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- W2170707979 abstract "Heterosexual transmission of human immunodeficiency virus-1 (HIV-1), from men to women, involves exposure to infectious HIV-1 in semen. Therefore, the cellular and molecular processes that underlie HIV-1 transmission are closely interconnected with fundamental principles of human reproductive biology. Human ex vivo organ culture systems allow experimental reconstruction of HIV-1 transmission, using human semen and premenopausal cervicovaginal mucosal tissue, with specific emphasis on the progression from exposure to development of primary HIV-1 infection. Clearly, an isolated piece of human tissue cannot duplicate the full complexity of events in natural infections, but with correct observation of conventional medical and ethical standards, there is no opportunity to study HIV-1 exposure and primary infection in young women. Human mucosal organ cultures allow direct study of HIV-1 infection in a reproducible format while retaining major elements of complexity and variability that typify community-based HIV-1 transmission. Experimental manipulation of human mucosal tissue both allows and requires acquisition of new insights into basic processes of human mucosal immunology. Expanding from the current foundations, we believe that human organ cultures will become increasingly prominent in experimental studies of HIV-1 transmission and continuing efforts to prevent HIV-1 infection at human mucosal surfaces." @default.
- W2170707979 created "2016-06-24" @default.
- W2170707979 creator A5012816522 @default.
- W2170707979 creator A5029872054 @default.
- W2170707979 creator A5044037509 @default.
- W2170707979 creator A5076112425 @default.
- W2170707979 date "2011-07-01" @default.
- W2170707979 modified "2023-09-29" @default.
- W2170707979 title "Coming of age: reconstruction of heterosexual HIV-1 transmission in human ex vivo organ culture systems" @default.
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