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• W2170508039 abstract "The measurement of extravascular lung water could aid the assessment and guide the management of potential lung donors following brain death. We therefore sought to validate a single indicator thermodilution extravascular lung water index (EVLWI-T) measurement using gravimetry and to assess the impact and clinical correlates of elevated EVLWI-T in potential lung donors and transplant recipients. In a prospective study, we measured serial EVLWI-T and haemodynamic and oxygenation data in 60 potential lung donors. To validate the EVLWI-T measurement, we measured in vivo thermodilution EVLWI (EVLWI-T) and gravimetric ex vivo EVLWI (EVLWI-G) in donor lungs rejected for transplant using the Holcroft and Trunkey modification of Pearce's method. We assessed the clinical correlates of elevated lung water and measured interleukin-8 and hepatocyte growth factor in bronchoalveolar lavage (BAL) fluid. The mean EVLWI-T (n = 60) was 9.7 (4.5) ml kg−1, being >7–10 ml kg−1 in 23/60 and >10 ml kg−1 in 16/60 potential donors. Donor lungs with EVLWI >10 ml kg−1 were more likely to be receiving norepinephrine (P = 0.04), have higher pulmonary capillary wedge pressures (P = 0.008), be unsuitable for transplantation (P = 0.007) and, if transplanted, have worse survival (P = 0.04). Lungs submitted to gravimetric analysis [n = 20 in 11 donors (9 double and 2 single)] had EVWLI-T of 10.8 (2.7) and EVLWI-G was 10.1 (2.5). There was a strong correlation between EVLW-T and EVLW-G (r = 0.7; P = 0.014), but EVLWI-T over-predicted the EVLWI-G by ∼1 ml kg−1 (EVLW-T = 1.05 × EVLW-G). Cytokine levels in BAL fluid were elevated. Elevated lung water is found in >50% of potential lung donors, predicts lung suitability for transplant and may adversely affect recipient outcome. Although EVLWI-T intrinsically overestimates gravimetric lung water, its measurement may aid the assessment of organ suitability. Lung water accumulation and the proinflammatory response may both be targets for modifying therapy." @default.
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• W2170508039 date "2012-12-31" @default.
• W2170508039 modified "2023-10-09" @default.
• W2170508039 title "Measurement of extravascular lung water following human brain death: implications for lung donor assessment and transplantation" @default.
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• W2170508039 doi "https://doi.org/10.1093/ejcts/ezs657" @default.
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