FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2170825817> ?p ?o ?g. }

• W2170825817 endingPage "1403" @default.
• W2170825817 startingPage "1395" @default.
• W2170825817 abstract "Abstract In vivo studies questioned the ability of Langerhans cells (LCs) to mediate CD8+ T cell priming. To address this issue, we used intradermal immunization with plasmid DNA, a system in which activation of CD8+ T cells depends on delayed kinetics of Ag presentation. We found that dendritic cells (DCs) located in the skin at the time of immunization have limited ability to activate CD8+ T cells. This activity was mediated by a second generation of DCs that differentiated in the skin several days after immunization, as well as by lymph node–resident DCs. Intriguingly, CD8+ T cell responses were not affected following treatment with clodronate liposomes, immunization of CCR2−/− mice, or local neutralization of CCL20. This suggests that local, rather than blood-derived, DC precursors mediate CD8+ T cell priming. Analysis of DC differentiation in the immunized skin revealed a gradual increase in the number of CD11c+ cells, which reached their maximum 2 wk after immunization. A similar differentiation kinetics was observed for LCs, with the majority of differentiating LCs proliferating in situ from epidermal precursors. By using B6/Langerin–diphtheria toxin receptor chimeric mice and LC ablation, we demonstrated that epidermal LCs were crucial for the elicitation of CD8+ T cell responses in vivo. Furthermore, LCs isolated from lymph nodes 2 wk after immunization contained the immunization plasmid and directly activated Ag-specific CD8+ T cells ex vivo. Thus, these results indicate that second-generation Ag-expressing LCs differentiating from epidermal precursors directly prime CD8+ T cells and are essential for optimal cellular immune responses following immunization with plasmid DNA." @default.
• W2170825817 created "2016-06-24" @default.
• W2170825817 creator A5001882403 @default.
• W2170825817 creator A5003962633 @default.
• W2170825817 creator A5013687752 @default.
• W2170825817 creator A5030001672 @default.
• W2170825817 creator A5065853945 @default.
• W2170825817 creator A5073326907 @default.
• W2170825817 creator A5075955922 @default.
• W2170825817 creator A5083229976 @default.
• W2170825817 date "2014-02-15" @default.
• W2170825817 modified "2023-10-13" @default.
• W2170825817 title "Second-Generation Langerhans Cells Originating from Epidermal Precursors Are Essential for CD8+ T Cell Priming" @default.
• W2170825817 cites W1531221353 @default.
• W2170825817 cites W1534033890 @default.
• W2170825817 cites W1557751911 @default.
• W2170825817 cites W1760248554 @default.
• W2170825817 cites W1932988878 @default.
• W2170825817 cites W1969012267 @default.
• W2170825817 cites W1973649497 @default.
• W2170825817 cites W1984275656 @default.
• W2170825817 cites W1994103354 @default.
• W2170825817 cites W1994328363 @default.
• W2170825817 cites W1994654042 @default.
• W2170825817 cites W2011933811 @default.
• W2170825817 cites W2021340733 @default.
• W2170825817 cites W2028653503 @default.
• W2170825817 cites W2031751347 @default.
• W2170825817 cites W2033837180 @default.
• W2170825817 cites W2046289395 @default.
• W2170825817 cites W2053583666 @default.
• W2170825817 cites W2067853799 @default.
• W2170825817 cites W2068556317 @default.
• W2170825817 cites W2079822769 @default.
• W2170825817 cites W2093858925 @default.
• W2170825817 cites W2107378806 @default.
• W2170825817 cites W2108080714 @default.
• W2170825817 cites W2110722277 @default.
• W2170825817 cites W2118815108 @default.
• W2170825817 cites W2119505401 @default.
• W2170825817 cites W2121726659 @default.
• W2170825817 cites W2131746171 @default.
• W2170825817 cites W2150897631 @default.
• W2170825817 cites W2150959582 @default.
• W2170825817 cites W2159401431 @default.
• W2170825817 cites W22670001 @default.
• W2170825817 doi "https://doi.org/10.4049/jimmunol.1301143" @default.
• W2170825817 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24420922" @default.
• W2170825817 hasPublicationYear "2014" @default.
• W2170825817 type Work @default.
• W2170825817 sameAs 2170825817 @default.
• W2170825817 citedByCount "8" @default.
• W2170825817 countsByYear W21708258172014 @default.
• W2170825817 countsByYear W21708258172015 @default.
• W2170825817 countsByYear W21708258172016 @default.
• W2170825817 countsByYear W21708258172017 @default.
• W2170825817 countsByYear W21708258172023 @default.
• W2170825817 crossrefType "journal-article" @default.
• W2170825817 hasAuthorship W2170825817A5001882403 @default.
• W2170825817 hasAuthorship W2170825817A5003962633 @default.
• W2170825817 hasAuthorship W2170825817A5013687752 @default.
• W2170825817 hasAuthorship W2170825817A5030001672 @default.
• W2170825817 hasAuthorship W2170825817A5065853945 @default.
• W2170825817 hasAuthorship W2170825817A5073326907 @default.
• W2170825817 hasAuthorship W2170825817A5075955922 @default.
• W2170825817 hasAuthorship W2170825817A5083229976 @default.
• W2170825817 hasBestOaLocation W21708258171 @default.
• W2170825817 hasConcept C100701293 @default.
• W2170825817 hasConcept C119765067 @default.
• W2170825817 hasConcept C154317977 @default.
• W2170825817 hasConcept C167672396 @default.
• W2170825817 hasConcept C202751555 @default.
• W2170825817 hasConcept C203014093 @default.
• W2170825817 hasConcept C2776090121 @default.
• W2170825817 hasConcept C2778170410 @default.
• W2170825817 hasConcept C2780849966 @default.
• W2170825817 hasConcept C55493867 @default.
• W2170825817 hasConcept C59822182 @default.
• W2170825817 hasConcept C81444415 @default.
• W2170825817 hasConcept C86803240 @default.
• W2170825817 hasConcept C8891405 @default.
• W2170825817 hasConcept C95444343 @default.
• W2170825817 hasConceptScore W2170825817C100701293 @default.
• W2170825817 hasConceptScore W2170825817C119765067 @default.
• W2170825817 hasConceptScore W2170825817C154317977 @default.
• W2170825817 hasConceptScore W2170825817C167672396 @default.
• W2170825817 hasConceptScore W2170825817C202751555 @default.
• W2170825817 hasConceptScore W2170825817C203014093 @default.
• W2170825817 hasConceptScore W2170825817C2776090121 @default.
• W2170825817 hasConceptScore W2170825817C2778170410 @default.
• W2170825817 hasConceptScore W2170825817C2780849966 @default.
• W2170825817 hasConceptScore W2170825817C55493867 @default.
• W2170825817 hasConceptScore W2170825817C59822182 @default.
• W2170825817 hasConceptScore W2170825817C81444415 @default.
• W2170825817 hasConceptScore W2170825817C86803240 @default.
• W2170825817 hasConceptScore W2170825817C8891405 @default.
• W2170825817 hasConceptScore W2170825817C95444343 @default.
• W2170825817 hasIssue "4" @default.

• next