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- W2170791685 abstract "Regional cerebral glucose hypometabolism as well as abnormal levels of cerebrospinal fluid (CSF) proteins amyloid beta (Aß), total (t-tau) and phosphorylated tau (p-tau) are established biomarkers of Alzheimer's disease (AD). In this single-center cross-sectional study we examined relationships between these biomarkers and with disease severity. Seventy one patient (MMSE 23.3±4.1) with amnestic mild cognitive impairment (aMCI) (n = 35) and probable AD (n = 36) underwent positron emission tomography with [18F]-fluorodeoxyglucose (FDG-PET), lumbar puncture for CSF Aß1-42, t-tau, p-tau181, and blood analysis for ApoE genotype. All findings were classified as positive or negative for AD. In the whole patient sample (n = 71), the agreement with FDG-PET was 70.4% (chance-corrected kappa [k] = 0.39, p<0.001) for t-tau, 60.6% (k = 0.27, p = 0.005) for Aß1-42, 63.4% for p-tau181 (k = 0.22, n.s.), and 62.0% for ApoE genotype (k = 0.22, n.s.). Among potential predictors and confounders, t-tau and Aß1-42 significantly (p<0.05) predicted the FDG-PET finding in the whole sample. After accounting for the diagnostic category, t-tau remained the only significant predictor. MMSE score significantly (p<0.05) correlated with FDG-PET (r = −0.55), t-tau (r = −0.45), and p-tau181 (r = −0.30). To the best of our knowledge this is the largest study that explored the relationships between FDG-PET and CSF makers in MCI and AD to date. Another merit of this study is its naturalistic design with all participants and procedures being part of the routine clinical practice. Finally, all data presented have been acquired and treated in one single center, thus avoiding problematic issues related to intercenter variations in data acquisition, handling, and patient assessments. Among three CSF peptides t-tau was most closely related to FDG-PET, in general supporting the recently proposed model of dynamic biomarkers changes, according to which synaptic dysfunction (as measured by FDG-PET) and neuronal injury (as measured by CSF tau levels) are both markers of neurodegeneration. The neurobiological proximity of these biomarkers is reinforced by a close association of both with disease severity. Yet, the overall agreement of 70% seems insufficient to justify interchangeability of these biomarkers in clinical practice. Indirectly, this observation furthermore suggests that these biomarkers may independently contribute to diagnostic classification." @default.
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- W2170791685 date "2011-07-01" @default.
- W2170791685 modified "2023-10-06" @default.
- W2170791685 title "P1-128: FDG-PET and CSF proteins: Are these Alzheimer's disease biomarkers interchangeable?" @default.
- W2170791685 doi "https://doi.org/10.1016/j.jalz.2011.05.408" @default.
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