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• W2170741258 abstract "Using the forced swimming test in mice, we examined the effect of the following antidepressants: citalopram, imipramine, desipramine and moclobemide (which are characterized by different mechanisms of action), administered in combination with the selective 5-HT7 receptor antagonist (2R)-1-[(3-hydroxyphenyl)sulfonyl]-2-[2-(4-methyl-1-piperidinyl)ethyl]-pyrrolidine (SB 269970). All those drugs were given in doses which did not shorten the immobility time of mice. Citalopram (1.25 mg/kg), imipramine (10 mg/kg), desipramine (5 mg/kg) or moclobemide (10 mg/kg) administered jointly with SB 269970 (5 mg/kg), produced a significant antidepressant-like effect. None of the compounds studied, given alone or in combination, increased the spontaneous locomotor activity of mice. The obtained results indicate that blockade of 5-HT7 receptors may facilitate the anti-immobility effect of antidepressants in mice." @default.
• W2170741258 created "2016-06-24" @default.
• W2170741258 creator A5022670452 @default.
• W2170741258 creator A5022808795 @default.
• W2170741258 creator A5048295093 @default.
• W2170741258 creator A5063136072 @default.
• W2170741258 date "2007-01-01" @default.
• W2170741258 modified "2023-10-16" @default.
• W2170741258 title "Enhancement of the anti-immobility action of antidepressants by a selective 5-HT7 receptor antagonist in the forced swimming test in mice" @default.
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• W2170741258 doi "https://doi.org/10.1016/j.ejphar.2006.10.001" @default.
• W2170741258 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17109856" @default.
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