2027350291 @default.
• W2170492741 cites W2027713476 @default.
• W2170492741 cites W2029089301 @default.
• W2170492741 cites W2029225837 @default.
• W2170492741 cites W2033767311 @default.
• W2170492741 cites W2034432716 @default.
• W2170492741 cites W2035000881 @default.
• W2170492741 cites W2035091931 @default.
• W2170492741 cites W2035425265 @default.
• W2170492741 cites W2035989002 @default.
• W2170492741 cites W2041588278 @default.
• W2170492741 cites W2042128348 @default.
• W2170492741 cites W204724979 @default.
• W2170492741 cites W2048459638 @default.
• W2170492741 cites W2048648630 @default.
• W2170492741 cites W2050983949 @default.
• W2170492741 cites W2052085254 @default.
• W2170492741 cites W2054657245 @default.
• W2170492741 cites W2056510708 @default.
• W2170492741 cites W2062305479 @default.
• W2170492741 cites W2065209378 @default.
• W2170492741 cites W2067737110 @default.
• W2170492741 cites W2068185302 @default.
• W2170492741 cites W2068495809 @default.
• W2170492741 cites W2068634821 @default.
• W2170492741 cites W2070829073 @default.
• W2170492741 cites W2072046931 @default.
• W2170492741 cites W2072908280 @default.
• W2170492741 cites W2076853093 @default.
• W2170492741 cites W2076985436 @default.
• W2170492741 cites W2079896267 @default.
• W2170492741 cites W2080083635 @default.
• W2170492741 cites W2089926385 @default.
• W2170492741 cites W2090402650 @default.
• W2170492741 cites W2090632754 @default.
• W2170492741 cites W2091279473 @default.
• W2170492741 cites W2091509247 @default.
• W2170492741 cites W2097100227 @default.
• W2170492741 cites W2097502628 @default.
• W2170492741 cites W2097544991 @default.
• W2170492741 cites W2098142549 @default.
• W2170492741 cites W2098822886 @default.
• W2170492741 cites W2098867544 @default.
• W2170492741 cites W2101610746 @default.
• W2170492741 cites W2103035889 @default.

• next