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- W2170601889 abstract "Clinical significance of interleukin (IL)-6 in cancer metastasis to bone: potential of anti-IL-6 therapies Ken Tawara, Julia T Oxford, Cheryl L JorcykDepartment of Biological Sciences, Boise State University, Boise, ID, USAAbstract: Metastatic events to the bone occur frequently in numerous cancer types such as breast, prostate, lung, and renal carcinomas, melanoma, neuroblastoma, and multiple myeloma. Accumulating evidence suggests that the inflammatory cytokine interleukin (IL)-6 is frequently upregulated and is implicated in the ability of cancer cells to metastasize to bone. IL-6 is able to activate various cell signaling cascades that include the STAT (signal transducer and activator of transcription) pathway, the PI3K (phosphatidylinositol-3 kinase) pathway, and the MAPK (mitogen-activated protein kinase) pathway. Activation of these pathways may explain the ability of IL-6 to mediate various aspects of normal and pathogenic bone remodeling, inflammation, cell survival, proliferation, and pro-tumorigenic effects. This review article will discuss the role of IL-6: 1) in bone metabolism, 2) in cancer metastasis to bone, 3) in cancer prognosis, and 4) as potential therapies for metastatic bone cancer.Keywords: interleukin-6, bone metastasis, cancer, osteoclastogenesis, osteoclast, osteoblast" @default.
- W2170601889 created "2016-06-24" @default.
- W2170601889 creator A5028259526 @default.
- W2170601889 creator A5039634836 @default.
- W2170601889 creator A5063171473 @default.
- W2170601889 date "2011-05-01" @default.
- W2170601889 modified "2023-10-18" @default.
- W2170601889 title "Clinical significance of interleukin (IL)-6 in cancer metastasis to bone: potential of anti-IL-6 therapies" @default.
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