FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2170786340> ?p ?o ?g. }

• W2170786340 endingPage "2971" @default.
• W2170786340 startingPage "2965" @default.
• W2170786340 abstract "Warfarin prevents stroke in atrial fibrillation (AF); however, concerns regarding international normalized ratio control and hemorrhage limit its use in the elderly. The oral direct thrombin inhibitors (DTIs) are potential alternatives to warfarin, offering fixed dosing without drug and dietary interactions and the need for international normalized ratio monitoring. Although ximelagatran, a DTI studied in the Stroke Prevention using an ORal Thrombin Inhibitor in atrial Fibrillation trials, has been withdrawn, development of other DTIs continues. We report our experience in elderly high-risk AF patients on ximelagatran compared with warfarin therapy.Data from patients with AF and stroke risk factors randomized in Stroke Prevention using an ORal Thrombin Inhibitor in atrial Fibrillation III and V trials to ximelagatran or warfarin were analyzed for stroke/systemic emboli, bleeding, and raised alanine aminotransferase levels in those >or=75 (n=2804) and <75 (n=4525) years.Ximelagatran was as effective as warfarin in reducing stroke/systemic emboli in the elderly (2.23%/y with ximelagatran vs 2.27%/y with warfarin) as in younger patients (1.25%/y vs 1.28%/y). Total bleeds were significantly lower with ximelagatran compared with warfarin in elderly (40% vs 45%, P=0.01) and younger (27% vs 35%, P<0.001) patients. Raised alanine aminotransferase values (>3-fold elevation) among ximelagatran patients were more common in older (7.5% old vs 5.3% young) patients, particularly women (9.5% elderly women vs 6.1% elderly men).In high-risk elderly AF patients, ximelagatran is as effective as warfarin with less bleeding, but alanine aminotransferase elevations are common, particularly in elderly women. Oral DTIs for stroke prevention show promise in elderly patients." @default.
• W2170786340 created "2016-06-24" @default.
• W2170786340 creator A5003802196 @default.
• W2170786340 creator A5013931283 @default.
• W2170786340 creator A5021274752 @default.
• W2170786340 creator A5036890206 @default.
• W2170786340 creator A5045035846 @default.
• W2170786340 creator A5062319122 @default.
• W2170786340 creator A5064918196 @default.
• W2170786340 creator A5078294568 @default.
• W2170786340 date "2007-11-01" @default.
• W2170786340 modified "2023-10-10" @default.
• W2170786340 title "Direct Thrombin Inhibition and Stroke Prevention in Elderly Patients With Atrial Fibrillation" @default.
• W2170786340 cites W1522894564 @default.
• W2170786340 cites W1565918379 @default.
• W2170786340 cites W1738640266 @default.
• W2170786340 cites W1804375307 @default.
• W2170786340 cites W1967046500 @default.
• W2170786340 cites W1979437648 @default.
• W2170786340 cites W1994894525 @default.
• W2170786340 cites W2004603572 @default.
• W2170786340 cites W2006269130 @default.
• W2170786340 cites W2015398317 @default.
• W2170786340 cites W2023487444 @default.
• W2170786340 cites W2036605610 @default.
• W2170786340 cites W2045511665 @default.
• W2170786340 cites W2066490209 @default.
• W2170786340 cites W2111979976 @default.
• W2170786340 cites W2124882362 @default.
• W2170786340 cites W2158086311 @default.
• W2170786340 cites W2261476326 @default.
• W2170786340 cites W4245449645 @default.
• W2170786340 doi "https://doi.org/10.1161/strokeaha.107.488007" @default.
• W2170786340 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17885258" @default.
• W2170786340 hasPublicationYear "2007" @default.
• W2170786340 type Work @default.
• W2170786340 sameAs 2170786340 @default.
• W2170786340 citedByCount "20" @default.
• W2170786340 countsByYear W21707863402012 @default.
• W2170786340 countsByYear W21707863402013 @default.
• W2170786340 countsByYear W21707863402014 @default.
• W2170786340 countsByYear W21707863402015 @default.
• W2170786340 countsByYear W21707863402017 @default.
• W2170786340 countsByYear W21707863402018 @default.
• W2170786340 countsByYear W21707863402019 @default.
• W2170786340 crossrefType "journal-article" @default.
• W2170786340 hasAuthorship W2170786340A5003802196 @default.
• W2170786340 hasAuthorship W2170786340A5013931283 @default.
• W2170786340 hasAuthorship W2170786340A5021274752 @default.
• W2170786340 hasAuthorship W2170786340A5036890206 @default.
• W2170786340 hasAuthorship W2170786340A5045035846 @default.
• W2170786340 hasAuthorship W2170786340A5062319122 @default.
• W2170786340 hasAuthorship W2170786340A5064918196 @default.
• W2170786340 hasAuthorship W2170786340A5078294568 @default.
• W2170786340 hasBestOaLocation W21707863401 @default.
• W2170786340 hasConcept C126322002 @default.
• W2170786340 hasConcept C127413603 @default.
• W2170786340 hasConcept C164705383 @default.
• W2170786340 hasConcept C2776301958 @default.
• W2170786340 hasConcept C2776710957 @default.
• W2170786340 hasConcept C2777288759 @default.
• W2170786340 hasConcept C2777292125 @default.
• W2170786340 hasConcept C2778810321 @default.
• W2170786340 hasConcept C2779161974 @default.
• W2170786340 hasConcept C2779630707 @default.
• W2170786340 hasConcept C2780645631 @default.
• W2170786340 hasConcept C42219234 @default.
• W2170786340 hasConcept C57002609 @default.
• W2170786340 hasConcept C71924100 @default.
• W2170786340 hasConcept C78519656 @default.
• W2170786340 hasConcept C89560881 @default.
• W2170786340 hasConceptScore W2170786340C126322002 @default.
• W2170786340 hasConceptScore W2170786340C127413603 @default.
• W2170786340 hasConceptScore W2170786340C164705383 @default.
• W2170786340 hasConceptScore W2170786340C2776301958 @default.
• W2170786340 hasConceptScore W2170786340C2776710957 @default.
• W2170786340 hasConceptScore W2170786340C2777288759 @default.
• W2170786340 hasConceptScore W2170786340C2777292125 @default.
• W2170786340 hasConceptScore W2170786340C2778810321 @default.
• W2170786340 hasConceptScore W2170786340C2779161974 @default.
• W2170786340 hasConceptScore W2170786340C2779630707 @default.
• W2170786340 hasConceptScore W2170786340C2780645631 @default.
• W2170786340 hasConceptScore W2170786340C42219234 @default.
• W2170786340 hasConceptScore W2170786340C57002609 @default.
• W2170786340 hasConceptScore W2170786340C71924100 @default.
• W2170786340 hasConceptScore W2170786340C78519656 @default.
• W2170786340 hasConceptScore W2170786340C89560881 @default.
• W2170786340 hasIssue "11" @default.
• W2170786340 hasLocation W21707863401 @default.
• W2170786340 hasLocation W21707863402 @default.
• W2170786340 hasOpenAccess W2170786340 @default.
• W2170786340 hasPrimaryLocation W21707863401 @default.
• W2170786340 hasRelatedWork W1995818964 @default.
• W2170786340 hasRelatedWork W2021313919 @default.
• W2170786340 hasRelatedWork W2035416678 @default.
• W2170786340 hasRelatedWork W2065613124 @default.
• W2170786340 hasRelatedWork W2065624675 @default.
• W2170786340 hasRelatedWork W2170786340 @default.

• next