Matches in SemOpenAlex for { <https://semopenalex.org/work/W2170759073> ?p ?o ?g. }
- W2170759073 endingPage "64" @default.
- W2170759073 startingPage "47" @default.
- W2170759073 abstract "Abstract Telomere position effects on transcription (TPE, or telomeric silencing) are nucleated by association of nonhistone silencing factors with the telomere and propagated in subtelomeric regions through association of silencing factors with the specifically modified histones H3 and H4. However, the function of histone H2A in TPE is unknown. We found that deletion of either the amino or the carboxyltails of H2A substantially reduces TPE. We identified four H2A modification sites necessary for wild-type efficiency of TPE. These “hta1tpe” alleles also act as suppressors of a δ insertion allele of LYS2, suggesting shared elements of chromatin structure at both loci. Interestingly, we observed combinatorial effects of allele pairs, suggesting both interdependent acetylation and deacetylation events in the amino-terminal tail and a regulatory circuit between multiple phosphorylated residues in the carboxyl-terminal tail. Decreases in silencing and viability are observed in most hta1tpe alleles after treatment with low and high concentrations, respectively, of bleomycin, which forms double-strand breaks (DSBs). In the absence of the DSB and telomere-binding protein yKu70, the bleomycin sensitivity of hta1tpe alleles is further enhanced. We also provide data suggesting the presence of a yKu-dependent histone H2A function in TPE. These data indicate that the amino- and carboxyl-terminal tails of H2A are essential for wild-type levels of yKu-mediated TPE and DSB repair." @default.
- W2170759073 created "2016-06-24" @default.
- W2170759073 creator A5012132645 @default.
- W2170759073 creator A5031058670 @default.
- W2170759073 creator A5067648304 @default.
- W2170759073 creator A5082427748 @default.
- W2170759073 date "2003-05-01" @default.
- W2170759073 modified "2023-09-30" @default.
- W2170759073 title "Multiple Roles for <i>Saccharomyces cerevisiae</i> Histone H2A in Telomere Position Effect, Spt Phenotypes and Double-Strand-Break Repair" @default.
- W2170759073 cites W1495746426 @default.
- W2170759073 cites W1518422217 @default.
- W2170759073 cites W1564224574 @default.
- W2170759073 cites W1603793127 @default.
- W2170759073 cites W1629804770 @default.
- W2170759073 cites W1754822275 @default.
- W2170759073 cites W1798907412 @default.
- W2170759073 cites W1824385762 @default.
- W2170759073 cites W1832789965 @default.
- W2170759073 cites W1913652972 @default.
- W2170759073 cites W1964170914 @default.
- W2170759073 cites W1967209407 @default.
- W2170759073 cites W1969671007 @default.
- W2170759073 cites W1970447674 @default.
- W2170759073 cites W1970599000 @default.
- W2170759073 cites W1971458488 @default.
- W2170759073 cites W1973157808 @default.
- W2170759073 cites W1974890383 @default.
- W2170759073 cites W1976561164 @default.
- W2170759073 cites W1976939918 @default.
- W2170759073 cites W1977063849 @default.
- W2170759073 cites W1979245113 @default.
- W2170759073 cites W1979944682 @default.
- W2170759073 cites W1985544638 @default.
- W2170759073 cites W1985914869 @default.
- W2170759073 cites W1986764201 @default.
- W2170759073 cites W1995111407 @default.
- W2170759073 cites W1997818262 @default.
- W2170759073 cites W2000737623 @default.
- W2170759073 cites W2003312750 @default.
- W2170759073 cites W2003379794 @default.
- W2170759073 cites W2004010498 @default.
- W2170759073 cites W2006094963 @default.
- W2170759073 cites W2030907755 @default.
- W2170759073 cites W2034564804 @default.
- W2170759073 cites W2037036397 @default.
- W2170759073 cites W2040542961 @default.
- W2170759073 cites W2041336616 @default.
- W2170759073 cites W2044681616 @default.
- W2170759073 cites W2045390356 @default.
- W2170759073 cites W2049512371 @default.
- W2170759073 cites W2050691074 @default.
- W2170759073 cites W2056727374 @default.
- W2170759073 cites W2058346978 @default.
- W2170759073 cites W2062630554 @default.
- W2170759073 cites W2062654525 @default.
- W2170759073 cites W2065443565 @default.
- W2170759073 cites W2070271611 @default.
- W2170759073 cites W2070614630 @default.
- W2170759073 cites W2075202222 @default.
- W2170759073 cites W2083487776 @default.
- W2170759073 cites W2085216777 @default.
- W2170759073 cites W2085631727 @default.
- W2170759073 cites W2088974911 @default.
- W2170759073 cites W2097948853 @default.
- W2170759073 cites W2098850697 @default.
- W2170759073 cites W2100941051 @default.
- W2170759073 cites W2105721989 @default.
- W2170759073 cites W2106317558 @default.
- W2170759073 cites W2106336456 @default.
- W2170759073 cites W2106795964 @default.
- W2170759073 cites W2107664472 @default.
- W2170759073 cites W2109998847 @default.
- W2170759073 cites W2111217339 @default.
- W2170759073 cites W2134955680 @default.
- W2170759073 cites W2135342180 @default.
- W2170759073 cites W2139527487 @default.
- W2170759073 cites W2140948740 @default.
- W2170759073 cites W2143658931 @default.
- W2170759073 cites W2144792857 @default.
- W2170759073 cites W2149424329 @default.
- W2170759073 cites W2149752144 @default.
- W2170759073 cites W2150104152 @default.
- W2170759073 cites W2157190630 @default.
- W2170759073 cites W2157451489 @default.
- W2170759073 cites W2161824574 @default.
- W2170759073 cites W2163235941 @default.
- W2170759073 cites W2163571866 @default.
- W2170759073 cites W2168562183 @default.
- W2170759073 cites W2169811180 @default.
- W2170759073 cites W2172290898 @default.
- W2170759073 cites W4249687807 @default.
- W2170759073 cites W4253230931 @default.
- W2170759073 cites W80729437 @default.
- W2170759073 doi "https://doi.org/10.1093/genetics/164.1.47" @default.
- W2170759073 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1462545" @default.
- W2170759073 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12750320" @default.
- W2170759073 hasPublicationYear "2003" @default.
- W2170759073 type Work @default.