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- W2170742997 abstract "U3 small nucleolar RNA (snoRNA) and associated proteins are required for the processing of preribosomal RNA (pre-rRNA) and assembly of preribosomes. There are two major U3 snoRNA-containing complexes. The monoparticle contains U3 snoRNA and the core Box C/D snoRNA-associated proteins and an early preribosome-associated complex contains the monoparticle and additional factors that we refer to as preribosome-associated proteins. To address how and where the U3 snoRNA-containing preribosome assembles and how these processes are temporally and spatially regulated, we have examined the dynamics and distribution of human U3 complex-associated components in cells with active or inactive transcription of rDNA. We found that U3 complex-associated proteins shuttle between the nucleus and the cytoplasm independent of the synthesis and export of preribosomal particles, suggesting that the shuttling of these proteins may either provide opportunities for their regulation, or contribute to or modulate ribosome export. In addition, monoparticle and preribosome associated components predominantly localize to different nucleolar substructures, fibrillar components, and granular components, respectively, in active nucleoli, and partition separately into the two components during nucleolar segregation induced by inhibition of pol I transcription. Although the predominant localizations of these two sets of factors differ, there are significant areas of overlap that may represent the sites where they reside as a single complex. These results are consistent with a model in which U3 monoparticles associate with the fibrillar components of nucleoli and bind pre-rRNA during transcription, triggering recruitment of preribosome-associated proteins to assemble the complex necessary for pre-rRNA processing." @default.
- W2170742997 created "2016-06-24" @default.
- W2170742997 creator A5002716376 @default.
- W2170742997 creator A5036458724 @default.
- W2170742997 creator A5052146932 @default.
- W2170742997 date "2004-01-01" @default.
- W2170742997 modified "2023-10-16" @default.
- W2170742997 title "Components of U3 snoRNA-containing Complexes Shuttle between Nuclei and the Cytoplasm and Differentially Localize in Nucleoli: Implications for Assembly and Function" @default.
- W2170742997 cites W109701900 @default.
- W2170742997 cites W11162155 @default.
- W2170742997 cites W143303542 @default.
- W2170742997 cites W1494838952 @default.
- W2170742997 cites W1506119659 @default.
- W2170742997 cites W1549520851 @default.
- W2170742997 cites W1562998360 @default.
- W2170742997 cites W1607339340 @default.
- W2170742997 cites W1635552303 @default.
- W2170742997 cites W1727514194 @default.
- W2170742997 cites W1747266960 @default.
- W2170742997 cites W1775705481 @default.
- W2170742997 cites W1778353316 @default.
- W2170742997 cites W1820010775 @default.
- W2170742997 cites W1823764696 @default.
- W2170742997 cites W1844218649 @default.
- W2170742997 cites W1869934225 @default.
- W2170742997 cites W1925850732 @default.
- W2170742997 cites W1964834936 @default.
- W2170742997 cites W1970720940 @default.
- W2170742997 cites W1974881281 @default.
- W2170742997 cites W1984912806 @default.
- W2170742997 cites W1989221817 @default.
- W2170742997 cites W1992245881 @default.
- W2170742997 cites W1993719557 @default.
- W2170742997 cites W1994566492 @default.
- W2170742997 cites W1998905553 @default.
- W2170742997 cites W2001398820 @default.
- W2170742997 cites W2004827180 @default.
- W2170742997 cites W2005042567 @default.
- W2170742997 cites W2009183437 @default.
- W2170742997 cites W2011844607 @default.
- W2170742997 cites W2013303176 @default.
- W2170742997 cites W2015924376 @default.
- W2170742997 cites W2018702601 @default.
- W2170742997 cites W2021988776 @default.
- W2170742997 cites W2022056903 @default.
- W2170742997 cites W2022523272 @default.
- W2170742997 cites W2023905948 @default.
- W2170742997 cites W2025297048 @default.
- W2170742997 cites W2029300932 @default.
- W2170742997 cites W2030750127 @default.
- W2170742997 cites W2030824756 @default.
- W2170742997 cites W2031922297 @default.
- W2170742997 cites W2037875706 @default.
- W2170742997 cites W2042989445 @default.
- W2170742997 cites W2045696146 @default.
- W2170742997 cites W2046422192 @default.
- W2170742997 cites W2054175147 @default.
- W2170742997 cites W2054544162 @default.
- W2170742997 cites W2057702463 @default.
- W2170742997 cites W2060678979 @default.
- W2170742997 cites W2066922610 @default.
- W2170742997 cites W2067330753 @default.
- W2170742997 cites W2069359878 @default.
- W2170742997 cites W2069725464 @default.
- W2170742997 cites W2074573090 @default.
- W2170742997 cites W2076565543 @default.
- W2170742997 cites W2076819342 @default.
- W2170742997 cites W2080459885 @default.
- W2170742997 cites W2081133503 @default.
- W2170742997 cites W2083340704 @default.
- W2170742997 cites W2084619201 @default.
- W2170742997 cites W2087472232 @default.
- W2170742997 cites W2087672655 @default.
- W2170742997 cites W2094107632 @default.
- W2170742997 cites W2096376758 @default.
- W2170742997 cites W2100400436 @default.
- W2170742997 cites W2108566341 @default.
- W2170742997 cites W2111624324 @default.
- W2170742997 cites W2116360991 @default.
- W2170742997 cites W2117671607 @default.
- W2170742997 cites W2122681042 @default.
- W2170742997 cites W2124939400 @default.
- W2170742997 cites W2126219914 @default.
- W2170742997 cites W2127390075 @default.
- W2170742997 cites W2130657959 @default.
- W2170742997 cites W2132623938 @default.
- W2170742997 cites W2134725862 @default.
- W2170742997 cites W2135273573 @default.
- W2170742997 cites W2136299065 @default.
- W2170742997 cites W2137214237 @default.
- W2170742997 cites W2138165292 @default.
- W2170742997 cites W2138518549 @default.
- W2170742997 cites W2138647063 @default.
- W2170742997 cites W2140748458 @default.
- W2170742997 cites W2141975228 @default.
- W2170742997 cites W2142351060 @default.
- W2170742997 cites W2143680946 @default.
- W2170742997 cites W2144244346 @default.