FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2170830738> ?p ?o ?g. }

• W2170830738 endingPage "1306" @default.
• W2170830738 startingPage "1295" @default.
• W2170830738 abstract "The human immunodeficiency virus type 1 (HIV-1) vpu gene encodes a small integral membrane phosphoprotein with two established functions: degradation of the viral coreceptor CD4 in the endoplasmic reticulum (ER) and augmentation of virus particle release from the plasma membrane of HIV-1–infected cells. We show here that Vpu is also largely responsible for the previously observed decrease in the expression of major histocompatibility complex (MHC) class I molecules on the surface of HIV-1–infected cells. Cells infected with HIV-1 isolates that fail to express Vpu, or that express genetically modified forms of Vpu that no longer induce CD4 degradation, exhibit little downregulation of MHC class I molecules. The effect of Vpu on class I biogenesis was analyzed in more detail using a Vpu-expressing recombinant vaccinia virus (VV). VV-expressed Vpu induces the rapid loss of newly synthesized endogenous or VV-expressed class I heavy chains in the ER, detectable either biochemically or by reduced cell surface expression. This effect is of similar rapidity and magnitude as the VV-expressed Vpu-induced degradation of CD4. Vpu had no discernible effects on cell surface expression of VV-expressed mouse CD54, demonstrating the selectivity of its effects on CD4 and class I heavy chains. VVexpressed Vpu does not detectably affect class I molecules that have been exported from the ER. The detrimental effects of Vpu on class I molecules could be distinguished from those caused by VV-expressed herpes virus protein ICP47, which acts by decreasing the supply of cytosolic peptides to class I molecules, indicating that Vpu functions in a distinct manner from ICP47. Based on these findings, we propose that Vpu-induced downregulation of class I molecules may be an important factor in the evolutionary selection of the HIV-1–specific vpu gene by contributing to the inability of CD8+ T cells to eradicate HIV-1 from infected individuals." @default.
• W2170830738 created "2016-06-24" @default.
• W2170830738 creator A5001597543 @default.
• W2170830738 creator A5030635221 @default.
• W2170830738 creator A5070440610 @default.
• W2170830738 creator A5073663836 @default.
• W2170830738 creator A5075012306 @default.
• W2170830738 creator A5079539654 @default.
• W2170830738 creator A5089689630 @default.
• W2170830738 date "1997-04-07" @default.
• W2170830738 modified "2023-10-16" @default.
• W2170830738 title "The Human Immunodeficiency Virus Type 1 (HIV-1) Vpu Protein Interferes with an Early Step in the Biosynthesis of Major Histocompatibility Complex (MHC) Class I Molecules" @default.
• W2170830738 cites W1494978663 @default.
• W2170830738 cites W1498574963 @default.
• W2170830738 cites W1500600550 @default.
• W2170830738 cites W1504625876 @default.
• W2170830738 cites W1514411173 @default.
• W2170830738 cites W1514433785 @default.
• W2170830738 cites W1517021800 @default.
• W2170830738 cites W1534033542 @default.
• W2170830738 cites W1555930389 @default.
• W2170830738 cites W1560893038 @default.
• W2170830738 cites W1571744798 @default.
• W2170830738 cites W1592777545 @default.
• W2170830738 cites W1605207078 @default.
• W2170830738 cites W1655510925 @default.
• W2170830738 cites W1659719610 @default.
• W2170830738 cites W1796359495 @default.
• W2170830738 cites W1814017524 @default.
• W2170830738 cites W1846625983 @default.
• W2170830738 cites W1891596881 @default.
• W2170830738 cites W1965528983 @default.
• W2170830738 cites W1976601347 @default.
• W2170830738 cites W1976887018 @default.
• W2170830738 cites W1977146969 @default.
• W2170830738 cites W1984125372 @default.
• W2170830738 cites W1986342078 @default.
• W2170830738 cites W1987452793 @default.
• W2170830738 cites W1991670386 @default.
• W2170830738 cites W1999272522 @default.
• W2170830738 cites W2010623159 @default.
• W2170830738 cites W2018106813 @default.
• W2170830738 cites W2018643676 @default.
• W2170830738 cites W2018808349 @default.
• W2170830738 cites W2019007714 @default.
• W2170830738 cites W2019231040 @default.
• W2170830738 cites W2019770663 @default.
• W2170830738 cites W2022576045 @default.
• W2170830738 cites W2025701708 @default.
• W2170830738 cites W2026668380 @default.
• W2170830738 cites W2030017358 @default.
• W2170830738 cites W2030482575 @default.
• W2170830738 cites W2031618552 @default.
• W2170830738 cites W2033531531 @default.
• W2170830738 cites W2036270340 @default.
• W2170830738 cites W2036356274 @default.
• W2170830738 cites W2038620796 @default.
• W2170830738 cites W2043501058 @default.
• W2170830738 cites W2044385030 @default.
• W2170830738 cites W2045224288 @default.
• W2170830738 cites W2045245707 @default.
• W2170830738 cites W2045684019 @default.
• W2170830738 cites W2047269867 @default.
• W2170830738 cites W2056360005 @default.
• W2170830738 cites W2057567758 @default.
• W2170830738 cites W2063393407 @default.
• W2170830738 cites W2075915863 @default.
• W2170830738 cites W2076082328 @default.
• W2170830738 cites W2078382230 @default.
• W2170830738 cites W2082173837 @default.
• W2170830738 cites W2083331853 @default.
• W2170830738 cites W2089353735 @default.
• W2170830738 cites W2093736722 @default.
• W2170830738 cites W2097213667 @default.
• W2170830738 cites W2098608499 @default.
• W2170830738 cites W2106440871 @default.
• W2170830738 cites W2117313136 @default.
• W2170830738 cites W2120580958 @default.
• W2170830738 cites W2120628290 @default.
• W2170830738 cites W2124099348 @default.
• W2170830738 cites W2126576562 @default.
• W2170830738 cites W2167567978 @default.
• W2170830738 cites W2171553929 @default.
• W2170830738 cites W2196560244 @default.
• W2170830738 cites W2323622850 @default.
• W2170830738 cites W236267061 @default.
• W2170830738 cites W4234329713 @default.
• W2170830738 doi "https://doi.org/10.1084/jem.185.7.1295" @default.
• W2170830738 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2196253" @default.
• W2170830738 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9104816" @default.
• W2170830738 hasPublicationYear "1997" @default.
• W2170830738 type Work @default.
• W2170830738 sameAs 2170830738 @default.
• W2170830738 citedByCount "183" @default.
• W2170830738 countsByYear W21708307382012 @default.
• W2170830738 countsByYear W21708307382013 @default.
• W2170830738 countsByYear W21708307382014 @default.
• W2170830738 countsByYear W21708307382015 @default.

• next