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- W2170706610 endingPage "219" @default.
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- W2170706610 abstract "There has been a resurgence of interest for the field of cardiac metabolism catalysed by the increased need for new therapeutic targets for patients with heart failure. The primary focus of research in this area to date has been on the impact of substrate selection for oxidative energy metabolism; however, anaplerotic metabolism also has significant interest for its potential cardioprotective role. Anaplerosis refers to metabolic pathways that replenish the citric acid cycle intermediates, which are essential to energy metabolism; however, our understanding of the role and regulation of this process in the heart, particularly under pathophysiological conditions, is very limited. Therefore, the goal of this article is to provide a foundation for future directions of research on cardiac anaplerosis and heart disease. We include an overview of anaplerotic metabolism, a critical evaluation of current methods available for its quantitation in the intact heart, and a discussion of its role and regulation both in health and disease as it is currently understood based mostly on animal studies. We also consider genetic diseases affecting anaplerotic pathways in humans and acute intervention studies with anaplerotic substrates in the clinics. Finally, as future perspectives, we will share our thoughts about potential benefits and practical considerations on modalities of interventions targeting anaplerosis in heart disease, including heart failure." @default.
- W2170706610 created "2016-06-24" @default.
- W2170706610 creator A5016096111 @default.
- W2170706610 creator A5020011946 @default.
- W2170706610 creator A5040168425 @default.
- W2170706610 creator A5090854806 @default.
- W2170706610 date "2011-03-11" @default.
- W2170706610 modified "2023-10-10" @default.
- W2170706610 title "Cardiac anaplerosis in health and disease: food for thought" @default.
- W2170706610 cites W1063595 @default.
- W2170706610 cites W1497416107 @default.
- W2170706610 cites W150567169 @default.
- W2170706610 cites W1547384695 @default.
- W2170706610 cites W1673039816 @default.
- W2170706610 cites W1831293047 @default.
- W2170706610 cites W1858301031 @default.
- W2170706610 cites W1963966252 @default.
- W2170706610 cites W1964616054 @default.
- W2170706610 cites W1965649200 @default.
- W2170706610 cites W1967763397 @default.
- W2170706610 cites W1972439979 @default.
- W2170706610 cites W1972913443 @default.
- W2170706610 cites W1976568495 @default.
- W2170706610 cites W1981171493 @default.
- W2170706610 cites W1982283232 @default.
- W2170706610 cites W1982623029 @default.
- W2170706610 cites W1985259535 @default.
- W2170706610 cites W1986041038 @default.
- W2170706610 cites W1986754589 @default.
- W2170706610 cites W1991327433 @default.
- W2170706610 cites W1993102424 @default.
- W2170706610 cites W1998426806 @default.
- W2170706610 cites W1999407527 @default.
- W2170706610 cites W2000319510 @default.
- W2170706610 cites W2004183689 @default.
- W2170706610 cites W2004794745 @default.
- W2170706610 cites W2007174173 @default.
- W2170706610 cites W2007425036 @default.
- W2170706610 cites W2008824028 @default.
- W2170706610 cites W2012378401 @default.
- W2170706610 cites W2012585272 @default.
- W2170706610 cites W2015046254 @default.
- W2170706610 cites W2021129026 @default.
- W2170706610 cites W2022228039 @default.
- W2170706610 cites W2022570317 @default.
- W2170706610 cites W2024466873 @default.
- W2170706610 cites W2031518757 @default.
- W2170706610 cites W2033336897 @default.
- W2170706610 cites W2033513523 @default.
- W2170706610 cites W2036753725 @default.
- W2170706610 cites W2043053568 @default.
- W2170706610 cites W2043541600 @default.
- W2170706610 cites W2044049499 @default.
- W2170706610 cites W2047040592 @default.
- W2170706610 cites W2052751736 @default.
- W2170706610 cites W2054336283 @default.
- W2170706610 cites W2055255976 @default.
- W2170706610 cites W2060000025 @default.
- W2170706610 cites W2060762124 @default.
- W2170706610 cites W2068337616 @default.
- W2170706610 cites W2070647639 @default.
- W2170706610 cites W2073531717 @default.
- W2170706610 cites W2074542314 @default.
- W2170706610 cites W2079151410 @default.
- W2170706610 cites W2080335232 @default.
- W2170706610 cites W2081038392 @default.
- W2170706610 cites W2085901707 @default.
- W2170706610 cites W2087472726 @default.
- W2170706610 cites W2090406819 @default.
- W2170706610 cites W2092529874 @default.
- W2170706610 cites W2093025148 @default.
- W2170706610 cites W2094441974 @default.
- W2170706610 cites W2096286415 @default.
- W2170706610 cites W2097259163 @default.
- W2170706610 cites W2098978387 @default.
- W2170706610 cites W2104060734 @default.
- W2170706610 cites W2104740972 @default.
- W2170706610 cites W2108648814 @default.
- W2170706610 cites W2120307618 @default.
- W2170706610 cites W2122367003 @default.
- W2170706610 cites W2122954934 @default.
- W2170706610 cites W2127387895 @default.
- W2170706610 cites W2128606426 @default.
- W2170706610 cites W2134294998 @default.
- W2170706610 cites W2134673828 @default.
- W2170706610 cites W2136799853 @default.
- W2170706610 cites W2141534507 @default.
- W2170706610 cites W2143121088 @default.
- W2170706610 cites W2151406110 @default.
- W2170706610 cites W2151482751 @default.
- W2170706610 cites W2152822042 @default.
- W2170706610 cites W2153819921 @default.
- W2170706610 cites W2156137058 @default.
- W2170706610 cites W2158408543 @default.
- W2170706610 cites W2161321266 @default.
- W2170706610 cites W2163327996 @default.
- W2170706610 cites W2163381801 @default.
- W2170706610 cites W2165274786 @default.