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- W2170646875 abstract "Objective: To investigate and compare the effects of tibolone (0.25mg/kg/day po), conjugated equine estrogen (0,1 mg/kg/day po) and raloxifene (1mg/kg/day po) administered for 4 weeks on the development of osteopenia caused by bilateral ovariectomy in 3-month-old female Wistar rats. Design: The experiments were carried out on five groups of animals: I (C)—control sham operated rats, II (OVX)—ovariectomized rats, III (OVX0.25)—ovariectomized rats which were administered tibolone at a dose of 0.25mg/kg, IV (OVX0,1)—ovariectomized rats which were administered conjugated equine estrogen at a dose of 0,1 mg/kg, V (R-1)- ovariectomized rats which were administered raloxifene at a dose of 1 mg/kg. Material and Methods: The following parameters were examined in all the groups: body weight gain, bone mass, length and diameter, mineral and calcium contents in the tibia and femur, endosteal and periosteal transverse growth, endosteal and periosteal osteoid width, transverse cross-section area of the cortical diaphysis and that of the marrow cavity in the tibia, epiphyseal cartilage width, trabeculae width in the epiphysis and metaphysis of the femur. Mechanical properties of the femur were also studied. Results: Bilateral ovariectomy induced osteopenic skeletal changes in mature female rats. Tibolone (0.25 mg/kg/day), raloxifene (1 mg/kg/day), conjugated equine estrogen (0,1 mg/kg) administered to ovariectomized rats for 28 days decreased the development of osteopenic skeletal changes induced by bilateral ovariectomy. Conclusion: Osteopenia in surgical menopause patients is not a low risk and can be prevented. Treatment should be individualized." @default.
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- W2170646875 date "2003-09-01" @default.
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- W2170646875 title "Comparison of the effects of conjugated equine estrogen+medroxy progesterone acetate, tibolone, and raloxifene on the development of osteopenia induced by ovariectomy in rats" @default.
- W2170646875 doi "https://doi.org/10.1016/s0015-0282(03)01590-5" @default.
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