Matches in SemOpenAlex for { <https://semopenalex.org/work/W2170802261> ?p ?o ?g. }
- W2170802261 endingPage "bar021" @default.
- W2170802261 startingPage "bar021" @default.
- W2170802261 abstract "Receptor activator of nuclear factor-kappa B ligand (RANKL) is a member of tumor necrosis factor (TNF) superfamily that plays a key role in the regulation of differentiation, activation and survival of osteoclasts and also in tumor cell migration and bone metastasis. Osteoclast activation induced by RANKL regulates hematopoietic stem cell mobilization as part of homeostasis and host defense mechanisms thereby linking regulation of hematopoiesis with bone remodeling. Binding of RANKL to its receptor, Receptor activator of nuclear factor-kappa B (RANK) activates molecules such as NF-kappa B, mitogen activated protein kinase (MAPK), nuclear factor of activated T cells (NFAT) and phosphatidyl 3-kinase (PI3K). Although the molecular and cellular roles of these molecules have been reported previously, a systematic cataloging of the molecular events induced by RANKL/RANK interaction has not been attempted. Here, we present a comprehensive reaction map of the RANKL/RANK-signaling pathway based on an extensive manual curation of the published literature. We hope that the curated RANKL/RANK-signaling pathway model would enable new biomedical discoveries, which can provide novel insights into disease processes and development of novel therapeutic interventions." @default.
- W2170802261 created "2016-06-24" @default.
- W2170802261 creator A5003467194 @default.
- W2170802261 creator A5010789029 @default.
- W2170802261 creator A5011813928 @default.
- W2170802261 creator A5013247873 @default.
- W2170802261 creator A5015742394 @default.
- W2170802261 creator A5016030548 @default.
- W2170802261 creator A5018605685 @default.
- W2170802261 creator A5024268602 @default.
- W2170802261 creator A5034253110 @default.
- W2170802261 creator A5034750707 @default.
- W2170802261 creator A5041712526 @default.
- W2170802261 creator A5044173736 @default.
- W2170802261 creator A5056436500 @default.
- W2170802261 creator A5061013881 @default.
- W2170802261 creator A5064765384 @default.
- W2170802261 creator A5091557016 @default.
- W2170802261 date "2011-07-08" @default.
- W2170802261 modified "2023-10-16" @default.
- W2170802261 title "A comprehensive manually curated reaction map of RANKL/RANK-signaling pathway" @default.
- W2170802261 cites W1584990959 @default.
- W2170802261 cites W1650001464 @default.
- W2170802261 cites W1964650077 @default.
- W2170802261 cites W1964914796 @default.
- W2170802261 cites W1966493197 @default.
- W2170802261 cites W1969709265 @default.
- W2170802261 cites W1979481937 @default.
- W2170802261 cites W1987368791 @default.
- W2170802261 cites W1988102812 @default.
- W2170802261 cites W1994403682 @default.
- W2170802261 cites W1996372998 @default.
- W2170802261 cites W1999077925 @default.
- W2170802261 cites W2000170431 @default.
- W2170802261 cites W2000647744 @default.
- W2170802261 cites W2002315265 @default.
- W2170802261 cites W2006933206 @default.
- W2170802261 cites W2012634952 @default.
- W2170802261 cites W2014258794 @default.
- W2170802261 cites W2015456782 @default.
- W2170802261 cites W2018450202 @default.
- W2170802261 cites W2021063762 @default.
- W2170802261 cites W2023245305 @default.
- W2170802261 cites W2026889273 @default.
- W2170802261 cites W2031874549 @default.
- W2170802261 cites W2033069193 @default.
- W2170802261 cites W2045856882 @default.
- W2170802261 cites W2051320963 @default.
- W2170802261 cites W2060482009 @default.
- W2170802261 cites W2065297127 @default.
- W2170802261 cites W2072139946 @default.
- W2170802261 cites W2072510816 @default.
- W2170802261 cites W2073472143 @default.
- W2170802261 cites W2085419497 @default.
- W2170802261 cites W2093521183 @default.
- W2170802261 cites W2094374305 @default.
- W2170802261 cites W2095546640 @default.
- W2170802261 cites W2106323366 @default.
- W2170802261 cites W2111759218 @default.
- W2170802261 cites W2116815941 @default.
- W2170802261 cites W2119838074 @default.
- W2170802261 cites W2120837197 @default.
- W2170802261 cites W2121778907 @default.
- W2170802261 cites W2122863289 @default.
- W2170802261 cites W2124036292 @default.
- W2170802261 cites W2125679885 @default.
- W2170802261 cites W2127743278 @default.
- W2170802261 cites W2137486655 @default.
- W2170802261 cites W2138486090 @default.
- W2170802261 cites W2139996507 @default.
- W2170802261 cites W2141070796 @default.
- W2170802261 cites W2141545183 @default.
- W2170802261 cites W2150908245 @default.
- W2170802261 cites W2151480907 @default.
- W2170802261 cites W2153865301 @default.
- W2170802261 cites W2156907249 @default.
- W2170802261 cites W2159675211 @default.
- W2170802261 cites W2161682775 @default.
- W2170802261 cites W2164750538 @default.
- W2170802261 cites W2167253023 @default.
- W2170802261 cites W2169366408 @default.
- W2170802261 cites W2171599819 @default.
- W2170802261 cites W2460699960 @default.
- W2170802261 cites W4239262626 @default.
- W2170802261 cites W4254214228 @default.
- W2170802261 cites W4255518917 @default.
- W2170802261 doi "https://doi.org/10.1093/database/bar021" @default.
- W2170802261 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3170171" @default.
- W2170802261 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21742767" @default.
- W2170802261 hasPublicationYear "2011" @default.
- W2170802261 type Work @default.
- W2170802261 sameAs 2170802261 @default.
- W2170802261 citedByCount "37" @default.
- W2170802261 countsByYear W21708022612012 @default.
- W2170802261 countsByYear W21708022612013 @default.
- W2170802261 countsByYear W21708022612014 @default.
- W2170802261 countsByYear W21708022612015 @default.
- W2170802261 countsByYear W21708022612016 @default.