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• W2170761929 endingPage "5098" @default.
• W2170761929 startingPage "5090" @default.
• W2170761929 abstract "Multiple sclerosis (MS) is a demyelinating inflammatory disease of the CNS. Though originally believed to be CD4-mediated, additional immune effector mechanisms, including myelin-specific CD8(+) T cells, are now proposed to participate in the pathophysiology of MS. To study the immunologic and encephalitogenic behavior of HLA-A*0201-binding myelin-derived epitopes in vivo, we used a humanized HLA-A*0201-transgenic mouse model. Eight HLA-A*0201-binding peptides derived from myelin oligodendrocyte glycoprotein (MOG), an immunodominant myelin self-Ag, were identified in silico. After establishing their relative affinity for HLA-A*0201 and their capacity to form stable complexes with HLA-A*0201 in vitro, their immunological characteristics were studied in HLA-A*0201-transgenic mice. Five MOG peptides, which bound stably to HLA-A*0201 exhibited strong immunogenicity by inducing a sizeable MOG-specific HLA-A*0201-restricted CD8(+) T cell response in vivo. Of these five candidate epitopes, four were processed by MOG-transfected RMA target cells and two peptides proved immunodominant in vivo in response to a plasmid-encoding native full-length MOG. One of the immunodominant MOG peptides (MOG(181)) generated a cytotoxic CD8(+) T cell response able to aggravate CD4(+)-mediated EAE. Therefore, this detailed in vivo characterization provides a hierarchy of candidate epitopes for MOG-specific CD8(+) T cell responses in HLA-A*0201 MS patients identifying the encephalitogenic MOG(181) epitope as a primary candidate." @default.
• W2170761929 created "2016-06-24" @default.
• W2170761929 creator A5000860494 @default.
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• W2170761929 date "2007-10-15" @default.
• W2170761929 modified "2023-10-03" @default.
• W2170761929 title "CD8 T Cell Responses to Myelin Oligodendrocyte Glycoprotein-Derived Peptides in Humanized HLA-A*0201-Transgenic Mice" @default.
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• W2170761929 cites W1675195038 @default.
• W2170761929 cites W1769453339 @default.
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• W2170761929 doi "https://doi.org/10.4049/jimmunol.179.8.5090" @default.
• W2170761929 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17911594" @default.
• W2170761929 hasPublicationYear "2007" @default.
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