FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2170510081> ?p ?o ?g. }

• W2170510081 endingPage "1705" @default.
• W2170510081 startingPage "1697" @default.
• W2170510081 abstract "Latent membrane protein 2A (LMP2A) blocks B-cell receptor signal transduction in vitro by binding the Syk and Lyn protein tyrosine kinases. As well as blocking B-cell signal transduction, LMP2A has been shown to activate the phosphatidylinositol 3-kinase (PI3-K)/Akt pathway, which acts as a survival signal in both B cells and epithelial cells. Transforming growth factor beta 1 (TGF-beta 1) is a multifunctional cytokine that plays important roles in regulating cell growth and differentiation in many biological systems. The loss of the growth-inhibitory response to the TGF-beta 1 signal is found in many cancers and is widely thought to promote tumor development. In this study, we found that LMP2A induced the phosphorylation of Akt (serine 473) in Burkitt's lymphoma cell line Ramos and in gastric carcinoma cell line HSC-39 and partially enhanced cell viability following TGF-beta 1 treatment. In addition, LMP2A partially inhibited TGF-beta 1-induced DNA fragmentation and cleavage of poly(ADP-ribose) polymerase (PARP). In the presence of LY294002, an inhibitor of PI3-K, the LMP2A-mediated inhibitory effects on TGF-beta 1-induced DNA fragmentation and cleavage of PARP were alleviated. Furthermore, LMP2A did not alter the levels of expression of type I and type II TGF-beta 1 receptors. Taken together, these results suggest that LMP2A may inhibit TGF-beta 1-mediated apoptosis through activation of the PI3-K/Akt pathway." @default.
• W2170510081 created "2016-06-24" @default.
• W2170510081 creator A5008892117 @default.
• W2170510081 creator A5009157428 @default.
• W2170510081 date "2004-02-15" @default.
• W2170510081 modified "2023-10-14" @default.
• W2170510081 title "Latent Membrane Protein 2A Inhibits Transforming Growth Factor-β1-Induced Apoptosis through the Phosphatidylinositol 3-Kinase/Akt Pathway" @default.
• W2170510081 cites W134757124 @default.
• W2170510081 cites W1543538495 @default.
• W2170510081 cites W1591208477 @default.
• W2170510081 cites W1594237062 @default.
• W2170510081 cites W1658465453 @default.
• W2170510081 cites W1728415698 @default.
• W2170510081 cites W1779251134 @default.
• W2170510081 cites W1874292529 @default.
• W2170510081 cites W1942214720 @default.
• W2170510081 cites W1954313480 @default.
• W2170510081 cites W1967828766 @default.
• W2170510081 cites W1967912613 @default.
• W2170510081 cites W1982102756 @default.
• W2170510081 cites W1982925930 @default.
• W2170510081 cites W1984418041 @default.
• W2170510081 cites W1992310350 @default.
• W2170510081 cites W1992506198 @default.
• W2170510081 cites W1993546845 @default.
• W2170510081 cites W1999012962 @default.
• W2170510081 cites W2003918448 @default.
• W2170510081 cites W2009025470 @default.
• W2170510081 cites W2010298858 @default.
• W2170510081 cites W2018434369 @default.
• W2170510081 cites W2020391792 @default.
• W2170510081 cites W2023269331 @default.
• W2170510081 cites W2024128028 @default.
• W2170510081 cites W2024306318 @default.
• W2170510081 cites W2026389696 @default.
• W2170510081 cites W2029483765 @default.
• W2170510081 cites W2030573603 @default.
• W2170510081 cites W2033801757 @default.
• W2170510081 cites W2035147500 @default.
• W2170510081 cites W2036348838 @default.
• W2170510081 cites W2048121649 @default.
• W2170510081 cites W2050817546 @default.
• W2170510081 cites W2058138221 @default.
• W2170510081 cites W2079053367 @default.
• W2170510081 cites W2093628776 @default.
• W2170510081 cites W2097767970 @default.
• W2170510081 cites W2103031848 @default.
• W2170510081 cites W2111764891 @default.
• W2170510081 cites W2120326887 @default.
• W2170510081 cites W2127231390 @default.
• W2170510081 cites W2129061111 @default.
• W2170510081 cites W2129379081 @default.
• W2170510081 cites W2133516143 @default.
• W2170510081 cites W2135290063 @default.
• W2170510081 cites W2137035181 @default.
• W2170510081 cites W2141377612 @default.
• W2170510081 cites W2159147754 @default.
• W2170510081 cites W2159327683 @default.
• W2170510081 cites W2165787179 @default.
• W2170510081 cites W2168735060 @default.
• W2170510081 cites W2325707043 @default.
• W2170510081 cites W23306615 @default.
• W2170510081 cites W2620241325 @default.
• W2170510081 cites W2944088418 @default.
• W2170510081 cites W4256238889 @default.
• W2170510081 doi "https://doi.org/10.1128/jvi.78.4.1697-1705.2004" @default.
• W2170510081 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/369507" @default.
• W2170510081 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14747535" @default.
• W2170510081 hasPublicationYear "2004" @default.
• W2170510081 type Work @default.
• W2170510081 sameAs 2170510081 @default.
• W2170510081 citedByCount "113" @default.
• W2170510081 countsByYear W21705100812012 @default.
• W2170510081 countsByYear W21705100812013 @default.
• W2170510081 countsByYear W21705100812014 @default.
• W2170510081 countsByYear W21705100812015 @default.
• W2170510081 countsByYear W21705100812016 @default.
• W2170510081 countsByYear W21705100812017 @default.
• W2170510081 countsByYear W21705100812018 @default.
• W2170510081 countsByYear W21705100812019 @default.
• W2170510081 countsByYear W21705100812020 @default.
• W2170510081 countsByYear W21705100812021 @default.
• W2170510081 countsByYear W21705100812022 @default.
• W2170510081 countsByYear W21705100812023 @default.
• W2170510081 crossrefType "journal-article" @default.
• W2170510081 hasAuthorship W2170510081A5008892117 @default.
• W2170510081 hasAuthorship W2170510081A5009157428 @default.
• W2170510081 hasBestOaLocation W21705100812 @default.
• W2170510081 hasConcept C153911025 @default.
• W2170510081 hasConcept C175818844 @default.
• W2170510081 hasConcept C2778229498 @default.
• W2170510081 hasConcept C2780610907 @default.
• W2170510081 hasConcept C35174551 @default.
• W2170510081 hasConcept C42362537 @default.
• W2170510081 hasConcept C502942594 @default.
• W2170510081 hasConcept C62478195 @default.
• W2170510081 hasConcept C75217442 @default.
• W2170510081 hasConcept C86554907 @default.

• next