Matches in SemOpenAlex for { <https://semopenalex.org/work/W2170705777> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2170705777 endingPage "5352" @default.
- W2170705777 startingPage "5346" @default.
- W2170705777 abstract "ABSTRACT Envelope proteins of hepadnaviruses undergo a unique folding mechanism which results in the posttranslational translocation of 50% of the large envelope protein (L) chains across the endoplasmic reticulum. This mechanism is essential for the eventual positioning of the receptor-binding domain on the surface of the virus particle and in duck hepatitis B virus (DHBV) is dependent on the small (S) envelope protein as part of the assembly process. In this study, we report the identification of a third envelope protein, S t , derived from the S protein and carrying functions previously attributed to S. Antibody mapping and mutagenesis studies indicated S t to be C terminally truncated, spanning the N-terminal transmembrane domain (TM1) plus the adjacent cysteine loop. We have previously shown that the mutation of two conserved polar residues in TM1 of S (S AA ) eliminates L translocation and assembly. A plasmid expressing a functional equivalent of S t was able to rescue assembly, demonstrating that this assembly defect is due to mutations of the corresponding residues in S t and not in S per se. Immunofluorescence analysis showed that S t directly affects L protein cellular localization. These results indicate that S t acts as a viral chaperone for L folding, remaining associated with the DHBV envelope upon secretion. The presence of S t at a molar ratio of half that of L suggests that it is S t which regulates L translocation to 50%." @default.
- W2170705777 created "2016-06-24" @default.
- W2170705777 creator A5079010924 @default.
- W2170705777 creator A5080422098 @default.
- W2170705777 date "2005-05-01" @default.
- W2170705777 modified "2023-09-26" @default.
- W2170705777 title "S t , a Truncated Envelope Protein Derived from the S Protein of Duck Hepatitis B Virus, Acts as a Chaperone for the Folding of the Large Envelope Protein" @default.
- W2170705777 cites W1269890246 @default.
- W2170705777 cites W1493281034 @default.
- W2170705777 cites W1532585732 @default.
- W2170705777 cites W1557805105 @default.
- W2170705777 cites W1572160129 @default.
- W2170705777 cites W1626609611 @default.
- W2170705777 cites W1715270133 @default.
- W2170705777 cites W1751218746 @default.
- W2170705777 cites W1879322514 @default.
- W2170705777 cites W1972027345 @default.
- W2170705777 cites W1972480731 @default.
- W2170705777 cites W2001990736 @default.
- W2170705777 cites W2047513678 @default.
- W2170705777 cites W2090365757 @default.
- W2170705777 cites W2090955803 @default.
- W2170705777 cites W2106874316 @default.
- W2170705777 cites W2107202933 @default.
- W2170705777 cites W2116896819 @default.
- W2170705777 cites W2120077862 @default.
- W2170705777 cites W2129868732 @default.
- W2170705777 cites W2134653235 @default.
- W2170705777 cites W2150001528 @default.
- W2170705777 cites W2157191506 @default.
- W2170705777 cites W2171091522 @default.
- W2170705777 cites W57144322 @default.
- W2170705777 doi "https://doi.org/10.1128/jvi.79.9.5346-5352.2005" @default.
- W2170705777 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1082741" @default.
- W2170705777 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15827149" @default.
- W2170705777 hasPublicationYear "2005" @default.
- W2170705777 type Work @default.
- W2170705777 sameAs 2170705777 @default.
- W2170705777 citedByCount "12" @default.
- W2170705777 countsByYear W21707057772012 @default.
- W2170705777 countsByYear W21707057772018 @default.
- W2170705777 countsByYear W21707057772019 @default.
- W2170705777 countsByYear W21707057772020 @default.
- W2170705777 crossrefType "journal-article" @default.
- W2170705777 hasAuthorship W2170705777A5079010924 @default.
- W2170705777 hasAuthorship W2170705777A5080422098 @default.
- W2170705777 hasBestOaLocation W21707057772 @default.
- W2170705777 hasConcept C142724271 @default.
- W2170705777 hasConcept C153911025 @default.
- W2170705777 hasConcept C158617107 @default.
- W2170705777 hasConcept C159047783 @default.
- W2170705777 hasConcept C204328495 @default.
- W2170705777 hasConcept C2522874641 @default.
- W2170705777 hasConcept C2775962898 @default.
- W2170705777 hasConcept C2777666129 @default.
- W2170705777 hasConcept C2780593183 @default.
- W2170705777 hasConcept C2780617729 @default.
- W2170705777 hasConcept C71924100 @default.
- W2170705777 hasConcept C86803240 @default.
- W2170705777 hasConcept C95444343 @default.
- W2170705777 hasConceptScore W2170705777C142724271 @default.
- W2170705777 hasConceptScore W2170705777C153911025 @default.
- W2170705777 hasConceptScore W2170705777C158617107 @default.
- W2170705777 hasConceptScore W2170705777C159047783 @default.
- W2170705777 hasConceptScore W2170705777C204328495 @default.
- W2170705777 hasConceptScore W2170705777C2522874641 @default.
- W2170705777 hasConceptScore W2170705777C2775962898 @default.
- W2170705777 hasConceptScore W2170705777C2777666129 @default.
- W2170705777 hasConceptScore W2170705777C2780593183 @default.
- W2170705777 hasConceptScore W2170705777C2780617729 @default.
- W2170705777 hasConceptScore W2170705777C71924100 @default.
- W2170705777 hasConceptScore W2170705777C86803240 @default.
- W2170705777 hasConceptScore W2170705777C95444343 @default.
- W2170705777 hasIssue "9" @default.
- W2170705777 hasLocation W21707057771 @default.
- W2170705777 hasLocation W21707057772 @default.
- W2170705777 hasLocation W21707057773 @default.
- W2170705777 hasLocation W21707057774 @default.
- W2170705777 hasOpenAccess W2170705777 @default.
- W2170705777 hasPrimaryLocation W21707057771 @default.
- W2170705777 hasRelatedWork W2052271334 @default.
- W2170705777 hasRelatedWork W2087516011 @default.
- W2170705777 hasRelatedWork W2099429272 @default.
- W2170705777 hasRelatedWork W2161604602 @default.
- W2170705777 hasRelatedWork W2618230221 @default.
- W2170705777 hasRelatedWork W2622529157 @default.
- W2170705777 hasRelatedWork W3165347333 @default.
- W2170705777 hasRelatedWork W3210245663 @default.
- W2170705777 hasRelatedWork W4311514635 @default.
- W2170705777 hasRelatedWork W2746164967 @default.
- W2170705777 hasVolume "79" @default.
- W2170705777 isParatext "false" @default.
- W2170705777 isRetracted "false" @default.
- W2170705777 magId "2170705777" @default.
- W2170705777 workType "article" @default.