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• W2170710010 abstract "Objective Systemic lupus erythematosus (SLE) is an autoimmune disease that affects women nine times more often than men. The present study investigates estradiol-dependent control of the calcium-buffering protein, calreticulin, to gain further insight into the molecular basis of abnormal T cell signaling in SLE T cells. Methods T cells were purified from blood samples obtained from healthy females and SLE patients. Calreticulin expression was quantified by real-time polymerase chain amplification. Calreticulin and estrogen receptor-α were co-precipitated and analyzed by Western blotting to determine if the proteins associate in T cells. Results Calreticulin expression increased ( p = 0.034) in activated control T cells, while estradiol decreased ( p = 0.044) calreticulin in resting T cells. Calreticulin expression decreased in activated SLE T cell samples and increased in approximately 50% of resting T cell samples. Plasma estradiol was similar ( p > 0.05) among SLE patients and control volunteers. Estrogen receptor-α and calreticulin co-precipitated from nuclear and cytoplasmic T cell compartments. Conclusions The results indicate that estradiol tightly regulates calreticulin expression in normal human T cells, and the dynamics are different between activated and resting T cells. The absence of this tight regulation in SLE T cells could contribute to abnormal T cell function." @default.
• W2170710010 created "2016-06-24" @default.
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• W2170710010 date "2013-03-27" @default.
• W2170710010 modified "2023-09-23" @default.
• W2170710010 title "Estradiol differentially regulates calreticulin: a potential link with abnormal T cell function in systemic lupus erythematosus?" @default.
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• W2170710010 doi "https://doi.org/10.1177/0961203313482742" @default.
• W2170710010 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4072130" @default.
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