FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2170554336> ?p ?o ?g. }

• W2170554336 endingPage "969" @default.
• W2170554336 startingPage "961" @default.
• W2170554336 abstract "Objective: To provide a clinically useful model illustrating the molecular aberrations affecting estrogen biosynthesis and metabolism in endometriosis and to discuss the therapeutic role of aromatase inhibitors.Design: Literature review.Result(s): Several molecular aberrations were found in endometriotic lesions (in contrast to eutopic endometrium) that favor increased local concentrations of E2. Endometriotic stromal cells aberrantly express aromatase, which converts C19 steroids to estrogens. Aromatase activity in these cells is stimulated by prostaglandin (PG)E2. Estrogen stimulates cyclooxygenase-2, giving rise to increased PGE2 formation. Thus, this positive feedback loop produces increasing quantities of E2 and PGE2 in endometriosis. The lack of aromatase expression in eutopic endometrium is maintained by binding of an inhibitory transcription factor, COUP-TF, to the aromatase promoter. In endometriosis, however, an aberrantly expressed factor, SF-1, displaces COUP-TF to bind to this same promoter and activates aromatase expression and thus local estrogen biosynthesis. Additionally, endometriotic glandular cells are deficient in 17β-hydroxysteroid dehydrogenase type 2, which converts E2 to estrone in the eutopic endometrium in response to P. Deficiency of this enzyme in endometriosis impairs the inactivation of E2 and may be a consequence of insensitivity to P.Conclusion(s): Molecular aberrations that increase local E2 concentrations may be important in the etiology of endometriosis. These molecules may be targeted to develop novel therapeutic strategies. The clinical relevance of aromatase expression in endometriosis was shown recently by the successful treatment of an unusually aggressive case of postmenopausal endometriosis with use of an aromatase inhibitor." @default.
• W2170554336 created "2016-06-24" @default.
• W2170554336 creator A5009298625 @default.
• W2170554336 creator A5089968384 @default.
• W2170554336 date "1999-12-01" @default.
• W2170554336 modified "2023-10-14" @default.
• W2170554336 title "Aromatase: a key molecule in the pathophysiology of endometriosis and a therapeutic target" @default.
• W2170554336 cites W1507820521 @default.
• W2170554336 cites W1512318310 @default.
• W2170554336 cites W1525342509 @default.
• W2170554336 cites W1845556393 @default.
• W2170554336 cites W1964185479 @default.
• W2170554336 cites W1970997691 @default.
• W2170554336 cites W1973331563 @default.
• W2170554336 cites W1978601816 @default.
• W2170554336 cites W1987557870 @default.
• W2170554336 cites W1988560484 @default.
• W2170554336 cites W1988709924 @default.
• W2170554336 cites W1989026955 @default.
• W2170554336 cites W1992084421 @default.
• W2170554336 cites W1993440441 @default.
• W2170554336 cites W1995895579 @default.
• W2170554336 cites W2000112356 @default.
• W2170554336 cites W2001895593 @default.
• W2170554336 cites W2002196249 @default.
• W2170554336 cites W2003474149 @default.
• W2170554336 cites W2012313039 @default.
• W2170554336 cites W2013857643 @default.
• W2170554336 cites W2015685869 @default.
• W2170554336 cites W2018335025 @default.
• W2170554336 cites W2028659031 @default.
• W2170554336 cites W2029344094 @default.
• W2170554336 cites W2029675056 @default.
• W2170554336 cites W2038138852 @default.
• W2170554336 cites W2039144212 @default.
• W2170554336 cites W2044526252 @default.
• W2170554336 cites W2053311013 @default.
• W2170554336 cites W2065460036 @default.
• W2170554336 cites W2065643273 @default.
• W2170554336 cites W2068935255 @default.
• W2170554336 cites W2073958848 @default.
• W2170554336 cites W2074687301 @default.
• W2170554336 cites W2079681040 @default.
• W2170554336 cites W2085603542 @default.
• W2170554336 cites W2089914596 @default.
• W2170554336 cites W2090871122 @default.
• W2170554336 cites W2092919766 @default.
• W2170554336 cites W2099590644 @default.
• W2170554336 cites W2102433678 @default.
• W2170554336 cites W2105925637 @default.
• W2170554336 cites W2109748444 @default.
• W2170554336 cites W2110828317 @default.
• W2170554336 cites W2126100083 @default.
• W2170554336 cites W2154239454 @default.
• W2170554336 cites W2168240431 @default.
• W2170554336 cites W2203749559 @default.
• W2170554336 cites W2322557386 @default.
• W2170554336 cites W2346020725 @default.
• W2170554336 cites W2346403664 @default.
• W2170554336 cites W2346708642 @default.
• W2170554336 cites W4248356941 @default.
• W2170554336 cites W4256380909 @default.
• W2170554336 doi "https://doi.org/10.1016/s0015-0282(99)00393-3" @default.
• W2170554336 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10593363" @default.
• W2170554336 hasPublicationYear "1999" @default.
• W2170554336 type Work @default.
• W2170554336 sameAs 2170554336 @default.
• W2170554336 citedByCount "217" @default.
• W2170554336 countsByYear W21705543362012 @default.
• W2170554336 countsByYear W21705543362013 @default.
• W2170554336 countsByYear W21705543362014 @default.
• W2170554336 countsByYear W21705543362015 @default.
• W2170554336 countsByYear W21705543362016 @default.
• W2170554336 countsByYear W21705543362017 @default.
• W2170554336 countsByYear W21705543362018 @default.
• W2170554336 countsByYear W21705543362019 @default.
• W2170554336 countsByYear W21705543362020 @default.
• W2170554336 countsByYear W21705543362021 @default.
• W2170554336 countsByYear W21705543362022 @default.
• W2170554336 countsByYear W21705543362023 @default.
• W2170554336 crossrefType "journal-article" @default.
• W2170554336 hasAuthorship W2170554336A5009298625 @default.
• W2170554336 hasAuthorship W2170554336A5089968384 @default.
• W2170554336 hasBestOaLocation W21705543361 @default.
• W2170554336 hasConcept C121608353 @default.
• W2170554336 hasConcept C126322002 @default.
• W2170554336 hasConcept C134018914 @default.
• W2170554336 hasConcept C16930146 @default.
• W2170554336 hasConcept C185592680 @default.
• W2170554336 hasConcept C2776166826 @default.
• W2170554336 hasConcept C2777164284 @default.
• W2170554336 hasConcept C2778504769 @default.
• W2170554336 hasConcept C2779522080 @default.
• W2170554336 hasConcept C2779742232 @default.
• W2170554336 hasConcept C502942594 @default.
• W2170554336 hasConcept C530470458 @default.
• W2170554336 hasConcept C71924100 @default.
• W2170554336 hasConcept C86803240 @default.

• next