Matches in SemOpenAlex for { <https://semopenalex.org/work/W2170720478> ?p ?o ?g. }
- W2170720478 endingPage "9" @default.
- W2170720478 startingPage "4245" @default.
- W2170720478 abstract "Cyclooxygenase (COX)-2, an inducible enzyme that catalyzes the formation of prostaglandins and other eicosanoids from arachidonic acid, is constitutively expressed in LNCaP human prostate cancer cell line. To evaluate the potential role of COX-2 in prostate cancer, LNCaP cells were treated with NS398, a selective COX-2 inhibitor, and the effects on cell viability and apoptosis were determined. NS398 treatment induced apoptosis in LNCaP cells in a time- and dose-dependent fashion. Treatment with 100 microM NS398 caused a down-regulation in bcl-2 protein expression, followed by chromatin condensation, chromosomal DNA fragmentation, and changes in nuclear morphology detected by 4,6-diamidino-2-phenylindole staining, DNA fragmentation assay, and terminal deoxynucleotidyl transferase-mediated UTP-biotin nick end-labeling assay. In contrast, NS398 treatment had no effect on either cell viability or nuclear function and morphology in human fetal prostate fibroblasts. These results demonstrate that NS398 induces apoptosis in LNCaP cells but not in human fetal prostate fibroblasts, and that this induction is associated with a decreased level of bcl-2 protein." @default.
- W2170720478 created "2016-06-24" @default.
- W2170720478 creator A5014280061 @default.
- W2170720478 creator A5023108032 @default.
- W2170720478 creator A5075926965 @default.
- W2170720478 creator A5085576609 @default.
- W2170720478 date "1998-10-01" @default.
- W2170720478 modified "2023-09-23" @default.
- W2170720478 title "NS398, a selective cyclooxygenase-2 inhibitor, induces apoptosis and down-regulates bcl-2 expression in LNCaP cells." @default.
- W2170720478 cites W1485442945 @default.
- W2170720478 cites W1592603695 @default.
- W2170720478 cites W1648593433 @default.
- W2170720478 cites W1685016018 @default.
- W2170720478 cites W1766737321 @default.
- W2170720478 cites W1979995768 @default.
- W2170720478 cites W1996522179 @default.
- W2170720478 cites W2009132110 @default.
- W2170720478 cites W2031465452 @default.
- W2170720478 cites W2043707891 @default.
- W2170720478 cites W2054363987 @default.
- W2170720478 cites W2070718488 @default.
- W2170720478 cites W2078297328 @default.
- W2170720478 cites W2088263896 @default.
- W2170720478 cites W2107359522 @default.
- W2170720478 cites W2115522061 @default.
- W2170720478 cites W2156470937 @default.
- W2170720478 cites W2163462883 @default.
- W2170720478 cites W26755955 @default.
- W2170720478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9766645" @default.
- W2170720478 hasPublicationYear "1998" @default.
- W2170720478 type Work @default.
- W2170720478 sameAs 2170720478 @default.
- W2170720478 citedByCount "166" @default.
- W2170720478 countsByYear W21707204782012 @default.
- W2170720478 countsByYear W21707204782013 @default.
- W2170720478 countsByYear W21707204782014 @default.
- W2170720478 countsByYear W21707204782015 @default.
- W2170720478 countsByYear W21707204782016 @default.
- W2170720478 countsByYear W21707204782017 @default.
- W2170720478 countsByYear W21707204782018 @default.
- W2170720478 countsByYear W21707204782019 @default.
- W2170720478 countsByYear W21707204782020 @default.
- W2170720478 countsByYear W21707204782021 @default.
- W2170720478 crossrefType "journal-article" @default.
- W2170720478 hasAuthorship W2170720478A5014280061 @default.
- W2170720478 hasAuthorship W2170720478A5023108032 @default.
- W2170720478 hasAuthorship W2170720478A5075926965 @default.
- W2170720478 hasAuthorship W2170720478A5085576609 @default.
- W2170720478 hasConcept C121608353 @default.
- W2170720478 hasConcept C153911025 @default.
- W2170720478 hasConcept C154113507 @default.
- W2170720478 hasConcept C181199279 @default.
- W2170720478 hasConcept C18903297 @default.
- W2170720478 hasConcept C190283241 @default.
- W2170720478 hasConcept C191015642 @default.
- W2170720478 hasConcept C196795494 @default.
- W2170720478 hasConcept C2779689624 @default.
- W2170720478 hasConcept C2779723316 @default.
- W2170720478 hasConcept C2780192828 @default.
- W2170720478 hasConcept C31573885 @default.
- W2170720478 hasConcept C43759708 @default.
- W2170720478 hasConcept C502942594 @default.
- W2170720478 hasConcept C53227056 @default.
- W2170720478 hasConcept C54355233 @default.
- W2170720478 hasConcept C55493867 @default.
- W2170720478 hasConcept C86803240 @default.
- W2170720478 hasConceptScore W2170720478C121608353 @default.
- W2170720478 hasConceptScore W2170720478C153911025 @default.
- W2170720478 hasConceptScore W2170720478C154113507 @default.
- W2170720478 hasConceptScore W2170720478C181199279 @default.
- W2170720478 hasConceptScore W2170720478C18903297 @default.
- W2170720478 hasConceptScore W2170720478C190283241 @default.
- W2170720478 hasConceptScore W2170720478C191015642 @default.
- W2170720478 hasConceptScore W2170720478C196795494 @default.
- W2170720478 hasConceptScore W2170720478C2779689624 @default.
- W2170720478 hasConceptScore W2170720478C2779723316 @default.
- W2170720478 hasConceptScore W2170720478C2780192828 @default.
- W2170720478 hasConceptScore W2170720478C31573885 @default.
- W2170720478 hasConceptScore W2170720478C43759708 @default.
- W2170720478 hasConceptScore W2170720478C502942594 @default.
- W2170720478 hasConceptScore W2170720478C53227056 @default.
- W2170720478 hasConceptScore W2170720478C54355233 @default.
- W2170720478 hasConceptScore W2170720478C55493867 @default.
- W2170720478 hasConceptScore W2170720478C86803240 @default.
- W2170720478 hasIssue "19" @default.
- W2170720478 hasLocation W21707204781 @default.
- W2170720478 hasOpenAccess W2170720478 @default.
- W2170720478 hasPrimaryLocation W21707204781 @default.
- W2170720478 hasRelatedWork W1536213364 @default.
- W2170720478 hasRelatedWork W1978454953 @default.
- W2170720478 hasRelatedWork W2043358826 @default.
- W2170720478 hasRelatedWork W2051146343 @default.
- W2170720478 hasRelatedWork W2087173305 @default.
- W2170720478 hasRelatedWork W2169869929 @default.
- W2170720478 hasRelatedWork W2170720478 @default.
- W2170720478 hasRelatedWork W2464218786 @default.
- W2170720478 hasRelatedWork W3157088118 @default.
- W2170720478 hasRelatedWork W36530132 @default.