Matches in SemOpenAlex for { <https://semopenalex.org/work/W2170736126> ?p ?o ?g. }
- W2170736126 endingPage "2133" @default.
- W2170736126 startingPage "2118" @default.
- W2170736126 abstract "After their assembly in the nucleolus, ribosomal subunits are exported from the nucleus to the cytoplasm. After export, the 20S rRNA in the small ribosomal subunit is cleaved to yield 18S rRNA and the small 5' ITS1 fragment. The 5' ITS1 RNA is normally degraded by the cytoplasmic Xrn1 exonuclease, but in strains lacking XRN1, the 5' ITS1 fragment accumulates in the cytoplasm. Using the cytoplasmic localization of the 5' ITS1 fragment as an indicator for the export of the small ribosomal subunit, we have identified genes that are required for ribosome export. Ribosome export is dependent on the Ran-GTPase as mutations in Ran or its regulators caused 5' ITS1 to accumulate in the nucleoplasm. Mutations in the genes encoding the nucleoporin Nup82 and in the NES exporter Xpo1/Crm1 also caused the nucleoplasmic accumulation of 5' ITS1. Mutants in a subset of nucleoporins and in the nuclear transport factors Srp1, Kap95, Pse1, Cse1, and Mtr10 accumulate the 5' ITS1 in the nucleolus and affect ribosome assembly. In contrast, we did not detect nuclear accumulation of 5' ITS1 in 28 yeast strains that have mutations in other genes affecting nuclear trafficking." @default.
- W2170736126 created "2016-06-24" @default.
- W2170736126 creator A5009599168 @default.
- W2170736126 creator A5087859961 @default.
- W2170736126 date "1999-08-15" @default.
- W2170736126 modified "2023-10-14" @default.
- W2170736126 title "Nuclear export of the small ribosomal subunit requires the Ran-GTPase cycle and certain nucleoporins" @default.
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