FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2170687030> ?p ?o ?g. }

• W2170687030 endingPage "2337" @default.
• W2170687030 startingPage "2324" @default.
• W2170687030 abstract "The presence of receptors for ATP has not been established in any native preparation of retinal neurons or glia. In the present study, we used conventional electrophysiological and [Ca 2+ ] in fluorescence imaging techniques to investigate the effects of ATP added to Ringer’s solution perfusing the retinal-facing (apical) membrane of freshly isolated monolayers of bovine retinal pigment epithelium (RPE). ATP (or UTP) produced large, biphasic voltage and resistance changes with a K d of ∼5 μ m for ATP and ∼1 μ m for UTP. Electrical and pharmacological evidence indicates that the first and second phases of the response are attributable to an increase in basolateral membrane Cl conductance and a decrease in apical membrane K conductance, respectively. The ATP-induced responses were not affected by adenosine, but were reduced by the P 2 -purinoceptor blocker suramin. ATP also produced a large, transient increase in [Ca 2+ ] in that was blocked by cyclopiazonic acid, an inhibitor of endoplasmic reticulum Ca 2+ -ATPases. The calcium buffer BAPTA attenuated the voltage effects of ATP. We also found that apical DIDS significantly inhibited the ATP-evoked [Ca 2+ ] in and electrical responses, suggesting that DIDS blocked the purinoceptor. Measurements of fluid movement across the RPE using the capacitance probe technique demonstrated a significant increase in fluid absorption by apical UTP. These data indicate the presence of metabotropic P 2Y /P 2U -purinoceptors at the RPE apical membrane and implicate extracellular ATP in vivo as a retinal signaling molecule that could help regulate the hydration and chemical composition of the subretinal space." @default.
• W2170687030 created "2016-06-24" @default.
• W2170687030 creator A5022140289 @default.
• W2170687030 creator A5028396164 @default.
• W2170687030 creator A5063304021 @default.
• W2170687030 creator A5073177936 @default.
• W2170687030 date "1997-04-01" @default.
• W2170687030 modified "2023-10-11" @default.
• W2170687030 title "Extracellular ATP Activates Calcium Signaling, Ion, and Fluid Transport in Retinal Pigment Epithelium" @default.
• W2170687030 cites W114316392 @default.
• W2170687030 cites W1536253714 @default.
• W2170687030 cites W1547324580 @default.
• W2170687030 cites W1571332834 @default.
• W2170687030 cites W1581555608 @default.
• W2170687030 cites W1633947369 @default.
• W2170687030 cites W1837514060 @default.
• W2170687030 cites W192145889 @default.
• W2170687030 cites W1934587256 @default.
• W2170687030 cites W1974251963 @default.
• W2170687030 cites W197891902 @default.
• W2170687030 cites W1979361590 @default.
• W2170687030 cites W1979541051 @default.
• W2170687030 cites W1984625729 @default.
• W2170687030 cites W1986715239 @default.
• W2170687030 cites W1995134828 @default.
• W2170687030 cites W1996550094 @default.
• W2170687030 cites W1997990428 @default.
• W2170687030 cites W2005285859 @default.
• W2170687030 cites W2006703222 @default.
• W2170687030 cites W2011264359 @default.
• W2170687030 cites W2014916614 @default.
• W2170687030 cites W2027342157 @default.
• W2170687030 cites W2054615749 @default.
• W2170687030 cites W2068242557 @default.
• W2170687030 cites W2074736272 @default.
• W2170687030 cites W2075771764 @default.
• W2170687030 cites W2080297939 @default.
• W2170687030 cites W2084531756 @default.
• W2170687030 cites W2086527059 @default.
• W2170687030 cites W2095312523 @default.
• W2170687030 cites W2115773129 @default.
• W2170687030 cites W2129399005 @default.
• W2170687030 cites W2134676790 @default.
• W2170687030 cites W2148072223 @default.
• W2170687030 cites W2167724640 @default.
• W2170687030 cites W2168341893 @default.
• W2170687030 cites W2253914059 @default.
• W2170687030 cites W2275151554 @default.
• W2170687030 cites W2309473416 @default.
• W2170687030 cites W2404185951 @default.
• W2170687030 cites W2409047845 @default.
• W2170687030 cites W2409404720 @default.
• W2170687030 cites W2416368344 @default.
• W2170687030 cites W2463248084 @default.
• W2170687030 cites W2472027441 @default.
• W2170687030 cites W4255688640 @default.
• W2170687030 cites W63235074 @default.
• W2170687030 doi "https://doi.org/10.1523/jneurosci.17-07-02324.1997" @default.
• W2170687030 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6573488" @default.
• W2170687030 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9065493" @default.
• W2170687030 hasPublicationYear "1997" @default.
• W2170687030 type Work @default.
• W2170687030 sameAs 2170687030 @default.
• W2170687030 citedByCount "122" @default.
• W2170687030 countsByYear W21706870302012 @default.
• W2170687030 countsByYear W21706870302013 @default.
• W2170687030 countsByYear W21706870302014 @default.
• W2170687030 countsByYear W21706870302015 @default.
• W2170687030 countsByYear W21706870302016 @default.
• W2170687030 countsByYear W21706870302017 @default.
• W2170687030 countsByYear W21706870302018 @default.
• W2170687030 countsByYear W21706870302019 @default.
• W2170687030 countsByYear W21706870302020 @default.
• W2170687030 countsByYear W21706870302021 @default.
• W2170687030 countsByYear W21706870302022 @default.
• W2170687030 countsByYear W21706870302023 @default.
• W2170687030 crossrefType "journal-article" @default.
• W2170687030 hasAuthorship W2170687030A5022140289 @default.
• W2170687030 hasAuthorship W2170687030A5028396164 @default.
• W2170687030 hasAuthorship W2170687030A5063304021 @default.
• W2170687030 hasAuthorship W2170687030A5073177936 @default.
• W2170687030 hasBestOaLocation W21706870301 @default.
• W2170687030 hasConcept C12554922 @default.
• W2170687030 hasConcept C158617107 @default.
• W2170687030 hasConcept C170493617 @default.
• W2170687030 hasConcept C185592680 @default.
• W2170687030 hasConcept C2776182878 @default.
• W2170687030 hasConcept C2778024200 @default.
• W2170687030 hasConcept C2779533339 @default.
• W2170687030 hasConcept C2779996123 @default.
• W2170687030 hasConcept C2780827179 @default.
• W2170687030 hasConcept C28406088 @default.
• W2170687030 hasConcept C3018436504 @default.
• W2170687030 hasConcept C41625074 @default.
• W2170687030 hasConcept C55493867 @default.
• W2170687030 hasConcept C57306754 @default.
• W2170687030 hasConcept C86803240 @default.
• W2170687030 hasConcept C95444343 @default.

• next