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- W2170627826 abstract "Skeletal muscle mass is in a constant state of turnover, and atrophy is the result of a shift in the balance of muscle protein synthesis and breakdown resulting in net muscle protein loss. Total disuse of skeletal muscle quickly leads to muscle atrophy and loss of strength, and this has been repeatedly demonstrated in studies employing bed rest and lower limb immobilisation methodologies in young healthy participants. Fewer studies have focused on older participants (>65 years of age), but those that have provide evidence that advancing age brings increased vulnerability to rapid and marked loss of muscle size and strength during period of total muscle unloading. Increased systemic inflammation and reduced protein synthetic responses to protein feeding and muscle contraction might influence the severity of muscle protein loss during periods of total unloading compared with younger individuals. Less extreme reductions in muscle loading (e.g., 2 weeks of reducing daily ambulation to <1500 steps/day) have also been shown to result in decreases in muscle mass. This step-reduction model may be more relevant than total bed rest or limb immobilisation for examining real-world scenarios that present a physiological challenge to the maintenance of skeletal muscle mass in older individuals." @default.
- W2170627826 created "2016-06-24" @default.
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- W2170627826 creator A5009470082 @default.
- W2170627826 creator A5030011946 @default.
- W2170627826 creator A5069421692 @default.
- W2170627826 date "2015-10-27" @default.
- W2170627826 modified "2023-10-02" @default.
- W2170627826 title "A reduced activity model: a relevant tool for the study of ageing muscle" @default.
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- W2170627826 cites W15005882 @default.
- W2170627826 cites W1517178982 @default.
- W2170627826 cites W1548759563 @default.
- W2170627826 cites W1573938781 @default.
- W2170627826 cites W1585427103 @default.
- W2170627826 cites W1586159393 @default.
- W2170627826 cites W1645045438 @default.
- W2170627826 cites W1838896829 @default.
- W2170627826 cites W1930278141 @default.
- W2170627826 cites W1945984274 @default.
- W2170627826 cites W1964986236 @default.
- W2170627826 cites W1968601230 @default.
- W2170627826 cites W1969627119 @default.
- W2170627826 cites W1972557285 @default.
- W2170627826 cites W1981105458 @default.
- W2170627826 cites W1982111510 @default.
- W2170627826 cites W1989280491 @default.
- W2170627826 cites W1990435249 @default.
- W2170627826 cites W1992586784 @default.
- W2170627826 cites W1997591046 @default.
- W2170627826 cites W1997988119 @default.
- W2170627826 cites W2014329618 @default.
- W2170627826 cites W2016420804 @default.
- W2170627826 cites W2020203688 @default.
- W2170627826 cites W2022693088 @default.
- W2170627826 cites W2023470228 @default.
- W2170627826 cites W2024319789 @default.
- W2170627826 cites W2024393219 @default.
- W2170627826 cites W2024411090 @default.
- W2170627826 cites W2027623349 @default.
- W2170627826 cites W2030136924 @default.
- W2170627826 cites W2030920333 @default.
- W2170627826 cites W2033504603 @default.
- W2170627826 cites W2036067910 @default.
- W2170627826 cites W2036145275 @default.
- W2170627826 cites W2036833431 @default.
- W2170627826 cites W2037048755 @default.
- W2170627826 cites W2045577106 @default.
- W2170627826 cites W2050253752 @default.
- W2170627826 cites W2051446390 @default.
- W2170627826 cites W2053533379 @default.
- W2170627826 cites W2055982145 @default.
- W2170627826 cites W2056991226 @default.
- W2170627826 cites W2065285042 @default.
- W2170627826 cites W2068682682 @default.
- W2170627826 cites W2085643386 @default.
- W2170627826 cites W2085792315 @default.
- W2170627826 cites W2087635405 @default.
- W2170627826 cites W2087755307 @default.
- W2170627826 cites W2099210995 @default.
- W2170627826 cites W2101802733 @default.
- W2170627826 cites W2102990980 @default.
- W2170627826 cites W2104683776 @default.
- W2170627826 cites W2110093017 @default.
- W2170627826 cites W2110943180 @default.
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- W2170627826 cites W2133915158 @default.
- W2170627826 cites W2137092614 @default.
- W2170627826 cites W2137618038 @default.
- W2170627826 cites W2137646952 @default.
- W2170627826 cites W2139656274 @default.
- W2170627826 cites W2140626550 @default.
- W2170627826 cites W2141545521 @default.
- W2170627826 cites W2142309903 @default.
- W2170627826 cites W2143745192 @default.
- W2170627826 cites W2147832910 @default.
- W2170627826 cites W2149349511 @default.
- W2170627826 cites W2150766174 @default.
- W2170627826 cites W2159234192 @default.
- W2170627826 cites W2159264607 @default.
- W2170627826 cites W2159569431 @default.
- W2170627826 cites W2159802435 @default.
- W2170627826 cites W2162441719 @default.
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- W2170627826 doi "https://doi.org/10.1007/s10522-015-9613-9" @default.
- W2170627826 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4889637" @default.
- W2170627826 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26506931" @default.
- W2170627826 hasPublicationYear "2015" @default.
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