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• W2170704795 abstract "The biophysics of nucleic acid hybridization and strand displacement have been used for the rational design of a number of nanoscale structures and functions. Recently, molecular amplification methods have been developed in the form of non-covalent DNA catalytic reactions, in which single-stranded DNA (ssDNA) molecules catalyze the release of ssDNA product molecules from multi-stranded complexes. Here, we characterize the robustness and specificity of one such strand displacement-based catalytic reaction. We show that the designed reaction is simultaneously sensitive to sequence mutations in the catalyst and robust to a variety of impurities and molecular noise. These properties facilitate the incorporation of strand displacement-based DNA components in synthetic chemical and biological reaction networks." @default.
• W2170704795 created "2016-06-24" @default.
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• W2170704795 date "2010-03-01" @default.
• W2170704795 modified "2023-10-01" @default.
• W2170704795 title "Robustness and modularity properties of a non-covalent DNA catalytic reaction" @default.
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• W2170704795 doi "https://doi.org/10.1093/nar/gkq088" @default.
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