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• W2170703764 abstract "<h3>Context</h3>The clinical and etiologic relation between autism spectrum disorders (ASDs) and schizophrenia is unclear. The degree to which these disorders share a basis in etiology has important implications for clinicians, researchers, and those affected by the disorders.<h3>Objective</h3>To determine whether a family history of schizophrenia and/or bipolar disorder is a risk factor for ASD.<h3>Design, Setting, and Participants</h3>We conducted a case-control evaluation of histories of schizophrenia or bipolar disorder in first-degree relatives of probands in 3 samples—population registers in Sweden, Stockholm County (in Sweden), and Israel. Probands met criteria for ASD, and affection status of parents and siblings for schizophrenia and bipolar disorder were established.<h3>Results</h3>The presence of schizophrenia in parents was associated with an increased risk for ASD in a Swedish national cohort (odds ratio [OR], 2.9; 95% CI, 2.5-3.4) and a Stockholm County cohort (OR, 2.9; 95% CI, 2.0-4.1). Similarly, schizophrenia in a sibling was associated with an increased risk for ASD in a Swedish national cohort (OR, 2.6; 95% CI, 2.0-3.2) and an Israeli conscription cohort (OR, 12.1; 95% CI, 4.5-32.0). Bipolar disorder showed a similar pattern of associations but of lesser magnitude.<h3>Conclusions</h3>Findings from these 3 registers along with consistent findings from a similar study in Denmark suggest that ASD, schizophrenia, and bipolar disorder share common etiologic factors." @default.
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• W2170703764 date "2012-11-01" @default.
• W2170703764 modified "2023-09-26" @default.
• W2170703764 title "Family History of Schizophrenia and Bipolar Disorder as Risk Factors for Autism" @default.
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• W2170703764 doi "https://doi.org/10.1001/archgenpsychiatry.2012.730" @default.
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