FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2170646712> ?p ?o ?g. }

• W2170646712 endingPage "1481" @default.
• W2170646712 startingPage "1472" @default.
• W2170646712 abstract "Insulin resistance represents an independent risk factor for metabolic and cardiovascular diseases. Researchers have been interested in identifying active harmless compounds, as many insulin-sensitizing drugs have shown unwanted side-effects. It has been demonstrated that anthocyanins and one of their representative metabolites, protocatechuic acid (PCA), ameliorate hyperglycemia, and insulin sensitivity. This study investigated the mechanism of action of PCA responsible for the glucose uptake upregulation.In human visceral adipocytes, PCA stimulated insulin receptor substrate-1 (IRS-1) tyrosine phosphorylation (+40% with respect to untreated cells) and the downstream events, i.e. phosphoinositide 3-kinase binding to IRS-1 and Akt phosphorylation (+100%, +180%, respectively, with respect to untreated cells). The insulin-like activity of PCA seemed to be mediated by insulin receptor since by inhibiting its autophosphorylation, the PCA effects were completely abolished. Furthermore, PCA was able to activate adenosine monophosphate-activated protein kinase, a serine/threonine kinase whose activation elicits insulin-sensitizing effects.This study showed that PCA stimulates the insulin signaling pathway in human adipocytes increasing GLUT4 translocation and glucose uptake. Decreasing insulin resistance is a most desirable aim to be reached for an effective therapeutic/preventive action against metabolic syndrome and type 2 diabetes. Identifying specific food/food components able to improve glucose metabolism can offer an attractive, novel, and economical strategy." @default.
• W2170646712 created "2016-06-24" @default.
• W2170646712 creator A5015449382 @default.
• W2170646712 creator A5032583036 @default.
• W2170646712 creator A5039048300 @default.
• W2170646712 creator A5042806883 @default.
• W2170646712 creator A5057125332 @default.
• W2170646712 creator A5057379888 @default.
• W2170646712 creator A5064923590 @default.
• W2170646712 creator A5065661629 @default.
• W2170646712 creator A5074277658 @default.
• W2170646712 creator A5074687051 @default.
• W2170646712 date "2015-05-29" @default.
• W2170646712 modified "2023-10-18" @default.
• W2170646712 title "Protocatechuic acid activates key components of insulin signaling pathway mimicking insulin activity" @default.
• W2170646712 cites W1752475296 @default.
• W2170646712 cites W1904908546 @default.
• W2170646712 cites W1918621175 @default.
• W2170646712 cites W1969663381 @default.
• W2170646712 cites W1972590376 @default.
• W2170646712 cites W1973372369 @default.
• W2170646712 cites W1978975287 @default.
• W2170646712 cites W1981651253 @default.
• W2170646712 cites W1982563578 @default.
• W2170646712 cites W1987218036 @default.
• W2170646712 cites W1987522063 @default.
• W2170646712 cites W1997542501 @default.
• W2170646712 cites W1997680261 @default.
• W2170646712 cites W2002807148 @default.
• W2170646712 cites W2011979785 @default.
• W2170646712 cites W2017895621 @default.
• W2170646712 cites W2023536393 @default.
• W2170646712 cites W2037980300 @default.
• W2170646712 cites W2039129100 @default.
• W2170646712 cites W2042934883 @default.
• W2170646712 cites W2050728234 @default.
• W2170646712 cites W2052178993 @default.
• W2170646712 cites W2057131871 @default.
• W2170646712 cites W2057218469 @default.
• W2170646712 cites W2063928557 @default.
• W2170646712 cites W2070119291 @default.
• W2170646712 cites W2075481696 @default.
• W2170646712 cites W2075763304 @default.
• W2170646712 cites W2077675220 @default.
• W2170646712 cites W2082348062 @default.
• W2170646712 cites W2086082646 @default.
• W2170646712 cites W2086402582 @default.
• W2170646712 cites W2091698048 @default.
• W2170646712 cites W2099260524 @default.
• W2170646712 cites W2101269716 @default.
• W2170646712 cites W2104987499 @default.
• W2170646712 cites W2111082589 @default.
• W2170646712 cites W2112452373 @default.
• W2170646712 cites W2113605815 @default.
• W2170646712 cites W2114041992 @default.
• W2170646712 cites W2119200558 @default.
• W2170646712 cites W2120059732 @default.
• W2170646712 cites W2120336033 @default.
• W2170646712 cites W2120852510 @default.
• W2170646712 cites W2131680108 @default.
• W2170646712 cites W2141277427 @default.
• W2170646712 cites W2142700037 @default.
• W2170646712 cites W2143485119 @default.
• W2170646712 cites W2153647382 @default.
• W2170646712 cites W2153795441 @default.
• W2170646712 cites W2156053266 @default.
• W2170646712 cites W2158603123 @default.
• W2170646712 cites W2161038635 @default.
• W2170646712 cites W2161055036 @default.
• W2170646712 cites W2162576384 @default.
• W2170646712 cites W2164418602 @default.
• W2170646712 cites W2164461312 @default.
• W2170646712 cites W2164612869 @default.
• W2170646712 cites W2169082773 @default.
• W2170646712 cites W2171843668 @default.
• W2170646712 doi "https://doi.org/10.1002/mnfr.201400816" @default.
• W2170646712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25944785" @default.
• W2170646712 hasPublicationYear "2015" @default.
• W2170646712 type Work @default.
• W2170646712 sameAs 2170646712 @default.
• W2170646712 citedByCount "60" @default.
• W2170646712 countsByYear W21706467122015 @default.
• W2170646712 countsByYear W21706467122016 @default.
• W2170646712 countsByYear W21706467122017 @default.
• W2170646712 countsByYear W21706467122018 @default.
• W2170646712 countsByYear W21706467122019 @default.
• W2170646712 countsByYear W21706467122020 @default.
• W2170646712 countsByYear W21706467122021 @default.
• W2170646712 countsByYear W21706467122022 @default.
• W2170646712 crossrefType "journal-article" @default.
• W2170646712 hasAuthorship W2170646712A5015449382 @default.
• W2170646712 hasAuthorship W2170646712A5032583036 @default.
• W2170646712 hasAuthorship W2170646712A5039048300 @default.
• W2170646712 hasAuthorship W2170646712A5042806883 @default.
• W2170646712 hasAuthorship W2170646712A5057125332 @default.
• W2170646712 hasAuthorship W2170646712A5057379888 @default.
• W2170646712 hasAuthorship W2170646712A5064923590 @default.
• W2170646712 hasAuthorship W2170646712A5065661629 @default.

• next