FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2170800424> ?p ?o ?g. }

• W2170800424 endingPage "1296" @default.
• W2170800424 startingPage "1291" @default.
• W2170800424 abstract "<b>Background:</b> Sulfhydryl (SH) compounds are essential in maintaining mucosal integrity in the gastrointestinal tract. A decrease in colonic mucosal SH compounds affects the redox status of the mucosa, resulting in vulnerability to further attacks. Therefore, there is a strong need for in vivo evaluation of SH compounds in the colonic mucosa. <b>Aims:</b> The aim of the current study was to establish a method of evaluating levels of SH compounds in the colonic mucosa of live animals before and after induction of colitis. <b>Methods:</b> Murine experimental colitis was induced by instillation of trinitrobenzene sulphonic acid (TNBS) dissolved in 50% ethanol into the colon via the anus. For evaluation of mucosal SH compounds in the colon, 3-carbamoyl-2,2,5,5-tetramethylpyrrolidine-1-oxyl (carbamoyl-PROXYL), a stable nitroxide radical, was instilled into the colonic lumen of live mice and the spin clearance rate was measured by L-band electron spin resonance (ESR) spectroscopy. <b>Results:</b> Morphological study showed that mucosal damage was severe one or two days after TNBS instillation. The colonic mucosa started to regenerate at four days, and looked normal at seven days, after induction of colitis. The spin clearance rate of carbamoyl-PROXYL decreased significantly at 0.5, 1, 2, and 4 days after induction of colitis compared with mice before TNBS instillation. Surprisingly, although the colonic mucosa looked normal seven days after TNBS administration, the spin clearance rate still remained significantly slow. The spin clearance rate returned to normal 14 days after induction of colitis. The change in in vivo spin clearance rate was consistent with the time dependent change in mucosal reduced glutathione, a major component of SH compounds. <b>Conclusion:</b> The spin clearance rate obtained by L-band ESR spectroscopy in combination with carbamoyl-PROXYL can give an estimate of the level of colonic mucosal SH compounds in live animals and is useful for evaluating the mucosal defence system against oxidative stress." @default.
• W2170800424 created "2016-06-24" @default.
• W2170800424 creator A5013301564 @default.
• W2170800424 creator A5013380810 @default.
• W2170800424 creator A5017962612 @default.
• W2170800424 creator A5019822231 @default.
• W2170800424 creator A5025473231 @default.
• W2170800424 creator A5043480435 @default.
• W2170800424 creator A5059026718 @default.
• W2170800424 creator A5059646272 @default.
• W2170800424 creator A5068281810 @default.
• W2170800424 creator A5073172050 @default.
• W2170800424 creator A5075847590 @default.
• W2170800424 creator A5078419544 @default.
• W2170800424 creator A5080549041 @default.
• W2170800424 date "2003-09-01" @default.
• W2170800424 modified "2023-09-30" @default.
• W2170800424 title "Mucosal sulfhydryl compounds evaluation by in vivo electron spin resonance spectroscopy in mice with experimental colitis" @default.
• W2170800424 cites W1516172894 @default.
• W2170800424 cites W1523941392 @default.
• W2170800424 cites W1824813420 @default.
• W2170800424 cites W1967648648 @default.
• W2170800424 cites W1969204755 @default.
• W2170800424 cites W1972987064 @default.
• W2170800424 cites W1975168158 @default.
• W2170800424 cites W1989803926 @default.
• W2170800424 cites W2012083687 @default.
• W2170800424 cites W2015776166 @default.
• W2170800424 cites W2028025555 @default.
• W2170800424 cites W2030912682 @default.
• W2170800424 cites W2050782978 @default.
• W2170800424 cites W2056511200 @default.
• W2170800424 cites W2057872261 @default.
• W2170800424 cites W2069132215 @default.
• W2170800424 cites W2069472071 @default.
• W2170800424 cites W2077131562 @default.
• W2170800424 cites W2110069919 @default.
• W2170800424 cites W2112679274 @default.
• W2170800424 cites W2113472065 @default.
• W2170800424 cites W2141679700 @default.
• W2170800424 cites W2160527898 @default.
• W2170800424 cites W2162932896 @default.
• W2170800424 cites W2410131303 @default.
• W2170800424 doi "https://doi.org/10.1136/gut.52.9.1291" @default.
• W2170800424 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1773775" @default.
• W2170800424 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12912860" @default.
• W2170800424 hasPublicationYear "2003" @default.
• W2170800424 type Work @default.
• W2170800424 sameAs 2170800424 @default.
• W2170800424 citedByCount "13" @default.
• W2170800424 countsByYear W21708004242015 @default.
• W2170800424 countsByYear W21708004242016 @default.
• W2170800424 countsByYear W21708004242018 @default.
• W2170800424 countsByYear W21708004242019 @default.
• W2170800424 countsByYear W21708004242020 @default.
• W2170800424 crossrefType "journal-article" @default.
• W2170800424 hasAuthorship W2170800424A5013301564 @default.
• W2170800424 hasAuthorship W2170800424A5013380810 @default.
• W2170800424 hasAuthorship W2170800424A5017962612 @default.
• W2170800424 hasAuthorship W2170800424A5019822231 @default.
• W2170800424 hasAuthorship W2170800424A5025473231 @default.
• W2170800424 hasAuthorship W2170800424A5043480435 @default.
• W2170800424 hasAuthorship W2170800424A5059026718 @default.
• W2170800424 hasAuthorship W2170800424A5059646272 @default.
• W2170800424 hasAuthorship W2170800424A5068281810 @default.
• W2170800424 hasAuthorship W2170800424A5073172050 @default.
• W2170800424 hasAuthorship W2170800424A5075847590 @default.
• W2170800424 hasAuthorship W2170800424A5078419544 @default.
• W2170800424 hasAuthorship W2170800424A5080549041 @default.
• W2170800424 hasBestOaLocation W21708004241 @default.
• W2170800424 hasConcept C126322002 @default.
• W2170800424 hasConcept C142724271 @default.
• W2170800424 hasConcept C150903083 @default.
• W2170800424 hasConcept C185592680 @default.
• W2170800424 hasConcept C207001950 @default.
• W2170800424 hasConcept C2775862500 @default.
• W2170800424 hasConcept C2780512811 @default.
• W2170800424 hasConcept C3019368612 @default.
• W2170800424 hasConcept C71924100 @default.
• W2170800424 hasConcept C86803240 @default.
• W2170800424 hasConcept C90924648 @default.
• W2170800424 hasConceptScore W2170800424C126322002 @default.
• W2170800424 hasConceptScore W2170800424C142724271 @default.
• W2170800424 hasConceptScore W2170800424C150903083 @default.
• W2170800424 hasConceptScore W2170800424C185592680 @default.
• W2170800424 hasConceptScore W2170800424C207001950 @default.
• W2170800424 hasConceptScore W2170800424C2775862500 @default.
• W2170800424 hasConceptScore W2170800424C2780512811 @default.
• W2170800424 hasConceptScore W2170800424C3019368612 @default.
• W2170800424 hasConceptScore W2170800424C71924100 @default.
• W2170800424 hasConceptScore W2170800424C86803240 @default.
• W2170800424 hasConceptScore W2170800424C90924648 @default.
• W2170800424 hasIssue "9" @default.
• W2170800424 hasLocation W21708004241 @default.
• W2170800424 hasLocation W21708004242 @default.
• W2170800424 hasLocation W21708004243 @default.
• W2170800424 hasLocation W21708004244 @default.
• W2170800424 hasLocation W21708004245 @default.

• next