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• W217081934 abstract "ABSTRACT Matrix receptors direct the assembly and retention of the pericellular matrix and provide a linkage to the cytoskeleton. Modulating the link between the cytoskeleton and CD44 might regulate the function of this hyaluronan receptor. Binding of hyaluronan to CD44 retains the hyaluronan/aggrecan aggregates in the pericellular matrix. Also, CD44 turnover is modulated by occupancy with hyaluronan, suggesting that enhanced matrix assembly increases CD44 stability at the cell surface. Using differential detergent extraction, CD44 was localized predominantly in the cytoskeletal-associated pool from matrix-intact chondrocytes. In matrix-depleted chondrocytes, a decrease in this pool with a parallel increase in the detergent soluble pool was detected. CD44-hyaluronan binding may stabilize the chondrocyte cell shape by the interaction of CD44 with the cortical cytoskeleton. Conversely if cytoskeletal elements regulate CD44-hyaluronan binding, disruption of the cytoskeleton may perturb matrix retention. Treatment with either cytochalasin or latrunculin reduced binding of fl-HA and pericellular matrix assembly, but did not reduce CD44 expression by bovine chondrocytes as monitored by flow cytometry. In addition, there was a decrease in the safranin O staining of cytochalasin- and latrunculin-treated cartilage explants indicating the loss of proteoglycan from these tissues as compared to cultured controls. Thus, destabilization of the cytoskeleton may induce changes in the hyaluronan-dependent matrix of chondrocytes." @default.
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• W217081934 date "2002-01-01" @default.
• W217081934 modified "2023-09-27" @default.
• W217081934 title "CD44: THE LINK BETWEEN HYALURONAN AND THE CYTOSKELETON" @default.
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• W217081934 doi "https://doi.org/10.1533/9781845693121.329" @default.
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