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• W2170823745 abstract "Separate measurements of B_max, the density of available receptors, and K_D, the equilibrium dissociation constant in the human brain, with PET have contributed to our understanding of neuropsychiatric disorders, especially with respect to the dopamine D₂/D₃ receptor system. However, existing methods have limited applications to the whole striatum, putamen, or caudate nucleus. Improved methods are required to examine B_max and K_D in detailed functional striatal subdivisions that are becoming widely used. <b>Methods:</b> In response, a new method (bolus-plus-infusion transformation [BPIT]) was developed. After completion of a validation study for ¹¹C-raclopride scans involving 81 subjects, age-associated changes in B_max and K_D were examined in 47 healthy subjects ranging in age from 18 to 77 y. <b>Results:</b> The BPIT method was consistent with established reference tissue methods regarding regional binding potential. BPIT yielded time-consistent estimates of B_max and K_D when scan and infusion lengths were set equal in the analysis. In addition, BPIT was shown to be robust against PET measurement errors when compared with a widely accepted transient equilibrium method. Altogether, BPIT was supported as a method for regional binding potential, B_max, and K_D. We demonstrated age-associated declines in B_max in all 5 functional striatal subdivisions with BPIT when corrected for multiple comparisons. These age-related effects were not consistently attainable with the transient equilibrium method. Irrespective to methods, K_D remained unchanged with age. <b>Conclusion:</b> The BPIT approach may be useful for understanding dopamine receptor abnormalities in neuropsychiatric disorders by enabling separate measurements of B_max and K_D in functional striatal subdivisions." @default.
• W2170823745 created "2016-06-24" @default.
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• W2170823745 date "2012-04-09" @default.
• W2170823745 modified "2023-09-25" @default.
• W2170823745 title "Dissociative Changes in the B_max and K_D of Dopamine D₂/D₃ Receptors with Aging Observed in Functional Subdivisions of the Striatum: A Revisit with an Improved Data Analysis Method" @default.
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• W2170823745 doi "https://doi.org/10.2967/jnumed.111.098186" @default.
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