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• W2170620123 abstract "The aim of the study was to characterise gastro-oesophageal reflux (GOR) in idiopathic pulmonary fibrosis (IPF). 40 consecutive IPF patients underwent pulmonary high-resolution computed tomography (HRCT) scan and impedance-pH monitoring while off antisecretory therapy. The presence of pulmonary fibrosis was assessed using validated HRCT scores. Reflux features included distal oesophageal acid exposure, number of acid/weakly acidic reflux episodes and their proximal migration. 40 consecutive patients with interstitial lung disease other than IPF (non-IPF patients) and 50 healthy volunteers were also enrolled. IPF patients had significantly higher (p<0.01) oesophageal acid exposure (median (interquartile range (IQR)) 9.25 (4.7–15.4)% <i>versus</i> 3.3 (1.4–7.4)% <i>versus</i> 0.7 (0.2–4.2)%, number of acid (median (IQR) 45 (23–55) <i>versus</i> 32 (19–44) <i>versus</i> 18 (10–31)), weakly acidic (median (IQR) 34 (19–43) <i>versus</i> 21 (11–33) <i>versus</i> 18 (15–28)) and proximal reflux (median (IQR) 51 (26.5–65.5) <i>versus</i> 20 (9.5–34.5) <i>versus</i> 9 (5–20)) events compared to non-IPF patients and healthy volunteers, respectively. Pulmonary fibrosis HRCT scores correlated well with reflux episodes in both the distal (r²=0.567) and proximal (r²=0.6323) oesophagus. Patients with IPF had more bile acids and pepsin (p<0.03) in bronchoalveolar lavage fluid (BALF) (62% and 67%, respectively) and saliva (61% and 68%, respectively) than non-IPF patients (25% and 25% in BALF, and 33% and 36%, respectively, in saliva) and controls (0% and 0% in BALF and saliva, respectively). Acid GOR is common in IPF, but weakly acidic GOR may also occur. Patients with IPF had a risk of pulmonary aspiration of gastric contents. Outcome studies with intense antireflux therapy are needed." @default.
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• W2170620123 date "2013-03-07" @default.
• W2170620123 modified "2023-10-16" @default.
• W2170620123 title "Gastro-oesophageal reflux and gastric aspiration in idiopathic pulmonary fibrosis patients" @default.
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• W2170620123 doi "https://doi.org/10.1183/09031936.00101212" @default.
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