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- W2170627809 abstract "Mycobacterium ulcerans is the causative agent of the Buruli ulcers in humans. This disease is a devastating necrotic disease of the subcutaneous tissue. Currently there is no vaccine to prevent the Buruli ulcers. The gene sequence of this extremely pathogenic organism has recently been identified. In the present study an attempt has been made to analyze the structural aspects of the interactions of the SigL protein from Mycobacterium ulcerans with its promoter DNA sequence. This interaction is vital for the regulation of the expression of Mycobacterium ulcerans genes. The tertiary structure of the protein has been predicted from the primary structure and analyzed. SigL protein has distinct helix-turn-helix DNA binding motif. It is compared to other members of the DNA binding proteins. The modeled structure of SigL has been used to predict the favourable binding interactions of the protein with its promoter DNA, which are responsible for the gene expressions in the organism. These interactions have been used to predict the mechanism of the process. Since this is the first structural work regarding the interactions of SigL protein and its promoter DNA, this study may contribute in the realm of structure based drug design approaches against this immensely pathogenic organism." @default.
- W2170627809 created "2016-06-24" @default.
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- W2170627809 date "2008-01-01" @default.
- W2170627809 modified "2023-09-27" @default.
- W2170627809 title "Study of the interactions between SigL and its associated factor from the pathogenic Mycobacterium ulcerans" @default.
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