FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2170837715> ?p ?o ?g. }

• W2170837715 abstract "The aim of this research was to formulate, characterise and assess the feasibility of a novel drug delivery system known as the in situ gelling matrix (ISGM) where a hydrophilic polymer is suspended in a non-aqueous solvent that converts into a gel when injected subcutaneously or intramuscularly thus giving a controlled release matrix for a drug. Although the concept has been patented with claims that this kind of drug delivery is achievable in theory for a wide variety of candidate substances, actual formulation studies for making a commercially viable product for this technology are completely lacking in practice. The research embodied in this thesis addresses this lack. Initial studies involved conducting a biocompatibility study using the HET-CAM (hens egg test - chorioallantoic membrane) test on a range of possible ingredients for the delivery system. The materials deemed biocompatible were then carried through to a screening process where the physical stability of the hydrophilic polymers in non-aqueous solvents was monitored. It was found that the hydrophilic polymers tested sedimented rapidly in the non-aqueous solvents indicating such a system was not physically stable. Consequently, density-inducing or viscosity-inducing agents were added to the non-aqueous solvents to retard the sedimentation rate. The addition of polycarbophil, a viscosity-inducing agent, clearly increased the viscosity of the system. However, undesirable formation of polycarbophil globules occurred during the manufacturing process, which caused batch-to-batch variations in the viscosity of the continuous phase. Various manufacturing methods were tested before arriving at the optimum procedure to prevent globule formation using a high speed dispersion tool. A final physical sedimentation analysis of candidate continuous phases and hydrophilic polymers was conducted for determining the ideal combination of ingredients to use in the system. These investigations finally led to the adoption of an optimum mix of components consisting of 10% (w/w) hydroxypropyl methylcellulose (HPMC) (the hydrophilic polymer) suspended in a continuous phase of propylene glycol (the non-aqueous solvent) containing 0.67% (w/w) polycarbophil (the viscosity inducing agent).Using this mix of components, the in situ gelling matrix system was then subjected to various characterisation studies including infrared (IR), differential scanning calorimetry (DSC), ultraviolet-visible (UV-Vis) spectrophotometry and redispersion studies. The chemical stability of the hydrophilic polymer and the continuous phase (the non-aqueous solvent and polycarbophil) was monitored and were found to be chemically stable over a 9 month period. The feasibility of the in situ gelling matrix technology as a controlled release device was assessed using the drug propranolol. In vitro drug release studies were conducted using a custom-built dissolution apparatus. The effect of various parameters such as the concentration of the hydrophilic gelling agent on the drug release rate…" @default.
• W2170837715 created "2016-06-24" @default.
• W2170837715 creator A5084614386 @default.
• W2170837715 date "2007-01-01" @default.
• W2170837715 modified "2023-09-27" @default.
• W2170837715 title "The Development of a Novel Controlled Release Drug Delivery System" @default.
• W2170837715 cites W102496909 @default.
• W2170837715 cites W104408508 @default.
• W2170837715 cites W144574125 @default.
• W2170837715 cites W1483657800 @default.
• W2170837715 cites W1498424148 @default.
• W2170837715 cites W1508262201 @default.
• W2170837715 cites W1517783166 @default.
• W2170837715 cites W1528435409 @default.
• W2170837715 cites W1561657586 @default.
• W2170837715 cites W181212721 @default.
• W2170837715 cites W183298800 @default.
• W2170837715 cites W1892049510 @default.
• W2170837715 cites W192709718 @default.
• W2170837715 cites W1965662044 @default.
• W2170837715 cites W1966590541 @default.
• W2170837715 cites W1966781049 @default.
• W2170837715 cites W1966908003 @default.
• W2170837715 cites W1967607348 @default.
• W2170837715 cites W1968557592 @default.
• W2170837715 cites W1969176407 @default.
• W2170837715 cites W1969991233 @default.
• W2170837715 cites W1971414598 @default.
• W2170837715 cites W1972499690 @default.
• W2170837715 cites W197368718 @default.
• W2170837715 cites W1973845120 @default.
• W2170837715 cites W1973984178 @default.
• W2170837715 cites W1974371653 @default.
• W2170837715 cites W1975714885 @default.
• W2170837715 cites W1975771159 @default.
• W2170837715 cites W1976284410 @default.
• W2170837715 cites W1977072597 @default.
• W2170837715 cites W1977394499 @default.
• W2170837715 cites W1977861698 @default.
• W2170837715 cites W1979447035 @default.
• W2170837715 cites W1983473009 @default.
• W2170837715 cites W1984212850 @default.
• W2170837715 cites W1986642287 @default.
• W2170837715 cites W1987142721 @default.
• W2170837715 cites W1987212621 @default.
• W2170837715 cites W1987302449 @default.
• W2170837715 cites W1987909976 @default.
• W2170837715 cites W1989248607 @default.
• W2170837715 cites W1990540849 @default.
• W2170837715 cites W1990627164 @default.
• W2170837715 cites W1990817608 @default.
• W2170837715 cites W1991274230 @default.
• W2170837715 cites W1992138503 @default.
• W2170837715 cites W1993524583 @default.
• W2170837715 cites W1993705924 @default.
• W2170837715 cites W1993874682 @default.
• W2170837715 cites W1995201537 @default.
• W2170837715 cites W1997041234 @default.
• W2170837715 cites W1997968074 @default.
• W2170837715 cites W2000789758 @default.
• W2170837715 cites W2000939964 @default.
• W2170837715 cites W2001311709 @default.
• W2170837715 cites W2003086220 @default.
• W2170837715 cites W2003290595 @default.
• W2170837715 cites W2003480886 @default.
• W2170837715 cites W2004001982 @default.
• W2170837715 cites W2004441947 @default.
• W2170837715 cites W2005454227 @default.
• W2170837715 cites W2006491656 @default.
• W2170837715 cites W2009213615 @default.
• W2170837715 cites W2009284087 @default.
• W2170837715 cites W2009841111 @default.
• W2170837715 cites W2010139142 @default.
• W2170837715 cites W2011705653 @default.
• W2170837715 cites W2012708360 @default.
• W2170837715 cites W2013140609 @default.
• W2170837715 cites W2013391543 @default.
• W2170837715 cites W2013442070 @default.
• W2170837715 cites W2013797386 @default.
• W2170837715 cites W2013966452 @default.
• W2170837715 cites W2014307488 @default.
• W2170837715 cites W2016465795 @default.
• W2170837715 cites W2018516685 @default.
• W2170837715 cites W2021327126 @default.
• W2170837715 cites W2024384753 @default.
• W2170837715 cites W2025650682 @default.
• W2170837715 cites W2026730798 @default.
• W2170837715 cites W2027242498 @default.
• W2170837715 cites W2028013051 @default.
• W2170837715 cites W2030014926 @default.
• W2170837715 cites W2034205145 @default.
• W2170837715 cites W2034721710 @default.
• W2170837715 cites W2034753236 @default.
• W2170837715 cites W2035028752 @default.
• W2170837715 cites W2035041613 @default.
• W2170837715 cites W2035859432 @default.
• W2170837715 cites W2038041192 @default.
• W2170837715 cites W2038362173 @default.
• W2170837715 cites W2038412329 @default.
• W2170837715 cites W2038961635 @default.

• next