Matches in SemOpenAlex for { <https://semopenalex.org/work/W2170540560> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2170540560 abstract "Aim: ErbB2 is overexpressed in about 25% of breast cancers. It modulates myocardial development and function in the heart. Trastuzumab (T), an anti-ErbB2 inhibitor, has improved the prognosis of patients with breast cancer, but is related to an increased risk of asymptomatic left ventricular (LV) dysfunction (3–34%) and heart failure (2–4%). The mechanisms of T cardiotoxicity are not entirely known and can include changes in Ca2+ regulation related to blockade of ErbB2. Here, we aim at assessing whether ranolazine (RAN), diminishing intracellular Ca2+ through its inhibition of late Ina, blunts T cardiotoxicity in vivo. Methods: To evaluate cardiac function in vivo, fractional shortening (FS) and ejection fraction (EF) were measured by echocardiography M-Mode in C57BL6 mice, 2-4 mo old, pretreated with RAN (750mg/kg/day, a dose comparable to the one used in humans) per os for 3 days. RAN was then administered for additional 7 days, alone and together with T (2.25 mg/kg/day ip), according to our well established protocol. Results: In our in vivo studies, after 7 days with T, FS decreased to 49 ± 1.5%, p < 0.01 vs 60 ± 0.5% (sham), and EF to 81 + 2%, p < 0.01 vs 91 ± 1% (sham). RAN alone did not change FS (59 ± 2%) nor EF 89 ± 1%. Interestingly, in mice treated with RAN and T, RAN prevents the reduction of EF and FS vs T alone (FS was 58 ± 1%, EF was 90 ± 1%, p = 0.01 and p < 0.01 respectively). Conclusions: In our mouse model, T produces LV dysfunction and RAN blunts T cardiotoxic effects. We plan to test RAN as a cardioprotective agent with other target-therapy drugs in our experimental models and to define the mechanisms of cardioprotection." @default.
- W2170540560 created "2016-06-24" @default.
- W2170540560 creator A5000563587 @default.
- W2170540560 creator A5022823665 @default.
- W2170540560 creator A5026013433 @default.
- W2170540560 creator A5045173249 @default.
- W2170540560 creator A5050738877 @default.
- W2170540560 creator A5059187148 @default.
- W2170540560 creator A5062849333 @default.
- W2170540560 creator A5071559142 @default.
- W2170540560 creator A5075134017 @default.
- W2170540560 date "2014-09-01" @default.
- W2170540560 modified "2023-09-27" @default.
- W2170540560 title "Ranolazine Before and During Trastuzumab Treatment, Prevents Cardiotoxicity in Mice" @default.
- W2170540560 doi "https://doi.org/10.1093/annonc/mdu325.15" @default.
- W2170540560 hasPublicationYear "2014" @default.
- W2170540560 type Work @default.
- W2170540560 sameAs 2170540560 @default.
- W2170540560 citedByCount "0" @default.
- W2170540560 crossrefType "journal-article" @default.
- W2170540560 hasAuthorship W2170540560A5000563587 @default.
- W2170540560 hasAuthorship W2170540560A5022823665 @default.
- W2170540560 hasAuthorship W2170540560A5026013433 @default.
- W2170540560 hasAuthorship W2170540560A5045173249 @default.
- W2170540560 hasAuthorship W2170540560A5050738877 @default.
- W2170540560 hasAuthorship W2170540560A5059187148 @default.
- W2170540560 hasAuthorship W2170540560A5062849333 @default.
- W2170540560 hasAuthorship W2170540560A5071559142 @default.
- W2170540560 hasAuthorship W2170540560A5075134017 @default.
- W2170540560 hasBestOaLocation W21705405601 @default.
- W2170540560 hasConcept C111566952 @default.
- W2170540560 hasConcept C121608353 @default.
- W2170540560 hasConcept C126322002 @default.
- W2170540560 hasConcept C134018914 @default.
- W2170540560 hasConcept C150903083 @default.
- W2170540560 hasConcept C160704184 @default.
- W2170540560 hasConcept C164705383 @default.
- W2170540560 hasConcept C207001950 @default.
- W2170540560 hasConcept C2776802502 @default.
- W2170540560 hasConcept C2777910003 @default.
- W2170540560 hasConcept C2778198053 @default.
- W2170540560 hasConcept C2778233292 @default.
- W2170540560 hasConcept C2779177932 @default.
- W2170540560 hasConcept C2779786085 @default.
- W2170540560 hasConcept C29730261 @default.
- W2170540560 hasConcept C31258907 @default.
- W2170540560 hasConcept C41008148 @default.
- W2170540560 hasConcept C530470458 @default.
- W2170540560 hasConcept C71924100 @default.
- W2170540560 hasConcept C78085059 @default.
- W2170540560 hasConcept C86803240 @default.
- W2170540560 hasConceptScore W2170540560C111566952 @default.
- W2170540560 hasConceptScore W2170540560C121608353 @default.
- W2170540560 hasConceptScore W2170540560C126322002 @default.
- W2170540560 hasConceptScore W2170540560C134018914 @default.
- W2170540560 hasConceptScore W2170540560C150903083 @default.
- W2170540560 hasConceptScore W2170540560C160704184 @default.
- W2170540560 hasConceptScore W2170540560C164705383 @default.
- W2170540560 hasConceptScore W2170540560C207001950 @default.
- W2170540560 hasConceptScore W2170540560C2776802502 @default.
- W2170540560 hasConceptScore W2170540560C2777910003 @default.
- W2170540560 hasConceptScore W2170540560C2778198053 @default.
- W2170540560 hasConceptScore W2170540560C2778233292 @default.
- W2170540560 hasConceptScore W2170540560C2779177932 @default.
- W2170540560 hasConceptScore W2170540560C2779786085 @default.
- W2170540560 hasConceptScore W2170540560C29730261 @default.
- W2170540560 hasConceptScore W2170540560C31258907 @default.
- W2170540560 hasConceptScore W2170540560C41008148 @default.
- W2170540560 hasConceptScore W2170540560C530470458 @default.
- W2170540560 hasConceptScore W2170540560C71924100 @default.
- W2170540560 hasConceptScore W2170540560C78085059 @default.
- W2170540560 hasConceptScore W2170540560C86803240 @default.
- W2170540560 hasLocation W21705405601 @default.
- W2170540560 hasOpenAccess W2170540560 @default.
- W2170540560 hasPrimaryLocation W21705405601 @default.
- W2170540560 hasRelatedWork W1990826929 @default.
- W2170540560 hasRelatedWork W2019885117 @default.
- W2170540560 hasRelatedWork W2022987367 @default.
- W2170540560 hasRelatedWork W2040761961 @default.
- W2170540560 hasRelatedWork W2048738825 @default.
- W2170540560 hasRelatedWork W2086662523 @default.
- W2170540560 hasRelatedWork W2088335071 @default.
- W2170540560 hasRelatedWork W2098784576 @default.
- W2170540560 hasRelatedWork W2142019270 @default.
- W2170540560 hasRelatedWork W2315164206 @default.
- W2170540560 hasRelatedWork W2367414146 @default.
- W2170540560 hasRelatedWork W2462709398 @default.
- W2170540560 hasRelatedWork W312540422 @default.
- W2170540560 isParatext "false" @default.
- W2170540560 isRetracted "false" @default.
- W2170540560 magId "2170540560" @default.
- W2170540560 workType "article" @default.