Matches in SemOpenAlex for { <https://semopenalex.org/work/W2170746223> ?p ?o ?g. }
- W2170746223 endingPage "G957" @default.
- W2170746223 startingPage "G949" @default.
- W2170746223 abstract "The enteric nervous system (ENS), referred to as the “second brain,” comprises a vast number of neurons that form an elegant network throughout the gastrointestinal tract. Neuropeptides produced by the ENS play a crucial role in the regulation of inflammatory processes via cross talk with the enteric immune system. In addition, neuropeptides have paracrine effects on epithelial secretion, thus regulating epithelial barrier functions and thereby susceptibility to inflammation. Ultimately the inflammatory response damages the enteric neurons themselves, resulting in deregulations in circuitry and gut motility. In this review, we have emphasized the concept of neurogenic inflammation and the interaction between the enteric immune system and enteric nervous system, focusing on neuropeptide Y (NPY) and vasoactive intestinal peptide (VIP). The alterations in the expression of NPY and VIP in inflammation and their significant roles in immunomodulation are discussed. We highlight the mechanism of action of these neuropeptides on immune cells, focusing on the key receptors as well as the intracellular signaling pathways that are activated to regulate the release of cytokines. In addition, we also examine the direct and indirect mechanisms of neuropeptide regulation of epithelial tight junctions and permeability, which are a crucial determinant of susceptibility to inflammation. Finally, we also discuss the potential of emerging neuropeptide-based therapies that utilize peptide agonists, antagonists, siRNA, oligonucleotides, and lentiviral vectors." @default.
- W2170746223 created "2016-06-24" @default.
- W2170746223 creator A5037449345 @default.
- W2170746223 creator A5063302307 @default.
- W2170746223 creator A5091361579 @default.
- W2170746223 date "2013-06-01" @default.
- W2170746223 modified "2023-10-01" @default.
- W2170746223 title "Emerging neuropeptide targets in inflammation: NPY and VIP" @default.
- W2170746223 cites W1533386139 @default.
- W2170746223 cites W1553995079 @default.
- W2170746223 cites W1584257009 @default.
- W2170746223 cites W1895486119 @default.
- W2170746223 cites W1966217983 @default.
- W2170746223 cites W1968237507 @default.
- W2170746223 cites W1968863014 @default.
- W2170746223 cites W1974824671 @default.
- W2170746223 cites W1976541921 @default.
- W2170746223 cites W1979717870 @default.
- W2170746223 cites W1981364522 @default.
- W2170746223 cites W1988725105 @default.
- W2170746223 cites W1991738959 @default.
- W2170746223 cites W1993631712 @default.
- W2170746223 cites W1996037543 @default.
- W2170746223 cites W1999352359 @default.
- W2170746223 cites W2001034344 @default.
- W2170746223 cites W2002294810 @default.
- W2170746223 cites W2010841889 @default.
- W2170746223 cites W2012222703 @default.
- W2170746223 cites W2013290065 @default.
- W2170746223 cites W2015666335 @default.
- W2170746223 cites W2017542358 @default.
- W2170746223 cites W2018086608 @default.
- W2170746223 cites W2022307934 @default.
- W2170746223 cites W2022640173 @default.
- W2170746223 cites W2025538956 @default.
- W2170746223 cites W2026627585 @default.
- W2170746223 cites W2027724328 @default.
- W2170746223 cites W2028909201 @default.
- W2170746223 cites W2031704456 @default.
- W2170746223 cites W2037673353 @default.
- W2170746223 cites W2038206572 @default.
- W2170746223 cites W2039558707 @default.
- W2170746223 cites W2049100687 @default.
- W2170746223 cites W2051478150 @default.
- W2170746223 cites W2052407144 @default.
- W2170746223 cites W2052735278 @default.
- W2170746223 cites W2053018813 @default.
- W2170746223 cites W2055594286 @default.
- W2170746223 cites W2060445364 @default.
- W2170746223 cites W2060862592 @default.
- W2170746223 cites W2061627146 @default.
- W2170746223 cites W2062402497 @default.
- W2170746223 cites W2064738827 @default.
- W2170746223 cites W2066029007 @default.
- W2170746223 cites W2067490563 @default.
- W2170746223 cites W2069206441 @default.
- W2170746223 cites W2070074576 @default.
- W2170746223 cites W2070345064 @default.
- W2170746223 cites W2071385796 @default.
- W2170746223 cites W2074450563 @default.
- W2170746223 cites W2074537715 @default.
- W2170746223 cites W2075160462 @default.
- W2170746223 cites W2075188736 @default.
- W2170746223 cites W2076067526 @default.
- W2170746223 cites W2085792819 @default.
- W2170746223 cites W2087408808 @default.
- W2170746223 cites W2087843844 @default.
- W2170746223 cites W2095853585 @default.
- W2170746223 cites W2097545739 @default.
- W2170746223 cites W2103269753 @default.
- W2170746223 cites W2106476912 @default.
- W2170746223 cites W2108494397 @default.
- W2170746223 cites W2110179176 @default.
- W2170746223 cites W2110584203 @default.
- W2170746223 cites W2113146102 @default.
- W2170746223 cites W2116281863 @default.
- W2170746223 cites W2116448165 @default.
- W2170746223 cites W2129291128 @default.
- W2170746223 cites W2130358771 @default.
- W2170746223 cites W2131810438 @default.
- W2170746223 cites W2136559125 @default.
- W2170746223 cites W2140929617 @default.
- W2170746223 cites W2144273781 @default.
- W2170746223 cites W2145005310 @default.
- W2170746223 cites W2147028771 @default.
- W2170746223 cites W2151892297 @default.
- W2170746223 cites W2152740168 @default.
- W2170746223 cites W2170853655 @default.
- W2170746223 cites W2171561168 @default.
- W2170746223 cites W2171896347 @default.
- W2170746223 cites W2329570584 @default.
- W2170746223 cites W2914916551 @default.
- W2170746223 cites W4205488307 @default.
- W2170746223 cites W4253384824 @default.
- W2170746223 cites W4253580260 @default.
- W2170746223 cites W4328001085 @default.
- W2170746223 doi "https://doi.org/10.1152/ajpgi.00493.2012" @default.
- W2170746223 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3680683" @default.