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- W2170620574 abstract "Disparities in heart transplantation (HTx) outcomes between African Americans (AA) and Caucasian American (CA) recipients are known. The role of genetics in predicting survival after HTx has not been established. We investigated impact of genetic variants on survival of AA and CA adult HTx recipients using Imuno-Beadchip® gene platform. For 260 adults (CA 207 and AA 53) transplanted between 2/1991 and 6/2011, association between single nucleotide polymorphism (SNP) and survival was determined using banked cells. GRS using significant SNPs (p ≤1.0E-04) was calculated. Ten year survival was estimated by Kaplan-Meier for high(≥50 percentile) versus low(<50 percentile)GRS adjusting for top 2 principle components and clinical factors. Clinical factors were analyzed by Cox proportional hazards. AA and CA with low GRS had comparable survival (p = 0.12). For high GRS, AA demonstrated significantly worse survival than CA (p = 0.001). For high GRS patients, AA Ischemic time (p = 0.01. HR 0.97) and CA female gender ( p =0.03, HR0.97) were significant. Genetic variants pre-determine survival in HTx. For patients with high GRS score, AA had significantly lower survival compared to CA. Larger studies are needed to validate these data." @default.
- W2170620574 created "2016-06-24" @default.
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- W2170620574 date "2015-04-01" @default.
- W2170620574 modified "2023-09-27" @default.
- W2170620574 title "Genetic Risk Score (GRS) Predicts Worse Survival in African American Heart Transplant Recipients at 10 Years" @default.
- W2170620574 doi "https://doi.org/10.1016/j.healun.2015.01.304" @default.
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