FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2170818799> ?p ?o ?g. }

• W2170818799 endingPage "628" @default.
• W2170818799 startingPage "623" @default.
• W2170818799 abstract "<b>Background and aims:</b> Characterisation of the underlying molecular mechanisms that promote Barrett’s progression may ultimately lead to identification of potential predictive genetic markers that classify patients’ malignant risk. In an attempt to understand these causative pathways, fluorescence in situ hybridisation (FISH) was used in this study to determine when specific genetic alterations arise during Barrett’s associated neoplastic progression. <b>Methods:</b> Endoscopic cytology brushings were obtained from 28 patients with Barrett’s metaplasia, 28 with dysplasia (20 low grade dysplasia (LGD) and eight with high grade dysplasia (HGD)), and seven with adenocarcinoma, together with paired control brushings from regions of normal proximal squamous cell epithelium. The exfoliated epithelial cells were washed and deposited onto slides. Probes specific for the centromeres of chromosomes 4, 8, 20, and Y, and locus specific probes for the tumour suppressor genes p16, p53, and Rb were subsequently hybridised. <b>Results:</b> Aneuploidy was found early in progression, with metaplastic tissues displaying increased copy numbers of chromosomes 4 and 8. Chromosome 4 hyperploidy was found in 89%, 90%, 88%, and 100% of metaplasias, LGD, HGD, adenocarcinomas, respectively, while chromosome 8 hyperploidy occurred in 71%, 75%, 100%, and 100% of patients with the respective staging. Loss of the p16 tumour suppressor gene also presented in metaplastic epithelium (7%) but most other genetic aberrations were only seen in HGD. <b>Conclusions:</b> Genetic instability arises well before dysplasia in Barrett’s oesophagus, with chromosome 4 and 8 hyperploidy representing the earliest and most common alterations identified. As these aberrations are widespread at all the premalignant stages, there may be genes on chromosomes 4 and 8 that are involved in both the initiation and progression of Barrett’s oesophagus." @default.
• W2170818799 created "2016-06-24" @default.
• W2170818799 creator A5015398688 @default.
• W2170818799 creator A5024061428 @default.
• W2170818799 creator A5028159336 @default.
• W2170818799 creator A5070500272 @default.
• W2170818799 creator A5071845338 @default.
• W2170818799 creator A5072715482 @default.
• W2170818799 creator A5078887020 @default.
• W2170818799 creator A5082378015 @default.
• W2170818799 creator A5085852837 @default.
• W2170818799 date "2003-05-01" @default.
• W2170818799 modified "2023-09-27" @default.
• W2170818799 title "Chromosome 4 hyperploidy represents an early genetic aberration in premalignant Barrett's oesophagus" @default.
• W2170818799 cites W126870657 @default.
• W2170818799 cites W1573413333 @default.
• W2170818799 cites W1964010321 @default.
• W2170818799 cites W1972336603 @default.
• W2170818799 cites W1972781271 @default.
• W2170818799 cites W1979821364 @default.
• W2170818799 cites W1985338402 @default.
• W2170818799 cites W1986927287 @default.
• W2170818799 cites W1992007850 @default.
• W2170818799 cites W1992669104 @default.
• W2170818799 cites W1992965559 @default.
• W2170818799 cites W2015227466 @default.
• W2170818799 cites W2015782917 @default.
• W2170818799 cites W2032400212 @default.
• W2170818799 cites W2040143851 @default.
• W2170818799 cites W2041758815 @default.
• W2170818799 cites W2055502886 @default.
• W2170818799 cites W2061409978 @default.
• W2170818799 cites W2066903373 @default.
• W2170818799 cites W2068622871 @default.
• W2170818799 cites W2072304364 @default.
• W2170818799 cites W2084825660 @default.
• W2170818799 cites W2089337970 @default.
• W2170818799 cites W2098750893 @default.
• W2170818799 cites W2099584504 @default.
• W2170818799 cites W2105704329 @default.
• W2170818799 cites W212888502 @default.
• W2170818799 cites W2129000565 @default.
• W2170818799 cites W2164923036 @default.
• W2170818799 cites W2170659347 @default.
• W2170818799 cites W2314540303 @default.
• W2170818799 cites W2403739413 @default.
• W2170818799 cites W5701091 @default.
• W2170818799 doi "https://doi.org/10.1136/gut.52.5.623" @default.
• W2170818799 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1773637" @default.
• W2170818799 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12692043" @default.
• W2170818799 hasPublicationYear "2003" @default.
• W2170818799 type Work @default.
• W2170818799 sameAs 2170818799 @default.
• W2170818799 citedByCount "65" @default.
• W2170818799 countsByYear W21708187992012 @default.
• W2170818799 countsByYear W21708187992013 @default.
• W2170818799 countsByYear W21708187992014 @default.
• W2170818799 countsByYear W21708187992015 @default.
• W2170818799 countsByYear W21708187992016 @default.
• W2170818799 countsByYear W21708187992017 @default.
• W2170818799 countsByYear W21708187992020 @default.
• W2170818799 countsByYear W21708187992022 @default.
• W2170818799 crossrefType "journal-article" @default.
• W2170818799 hasAuthorship W2170818799A5015398688 @default.
• W2170818799 hasAuthorship W2170818799A5024061428 @default.
• W2170818799 hasAuthorship W2170818799A5028159336 @default.
• W2170818799 hasAuthorship W2170818799A5070500272 @default.
• W2170818799 hasAuthorship W2170818799A5071845338 @default.
• W2170818799 hasAuthorship W2170818799A5072715482 @default.
• W2170818799 hasAuthorship W2170818799A5078887020 @default.
• W2170818799 hasAuthorship W2170818799A5082378015 @default.
• W2170818799 hasAuthorship W2170818799A5085852837 @default.
• W2170818799 hasBestOaLocation W21708187992 @default.
• W2170818799 hasConcept C104317684 @default.
• W2170818799 hasConcept C121608353 @default.
• W2170818799 hasConcept C140752955 @default.
• W2170818799 hasConcept C142724271 @default.
• W2170818799 hasConcept C180754005 @default.
• W2170818799 hasConcept C2775894508 @default.
• W2170818799 hasConcept C2777542201 @default.
• W2170818799 hasConcept C2778249689 @default.
• W2170818799 hasConcept C2778589982 @default.
• W2170818799 hasConcept C2779357193 @default.
• W2170818799 hasConcept C2779672484 @default.
• W2170818799 hasConcept C2779767149 @default.
• W2170818799 hasConcept C2781182431 @default.
• W2170818799 hasConcept C30481170 @default.
• W2170818799 hasConcept C54355233 @default.
• W2170818799 hasConcept C61320498 @default.
• W2170818799 hasConcept C71924100 @default.
• W2170818799 hasConcept C86803240 @default.
• W2170818799 hasConceptScore W2170818799C104317684 @default.
• W2170818799 hasConceptScore W2170818799C121608353 @default.
• W2170818799 hasConceptScore W2170818799C140752955 @default.
• W2170818799 hasConceptScore W2170818799C142724271 @default.
• W2170818799 hasConceptScore W2170818799C180754005 @default.
• W2170818799 hasConceptScore W2170818799C2775894508 @default.
• W2170818799 hasConceptScore W2170818799C2777542201 @default.

• next