FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2170604221> ?p ?o ?g. }

• W2170604221 endingPage "12472" @default.
• W2170604221 startingPage "12467" @default.
• W2170604221 abstract "How the ribosome-bound nascent chain folds to assume its functional tertiary structure remains a central puzzle in biology. In contrast to refolding of a denatured protein, cotranslational folding is complicated by the vectorial nature of nascent chains, the frequent ribosome pausing, and the cellular crowdedness. Here, we present a strategy called folding-associated cotranslational sequencing that enables monitoring of the folding competency of nascent chains during elongation at codon resolution. By using an engineered multidomain fusion protein, we demonstrate an efficient cotranslational folding immediately after the emergence of the full domain sequence. We also apply folding-associated cotranslational sequencing to track cotranslational folding of hemagglutinin in influenza A virus-infected cells. In contrast to sequential formation of distinct epitopes, the receptor binding domain of hemagglutinin follows a global folding route by displaying two epitopes simultaneously when the full sequence is available. Our results provide direct evidence of domain-wise global folding that occurs cotranslationally in mammalian cells." @default.
• W2170604221 created "2016-06-24" @default.
• W2170604221 creator A5006342964 @default.
• W2170604221 creator A5028918974 @default.
• W2170604221 creator A5030635221 @default.
• W2170604221 creator A5053334268 @default.
• W2170604221 creator A5058102315 @default.
• W2170604221 creator A5070440610 @default.
• W2170604221 creator A5086623350 @default.
• W2170604221 date "2012-07-16" @default.
• W2170604221 modified "2023-10-12" @default.
• W2170604221 title "Monitoring cotranslational protein folding in mammalian cells at codon resolution" @default.
• W2170604221 cites W1545743851 @default.
• W2170604221 cites W1976873642 @default.
• W2170604221 cites W1982785263 @default.
• W2170604221 cites W1986720579 @default.
• W2170604221 cites W1992386603 @default.
• W2170604221 cites W2004477764 @default.
• W2170604221 cites W2007110714 @default.
• W2170604221 cites W2024069417 @default.
• W2170604221 cites W2025118356 @default.
• W2170604221 cites W2047511409 @default.
• W2170604221 cites W2065248572 @default.
• W2170604221 cites W2071849521 @default.
• W2170604221 cites W2073352378 @default.
• W2170604221 cites W2075839343 @default.
• W2170604221 cites W2079517684 @default.
• W2170604221 cites W2085628457 @default.
• W2170604221 cites W2102335249 @default.
• W2170604221 cites W2108926259 @default.
• W2170604221 cites W2112501830 @default.
• W2170604221 cites W2133968430 @default.
• W2170604221 cites W2145471097 @default.
• W2170604221 cites W2160675155 @default.
• W2170604221 doi "https://doi.org/10.1073/pnas.1208138109" @default.
• W2170604221 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3411940" @default.
• W2170604221 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22802618" @default.
• W2170604221 hasPublicationYear "2012" @default.
• W2170604221 type Work @default.
• W2170604221 sameAs 2170604221 @default.
• W2170604221 citedByCount "61" @default.
• W2170604221 countsByYear W21706042212012 @default.
• W2170604221 countsByYear W21706042212013 @default.
• W2170604221 countsByYear W21706042212014 @default.
• W2170604221 countsByYear W21706042212015 @default.
• W2170604221 countsByYear W21706042212016 @default.
• W2170604221 countsByYear W21706042212017 @default.
• W2170604221 countsByYear W21706042212018 @default.
• W2170604221 countsByYear W21706042212019 @default.
• W2170604221 countsByYear W21706042212020 @default.
• W2170604221 countsByYear W21706042212021 @default.
• W2170604221 countsByYear W21706042212022 @default.
• W2170604221 countsByYear W21706042212023 @default.
• W2170604221 crossrefType "journal-article" @default.
• W2170604221 hasAuthorship W2170604221A5006342964 @default.
• W2170604221 hasAuthorship W2170604221A5028918974 @default.
• W2170604221 hasAuthorship W2170604221A5030635221 @default.
• W2170604221 hasAuthorship W2170604221A5053334268 @default.
• W2170604221 hasAuthorship W2170604221A5058102315 @default.
• W2170604221 hasAuthorship W2170604221A5070440610 @default.
• W2170604221 hasAuthorship W2170604221A5086623350 @default.
• W2170604221 hasBestOaLocation W21706042211 @default.
• W2170604221 hasConcept C104317684 @default.
• W2170604221 hasConcept C105580179 @default.
• W2170604221 hasConcept C119599485 @default.
• W2170604221 hasConcept C127413603 @default.
• W2170604221 hasConcept C138626823 @default.
• W2170604221 hasConcept C149364088 @default.
• W2170604221 hasConcept C159654299 @default.
• W2170604221 hasConcept C195616568 @default.
• W2170604221 hasConcept C199229279 @default.
• W2170604221 hasConcept C204328495 @default.
• W2170604221 hasConcept C2776545253 @default.
• W2170604221 hasConcept C2778692840 @default.
• W2170604221 hasConcept C54355233 @default.
• W2170604221 hasConcept C55493867 @default.
• W2170604221 hasConcept C67705224 @default.
• W2170604221 hasConcept C70721500 @default.
• W2170604221 hasConcept C86803240 @default.
• W2170604221 hasConcept C88478588 @default.
• W2170604221 hasConcept C95444343 @default.
• W2170604221 hasConceptScore W2170604221C104317684 @default.
• W2170604221 hasConceptScore W2170604221C105580179 @default.
• W2170604221 hasConceptScore W2170604221C119599485 @default.
• W2170604221 hasConceptScore W2170604221C127413603 @default.
• W2170604221 hasConceptScore W2170604221C138626823 @default.
• W2170604221 hasConceptScore W2170604221C149364088 @default.
• W2170604221 hasConceptScore W2170604221C159654299 @default.
• W2170604221 hasConceptScore W2170604221C195616568 @default.
• W2170604221 hasConceptScore W2170604221C199229279 @default.
• W2170604221 hasConceptScore W2170604221C204328495 @default.
• W2170604221 hasConceptScore W2170604221C2776545253 @default.
• W2170604221 hasConceptScore W2170604221C2778692840 @default.
• W2170604221 hasConceptScore W2170604221C54355233 @default.
• W2170604221 hasConceptScore W2170604221C55493867 @default.
• W2170604221 hasConceptScore W2170604221C67705224 @default.
• W2170604221 hasConceptScore W2170604221C70721500 @default.
• W2170604221 hasConceptScore W2170604221C86803240 @default.

• next