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- W2170775439 abstract "The optical isomers of 2-aminomethylpyrrolidine(1,1-cyclobutane-dicarboxylato)platinum(II) (DWA2114, 1), which has potent antitumor activity against various tumors, were synthesized. They were examined for antitumor activity against Colon 26 carcinoma in a sc-iv system, and changes in urinary protein and sugar levels in drug-treated mice were used as an index of nephrotoxicity. In their effect on tumors, (+)-(S)-2-aminomethylpyrrolidine(1,1-cyclobutanedicarboxylato)platinum (II) (6b) was more potent than the enantiomer 6a in that the effective dose of 6b was smaller than that of 6a; but, both drugs exhibited potent antitumor activity. On the other hand, a distinct difference between 6a and 6b was shown in their nephrotoxicity. Isomer 6b induced a great increase in urinary protein and sugar levels in mice, whereas 6a caused no increase in these levels." @default.
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- W2170775439 date "1991-09-01" @default.
- W2170775439 modified "2023-09-26" @default.
- W2170775439 title "Synthesis, Antitumor Activity, and Nephrotoxicity of the Optical Isomers of 2-Aminomethylpyrrolidine(1,1-cyclobutane-dicarboxylato)platinum(II)" @default.
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- W2170775439 doi "https://doi.org/10.1002/jps.2600800907" @default.
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