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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2170705512> ?p ?o ?g. }

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• W2170705512 abstract "ABSTRACT The M141 protein of myxoma virus (MYXV) is a viral CD200 homolog (also called vOX-2) that inhibits macrophage activation in infected rabbits. Here, we show that murine myeloid RAW 264.7 cells became activated when infected with MYXV in which the M141 gene was deleted (vMyx-M141KO) but not with the parental wild-type MYXV. Moreover, transcript and protein levels of tumor necrosis factor and granulocyte colony-stimulating factor were rapidly upregulated in an NF-κB-dependent fashion in the RAW 264.7 cells infected with vMyx-M141KO. M141 protein is present in the virion and counteracts this NF-κB activation pathway upon infection with the wild-type MYXV. Our data suggest that upregulation of these classic macrophage-related proinflammatory cytokine markers following infection of myeloid cells with the M141-knockout MYXV is mediated via the rapid activation of the cellular NF-κB pathway." @default.
• W2170705512 created "2016-06-24" @default.
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• W2170705512 date "2009-09-15" @default.
• W2170705512 modified "2023-09-27" @default.
• W2170705512 title "Inhibition of Macrophage Activation by the Myxoma Virus M141 Protein (vCD200)" @default.
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• W2170705512 doi "https://doi.org/10.1128/jvi.01078-09" @default.
• W2170705512 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2738222" @default.
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