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• W2170590325 abstract "Acoustic two-tone distortions are generated during non-linear mechanical amplification in the cochlea. Generation of the cubic distortion 2f1-f2 depends on asymmetric components of a non-linear transfer function whereas the difference tone f2-f1 relies on symmetric components. Therefore, a change of the operating point and hence the symmetry of the cochlear amplifier could be strongly reflected in the level of the f2-f1 distortion. To test this hypothesis, low-frequency tones (5 Hz) were used to bias the position of the cochlear partition in the gerbil. Phase-correlated changes of f2-f1 occurred at bias tone levels where there were almost no effects on 2f1-f2. Higher levels of the bias tone induced pronounced changes of both distortions. These results are qualitatively in good agreement with the results of a simulation in which the operating point of a Boltzman function was shifted. This function is similar to those used to describe outer hair cell WHO transduction. To influence OHC motility, salicylate was injected. It caused a decrease of the 2f1-f2 level and an increase in the level of f2-f1. Such reciprocal changes of both distortions, again, can be interpreted in terms of a shift of the operating point of the cochlear amplifier along a non-linear transfer characteristic. To directly influence the cochlear amplifier, DC current was injected into the scala media. Large negative currents ( > −2 μA) caused a pronounced decrease of 2f1-f2 ( > 15 dB) and positive currents had more complex effects with increasing and/or decreasing 2f1-f2 distortion level. The effects were time and primary level dependent. Changes of f2-f1 for DC currents > /vbμ 2A/vb were in most cases larger compared to 2f1-f2 and reversed for certain primary levels. The current effects probably result from a combination of changing the endocochlear potential and shifting the operating point along a non-linear transfer function." @default.
• W2170590325 created "2016-06-24" @default.
• W2170590325 creator A5028473386 @default.
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• W2170590325 date "1996-09-01" @default.
• W2170590325 modified "2023-09-27" @default.
• W2170590325 title "The acoustic two-tone distortions 2f1-f2 and f2-f1 and their possible relation to changes in the operating point of the cochlear amplifier" @default.
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• W2170590325 doi "https://doi.org/10.1016/0378-5955(96)00083-4" @default.
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