FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2170492758> ?p ?o ?g. }

• W2170492758 endingPage "2668" @default.
• W2170492758 startingPage "2658" @default.
• W2170492758 abstract "Endothelial dysfunction begins in early CKD and contributes to cardiovascular mortality. HDL is considered antiatherogenic, but may have adverse vascular effects in cardiovascular disease, diabetes, and inflammatory conditions. The effect of renal failure on HDL properties is unknown. We studied the endothelial effects of HDL isolated from 82 children with CKD stages 2-5 (HDL(CKD)), who were free of underlying inflammatory diseases, diabetes, or active infections. Compared with HDL from healthy children, HDL(CKD) strongly inhibited nitric oxide production, promoted superoxide production, and increased vascular cell adhesion molecule-1 expression in human aortic endothelial cells, and reduced cholesterol efflux from macrophages. The effects on endothelial cells correlated with CKD grade, with the most profound changes induced by HDL from patients on dialysis, and partial recovery observed with HDL isolated after kidney transplantation. Furthermore, the in vitro effects on endothelial cells associated with increased aortic pulse wave velocity, carotid intima-media thickness, and circulating markers of endothelial dysfunction in patients. Symmetric dimethylarginine levels were increased in serum and fractions of HDL from children with CKD. In a longitudinal follow-up of eight children undergoing kidney transplantation, HDL-induced production of endothelial nitric oxide, superoxide, and vascular cell adhesion molecule-1 in vitro improved significantly at 3 months after transplantation, but did not reach normal levels. These results suggest that in children with CKD without concomitant disease affecting HDL function, HDL dysfunction begins in early CKD, progressing as renal function declines, and is partially reversed after kidney transplantation." @default.
• W2170492758 created "2016-06-24" @default.
• W2170492758 creator A5001127450 @default.
• W2170492758 creator A5012419218 @default.
• W2170492758 creator A5021067384 @default.
• W2170492758 creator A5021174934 @default.
• W2170492758 creator A5026749638 @default.
• W2170492758 creator A5027700446 @default.
• W2170492758 creator A5039316946 @default.
• W2170492758 creator A5049968808 @default.
• W2170492758 creator A5052560766 @default.
• W2170492758 creator A5056391477 @default.
• W2170492758 creator A5060888495 @default.
• W2170492758 creator A5068835718 @default.
• W2170492758 creator A5077230722 @default.
• W2170492758 creator A5080753934 @default.
• W2170492758 creator A5084249594 @default.
• W2170492758 creator A5084814066 @default.
• W2170492758 date "2014-05-22" @default.
• W2170492758 modified "2023-10-16" @default.
• W2170492758 title "HDL in Children with CKD Promotes Endothelial Dysfunction and an Abnormal Vascular Phenotype" @default.
• W2170492758 cites W122349615 @default.
• W2170492758 cites W1484549806 @default.
• W2170492758 cites W1976666387 @default.
• W2170492758 cites W1977312306 @default.
• W2170492758 cites W1980243442 @default.
• W2170492758 cites W2001619156 @default.
• W2170492758 cites W2017754180 @default.
• W2170492758 cites W2029046028 @default.
• W2170492758 cites W2030777261 @default.
• W2170492758 cites W2042256973 @default.
• W2170492758 cites W2050943665 @default.
• W2170492758 cites W2055258815 @default.
• W2170492758 cites W2055823448 @default.
• W2170492758 cites W2068797950 @default.
• W2170492758 cites W2073363749 @default.
• W2170492758 cites W2091063844 @default.
• W2170492758 cites W2094768566 @default.
• W2170492758 cites W2101912981 @default.
• W2170492758 cites W2105898297 @default.
• W2170492758 cites W2106422918 @default.
• W2170492758 cites W2111653033 @default.
• W2170492758 cites W2118825330 @default.
• W2170492758 cites W2122460944 @default.
• W2170492758 cites W2123960426 @default.
• W2170492758 cites W2126030700 @default.
• W2170492758 cites W2126475784 @default.
• W2170492758 cites W2135503869 @default.
• W2170492758 cites W2136326182 @default.
• W2170492758 cites W2139976637 @default.
• W2170492758 cites W2140480769 @default.
• W2170492758 cites W2145632027 @default.
• W2170492758 cites W2145802142 @default.
• W2170492758 cites W2157157967 @default.
• W2170492758 cites W2161924597 @default.
• W2170492758 cites W2164119832 @default.
• W2170492758 cites W2165758797 @default.
• W2170492758 cites W2165842273 @default.
• W2170492758 cites W2166199725 @default.
• W2170492758 cites W2169201903 @default.
• W2170492758 cites W2324841714 @default.
• W2170492758 doi "https://doi.org/10.1681/asn.2013111212" @default.
• W2170492758 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4214534" @default.
• W2170492758 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24854267" @default.
• W2170492758 hasPublicationYear "2014" @default.
• W2170492758 type Work @default.
• W2170492758 sameAs 2170492758 @default.
• W2170492758 citedByCount "93" @default.
• W2170492758 countsByYear W21704927582015 @default.
• W2170492758 countsByYear W21704927582016 @default.
• W2170492758 countsByYear W21704927582017 @default.
• W2170492758 countsByYear W21704927582018 @default.
• W2170492758 countsByYear W21704927582019 @default.
• W2170492758 countsByYear W21704927582020 @default.
• W2170492758 countsByYear W21704927582021 @default.
• W2170492758 countsByYear W21704927582022 @default.
• W2170492758 countsByYear W21704927582023 @default.
• W2170492758 crossrefType "journal-article" @default.
• W2170492758 hasAuthorship W2170492758A5001127450 @default.
• W2170492758 hasAuthorship W2170492758A5012419218 @default.
• W2170492758 hasAuthorship W2170492758A5021067384 @default.
• W2170492758 hasAuthorship W2170492758A5021174934 @default.
• W2170492758 hasAuthorship W2170492758A5026749638 @default.
• W2170492758 hasAuthorship W2170492758A5027700446 @default.
• W2170492758 hasAuthorship W2170492758A5039316946 @default.
• W2170492758 hasAuthorship W2170492758A5049968808 @default.
• W2170492758 hasAuthorship W2170492758A5052560766 @default.
• W2170492758 hasAuthorship W2170492758A5056391477 @default.
• W2170492758 hasAuthorship W2170492758A5060888495 @default.
• W2170492758 hasAuthorship W2170492758A5068835718 @default.
• W2170492758 hasAuthorship W2170492758A5077230722 @default.
• W2170492758 hasAuthorship W2170492758A5080753934 @default.
• W2170492758 hasAuthorship W2170492758A5084249594 @default.
• W2170492758 hasAuthorship W2170492758A5084814066 @default.
• W2170492758 hasBestOaLocation W21704927581 @default.
• W2170492758 hasConcept C123012128 @default.
• W2170492758 hasConcept C126322002 @default.
• W2170492758 hasConcept C134018914 @default.

• next