FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2170691881> ?p ?o ?g. }

• W2170691881 endingPage "1159" @default.
• W2170691881 startingPage "1154" @default.
• W2170691881 abstract "Antigen stimulation of mast cells via FcepsilonRI, the high-affinity receptor for IgE, triggers a signaling cascade that requires Ca(2+) mobilization for exocytosis of secretory granules during an allergic response. This study investigates critical signaling components by using mutant RBL mast cells that are defective in antigen-stimulated phospholipase Cgamma (PLCgamma) activation, as well as other signaling activities downstream of stimulated tyrosine phosphorylation. We show that the expression of activated versions of the Cdc42 or Rac1 GTPase restores antigen-stimulated Ca(2+) mobilization necessary for degranulation in these mutant cells. Wild-type Cdc42 and Rac1, as well as activated Cdc42 containing effector domain mutations, all fail to restore antigen-stimulated signaling leading to exocytosis. Expression of oncogenic Dbl, a guanine nucleotide exchange factor for Cdc42 and Rac1, partially restores sustained Ca(2+) mobilization and degranulation, suggesting that activation of endogenous Cdc42 and/or Rac1 is impaired in the mutant cells. Overexpression of PLCgamma1 with either activated Cdc42 or Rac1 synergistically stimulates degranulation, consistent with a critical defect in PLCgamma activation in these cells. Thus, our results point to activation of Cdc42 and/or Rac1 playing an essential role in antigen stimulation of early events that culminate in mast cell degranulation." @default.
• W2170691881 created "2016-06-24" @default.
• W2170691881 creator A5002939449 @default.
• W2170691881 creator A5023810299 @default.
• W2170691881 creator A5048526342 @default.
• W2170691881 creator A5074163203 @default.
• W2170691881 creator A5079119381 @default.
• W2170691881 date "2001-01-30" @default.
• W2170691881 modified "2023-10-06" @default.
• W2170691881 title "Activated Cdc42/Rac reconstitutes FcɛRI-mediated Ca²⁺mobilization and degranulation in mutant RBL mast cells" @default.
• W2170691881 cites W1503937143 @default.
• W2170691881 cites W1605923846 @default.
• W2170691881 cites W1969563780 @default.
• W2170691881 cites W1980166477 @default.
• W2170691881 cites W1981628302 @default.
• W2170691881 cites W1994139415 @default.
• W2170691881 cites W1997939013 @default.
• W2170691881 cites W2002410732 @default.
• W2170691881 cites W2011751979 @default.
• W2170691881 cites W2015480034 @default.
• W2170691881 cites W2029531386 @default.
• W2170691881 cites W2041772576 @default.
• W2170691881 cites W2056085135 @default.
• W2170691881 cites W2063912602 @default.
• W2170691881 cites W2087992398 @default.
• W2170691881 cites W2096791952 @default.
• W2170691881 cites W2097279016 @default.
• W2170691881 cites W2099036383 @default.
• W2170691881 cites W2117111749 @default.
• W2170691881 cites W2119075209 @default.
• W2170691881 cites W2119256134 @default.
• W2170691881 cites W2132212780 @default.
• W2170691881 cites W2132342067 @default.
• W2170691881 cites W2146415565 @default.
• W2170691881 cites W2169132737 @default.
• W2170691881 cites W54107245 @default.
• W2170691881 doi "https://doi.org/10.1073/pnas.98.3.1154" @default.
• W2170691881 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/14724" @default.
• W2170691881 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11158610" @default.
• W2170691881 hasPublicationYear "2001" @default.
• W2170691881 type Work @default.
• W2170691881 sameAs 2170691881 @default.
• W2170691881 citedByCount "52" @default.
• W2170691881 countsByYear W21706918812012 @default.
• W2170691881 countsByYear W21706918812013 @default.
• W2170691881 countsByYear W21706918812014 @default.
• W2170691881 countsByYear W21706918812016 @default.
• W2170691881 countsByYear W21706918812018 @default.
• W2170691881 countsByYear W21706918812019 @default.
• W2170691881 countsByYear W21706918812021 @default.
• W2170691881 countsByYear W21706918812022 @default.
• W2170691881 countsByYear W21706918812023 @default.
• W2170691881 crossrefType "journal-article" @default.
• W2170691881 hasAuthorship W2170691881A5002939449 @default.
• W2170691881 hasAuthorship W2170691881A5023810299 @default.
• W2170691881 hasAuthorship W2170691881A5048526342 @default.
• W2170691881 hasAuthorship W2170691881A5074163203 @default.
• W2170691881 hasAuthorship W2170691881A5079119381 @default.
• W2170691881 hasBestOaLocation W21706918811 @default.
• W2170691881 hasConcept C11960822 @default.
• W2170691881 hasConcept C126619667 @default.
• W2170691881 hasConcept C170493617 @default.
• W2170691881 hasConcept C175969161 @default.
• W2170691881 hasConcept C185592680 @default.
• W2170691881 hasConcept C203014093 @default.
• W2170691881 hasConcept C207332259 @default.
• W2170691881 hasConcept C2779717556 @default.
• W2170691881 hasConcept C2779726688 @default.
• W2170691881 hasConcept C2780040266 @default.
• W2170691881 hasConcept C49039625 @default.
• W2170691881 hasConcept C49802076 @default.
• W2170691881 hasConcept C55493867 @default.
• W2170691881 hasConcept C62478195 @default.
• W2170691881 hasConcept C86803240 @default.
• W2170691881 hasConcept C95444343 @default.
• W2170691881 hasConceptScore W2170691881C11960822 @default.
• W2170691881 hasConceptScore W2170691881C126619667 @default.
• W2170691881 hasConceptScore W2170691881C170493617 @default.
• W2170691881 hasConceptScore W2170691881C175969161 @default.
• W2170691881 hasConceptScore W2170691881C185592680 @default.
• W2170691881 hasConceptScore W2170691881C203014093 @default.
• W2170691881 hasConceptScore W2170691881C207332259 @default.
• W2170691881 hasConceptScore W2170691881C2779717556 @default.
• W2170691881 hasConceptScore W2170691881C2779726688 @default.
• W2170691881 hasConceptScore W2170691881C2780040266 @default.
• W2170691881 hasConceptScore W2170691881C49039625 @default.
• W2170691881 hasConceptScore W2170691881C49802076 @default.
• W2170691881 hasConceptScore W2170691881C55493867 @default.
• W2170691881 hasConceptScore W2170691881C62478195 @default.
• W2170691881 hasConceptScore W2170691881C86803240 @default.
• W2170691881 hasConceptScore W2170691881C95444343 @default.
• W2170691881 hasIssue "3" @default.
• W2170691881 hasLocation W21706918811 @default.
• W2170691881 hasLocation W21706918812 @default.
• W2170691881 hasLocation W21706918813 @default.
• W2170691881 hasLocation W21706918814 @default.
• W2170691881 hasOpenAccess W2170691881 @default.
• W2170691881 hasPrimaryLocation W21706918811 @default.

• next