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- W2170692256 abstract "The Notch signaling pathway is known to govern various aspects of tissue differentiation during embryonic development by mediating local cell-cell interactions that often control cell fate. The conserved components that underlie Notch signaling have been isolated in vertebrates, leading to a biochemical delineation of a core Notch signaling pathway and functional studies of this pathway during embryogenesis. Herein we highlight recent progress in determining how Notch signaling contributes to the development of the vertebrate embryo. We first discuss the role of Notch in the process of segmentation where rapid changes have been shown to occur in both the spatial and temporal aspects of Notch signaling, which are critical for segmental patterning. Indeed, the role of Notch in segmentation re-emphasizes a recurring question in Notch biology: how are the components involved in Notch signaling regulated to ensure their dynamic properties? Second, we address this question by discussing recent work on the biochemical mechanisms that potentially regulate Notch signaling during segmentation, including those that act on the receptors, ligands, and signal transduction apparatus." @default.
- W2170692256 created "2016-06-24" @default.
- W2170692256 creator A5046210280 @default.
- W2170692256 creator A5080777821 @default.
- W2170692256 date "2003-11-01" @default.
- W2170692256 modified "2023-10-16" @default.
- W2170692256 title "Modulation of Notch Signaling During Somitogenesis" @default.
- W2170692256 cites W1497941038 @default.
- W2170692256 cites W1498740969 @default.
- W2170692256 cites W1508234976 @default.
- W2170692256 cites W1561855402 @default.
- W2170692256 cites W1634376377 @default.
- W2170692256 cites W1871313898 @default.
- W2170692256 cites W1873165927 @default.
- W2170692256 cites W1911156364 @default.
- W2170692256 cites W1948230326 @default.
- W2170692256 cites W1964633462 @default.
- W2170692256 cites W1966496662 @default.
- W2170692256 cites W1967115518 @default.
- W2170692256 cites W1968146121 @default.
- W2170692256 cites W1969862105 @default.
- W2170692256 cites W1973160382 @default.
- W2170692256 cites W1975561755 @default.
- W2170692256 cites W1975826991 @default.
- W2170692256 cites W1976986343 @default.
- W2170692256 cites W1977253322 @default.
- W2170692256 cites W1978556012 @default.
- W2170692256 cites W1980422321 @default.
- W2170692256 cites W1981454724 @default.
- W2170692256 cites W1985553569 @default.
- W2170692256 cites W1989556421 @default.
- W2170692256 cites W1990803574 @default.
- W2170692256 cites W1990891647 @default.
- W2170692256 cites W1995615216 @default.
- W2170692256 cites W2003702370 @default.
- W2170692256 cites W2004325660 @default.
- W2170692256 cites W2004465970 @default.
- W2170692256 cites W2013487530 @default.
- W2170692256 cites W2013505425 @default.
- W2170692256 cites W2016633058 @default.
- W2170692256 cites W2017269341 @default.
- W2170692256 cites W2019007505 @default.
- W2170692256 cites W2021766626 @default.
- W2170692256 cites W2023188066 @default.
- W2170692256 cites W2023205404 @default.
- W2170692256 cites W2023244532 @default.
- W2170692256 cites W2026211608 @default.
- W2170692256 cites W2027128159 @default.
- W2170692256 cites W2032853053 @default.
- W2170692256 cites W2033801528 @default.
- W2170692256 cites W2035732431 @default.
- W2170692256 cites W2036311400 @default.
- W2170692256 cites W2037839892 @default.
- W2170692256 cites W2039092330 @default.
- W2170692256 cites W2041136510 @default.
- W2170692256 cites W2041396837 @default.
- W2170692256 cites W2045790644 @default.
- W2170692256 cites W2049809163 @default.
- W2170692256 cites W2050956563 @default.
- W2170692256 cites W2051944835 @default.
- W2170692256 cites W2056790196 @default.
- W2170692256 cites W2058169506 @default.
- W2170692256 cites W2058733797 @default.
- W2170692256 cites W2058902552 @default.
- W2170692256 cites W2060549526 @default.
- W2170692256 cites W2060635017 @default.
- W2170692256 cites W2062084323 @default.
- W2170692256 cites W2062831228 @default.
- W2170692256 cites W2064574277 @default.
- W2170692256 cites W2065510014 @default.
- W2170692256 cites W2065573660 @default.
- W2170692256 cites W2068425472 @default.
- W2170692256 cites W2069624136 @default.
- W2170692256 cites W2070268999 @default.
- W2170692256 cites W2070934419 @default.
- W2170692256 cites W2071833952 @default.
- W2170692256 cites W2073969798 @default.
- W2170692256 cites W2076724997 @default.
- W2170692256 cites W2081389905 @default.
- W2170692256 cites W2082533656 @default.
- W2170692256 cites W2083280774 @default.
- W2170692256 cites W2084802459 @default.
- W2170692256 cites W2085066991 @default.
- W2170692256 cites W2089492454 @default.
- W2170692256 cites W2094686345 @default.
- W2170692256 cites W2095666604 @default.
- W2170692256 cites W2095969687 @default.
- W2170692256 cites W2096469227 @default.
- W2170692256 cites W2097706279 @default.
- W2170692256 cites W2098503611 @default.
- W2170692256 cites W2099105062 @default.
- W2170692256 cites W2099878990 @default.
- W2170692256 cites W2100699398 @default.
- W2170692256 cites W2100979600 @default.
- W2170692256 cites W2102645961 @default.
- W2170692256 cites W2104593525 @default.
- W2170692256 cites W2109380828 @default.
- W2170692256 cites W2111997519 @default.