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• W2170495852 abstract "Summary C aenorhabditis elegans , originally isolated from soil, is a nematode used in various fields of biological research including host–microbe interaction. While bacterial pathogens responsible for human infections have been actively studied in C . elegans , very few bacterial species that provide beneficial effects on C . elegans have been reported. Here, we tested several bacterial soil isolates and then characterized the effects of L ysinibacillus sphaericus on C . elegans growth‐related phenotypes. Worms fed with L . sphaericus lived significantly longer than those growing with typical E scherichia coli OP 50. Early‐ and juvenile‐stage growth was also highly stimulated by L . sphaericus ; body size at 28 h post‐hatching was > 2 times larger than OP 50‐fed worms and L . sphaericus ‐fed worms moved through the larval stage development more rapidly than control worms. In addition, significantly elevated fertilization was observed in worms fed with L . sphaericus (∼ 8 h faster than the control group). Furthermore, growth with L . sphaericus resulted in the production of larger numbers of progeny than the control growth with OP 50. Worms grown with L . sphaericus were highly resistant to oxidative, osmotic and infection stresses. Together, our results reveal a novel mode of growth that involves healthy ageing of nematodes." @default.
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• W2170495852 date "2014-08-11" @default.
• W2170495852 modified "2023-09-26" @default.
• W2170495852 title "Extended longevity and robust early-stage development of<i>C</i><i>aenorhabditis elegans</i>by a soil microbe,<i>L</i><i>ysinibacillus sphaericus</i>" @default.
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• W2170495852 doi "https://doi.org/10.1111/1758-2229.12196" @default.
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