FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2170848255> ?p ?o ?g. }

• W2170848255 endingPage "8" @default.
• W2170848255 startingPage "472" @default.
• W2170848255 abstract "Radiolabeled RGD peptides that target alpha(v)beta3 integrin are promising tracers for imaging tumor angiogenesis. Integrins and angiogenesis also play important roles in healing of ischemic lesions. Thus, we investigated the biodistribution of radiolabeled RGD and expression of alpha(v) integrin in a mouse model of hindlimb ischemia.125I-3-Iodo-D-Tyr4-cyclo(-Arg-Gly-Asp-D-Tyr-Val-) (125I-c(RGD(I)yV)) was synthesized and tested for endothelial binding. Hindlimb ischemia was induced in ICR mice through femoral artery ablation, and perfusion was measured with laser Doppler blood flowmetry. 125I-c(RGD(I)yV) biodistribution was evaluated in control animals (n = 7) and ischemic models on day 3, 8, or 14 (n = 6 each). Control experiments were performed using a radiolabeled peptide with a scrambled amino acid sequence (125I-GfVGV). Microsections of hindlimb tissue were immunostained for alpha(v) integrin expression and stained with alkaline phosphatase to localize vascular endothelial cells.125I-c(RGD(I)yV) retained specific binding to human umbilical vein endothelial cells. Perfusion in ischemic hindlimbs immediately fell to 10% +/- 4% of contralateral levels and gradually recovered to 22% +/- 11% and 64% +/- 9% on days 8 and 14, respectively. 125I-c(RGD(I)yV) uptake in ischemic muscles significantly increased from a control level of 0.16 +/- 0.05 %ID/g (percentage injected dose per gram of tissue) to 0.85 +/- 0.76 %ID/g at day 3, 0.43 +/- 0.23 %ID/g at day 8, and 0.43 +/- 0.28 %ID/g at day 14 (all P < 0.05). Ischemic muscle-to-lung count ratios had a virtually identical trend: 0.42 +/- 0.25 for controls, 2.34 +/- 1.70 at day 3 (P < 0.02), 1.46 +/- 0.52 at day 8 (P < 0.001), and 1.39 +/- 0.94 at day 14 (P < 0.02). In contrast, uptake of the control peptide in ischemic hindlimbs was not different from that of controls. Immunohistochemistry revealed substantially increased alpha(v) integrin staining in ischemic hindlimb tissue.Radioiodine RGD uptake is significantly enhanced in ischemic hindlimbs of a mouse model, and is accompanied by an increase in alpha(v) integrin expression. Further investigation is thus warranted to illuminate the potential role of radiolabeled RGD for noninvasive monitoring of peripheral ischemic lesions." @default.
• W2170848255 created "2016-06-24" @default.
• W2170848255 creator A5002007788 @default.
• W2170848255 creator A5007611070 @default.
• W2170848255 creator A5026877382 @default.
• W2170848255 creator A5027262365 @default.
• W2170848255 creator A5029864279 @default.
• W2170848255 creator A5044006579 @default.
• W2170848255 creator A5059760054 @default.
• W2170848255 creator A5062828812 @default.
• W2170848255 creator A5071434391 @default.
• W2170848255 creator A5078938100 @default.
• W2170848255 date "2005-03-01" @default.
• W2170848255 modified "2023-10-16" @default.
• W2170848255 title "Radiolabeled RGD uptake and alphav integrin expression is enhanced in ischemic murine hindlimbs." @default.
• W2170848255 cites W161287260 @default.
• W2170848255 cites W1964894126 @default.
• W2170848255 cites W1965295524 @default.
• W2170848255 cites W1970483666 @default.
• W2170848255 cites W1987568997 @default.
• W2170848255 cites W2000000541 @default.
• W2170848255 cites W2003287436 @default.
• W2170848255 cites W2015789556 @default.
• W2170848255 cites W2016688430 @default.
• W2170848255 cites W2026580009 @default.
• W2170848255 cites W2027350697 @default.
• W2170848255 cites W2029146061 @default.
• W2170848255 cites W2029773366 @default.
• W2170848255 cites W2035572527 @default.
• W2170848255 cites W2048326417 @default.
• W2170848255 cites W2062437832 @default.
• W2170848255 cites W2071709259 @default.
• W2170848255 cites W2079351435 @default.
• W2170848255 cites W2100363932 @default.
• W2170848255 cites W2105300288 @default.
• W2170848255 cites W2106776747 @default.
• W2170848255 cites W2110881080 @default.
• W2170848255 cites W2123802560 @default.
• W2170848255 cites W2128559706 @default.
• W2170848255 cites W2132689499 @default.
• W2170848255 cites W2137215170 @default.
• W2170848255 cites W2142401146 @default.
• W2170848255 cites W2142482145 @default.
• W2170848255 cites W2143626424 @default.
• W2170848255 cites W2187755941 @default.
• W2170848255 cites W2264304853 @default.
• W2170848255 cites W2287029392 @default.
• W2170848255 cites W2398689555 @default.
• W2170848255 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15750161" @default.
• W2170848255 hasPublicationYear "2005" @default.
• W2170848255 type Work @default.
• W2170848255 sameAs 2170848255 @default.
• W2170848255 citedByCount "17" @default.
• W2170848255 countsByYear W21708482552013 @default.
• W2170848255 countsByYear W21708482552015 @default.
• W2170848255 countsByYear W21708482552016 @default.
• W2170848255 countsByYear W21708482552018 @default.
• W2170848255 countsByYear W21708482552019 @default.
• W2170848255 countsByYear W21708482552021 @default.
• W2170848255 countsByYear W21708482552022 @default.
• W2170848255 crossrefType "journal-article" @default.
• W2170848255 hasAuthorship W2170848255A5002007788 @default.
• W2170848255 hasAuthorship W2170848255A5007611070 @default.
• W2170848255 hasAuthorship W2170848255A5026877382 @default.
• W2170848255 hasAuthorship W2170848255A5027262365 @default.
• W2170848255 hasAuthorship W2170848255A5029864279 @default.
• W2170848255 hasAuthorship W2170848255A5044006579 @default.
• W2170848255 hasAuthorship W2170848255A5059760054 @default.
• W2170848255 hasAuthorship W2170848255A5062828812 @default.
• W2170848255 hasAuthorship W2170848255A5071434391 @default.
• W2170848255 hasAuthorship W2170848255A5078938100 @default.
• W2170848255 hasConcept C126322002 @default.
• W2170848255 hasConcept C142724271 @default.
• W2170848255 hasConcept C146957229 @default.
• W2170848255 hasConcept C153911025 @default.
• W2170848255 hasConcept C170493617 @default.
• W2170848255 hasConcept C185592680 @default.
• W2170848255 hasConcept C195687474 @default.
• W2170848255 hasConcept C202751555 @default.
• W2170848255 hasConcept C2777411675 @default.
• W2170848255 hasConcept C2777807558 @default.
• W2170848255 hasConcept C2780394083 @default.
• W2170848255 hasConcept C51738704 @default.
• W2170848255 hasConcept C541997718 @default.
• W2170848255 hasConcept C55493867 @default.
• W2170848255 hasConcept C71924100 @default.
• W2170848255 hasConcept C86803240 @default.
• W2170848255 hasConceptScore W2170848255C126322002 @default.
• W2170848255 hasConceptScore W2170848255C142724271 @default.
• W2170848255 hasConceptScore W2170848255C146957229 @default.
• W2170848255 hasConceptScore W2170848255C153911025 @default.
• W2170848255 hasConceptScore W2170848255C170493617 @default.
• W2170848255 hasConceptScore W2170848255C185592680 @default.
• W2170848255 hasConceptScore W2170848255C195687474 @default.
• W2170848255 hasConceptScore W2170848255C202751555 @default.
• W2170848255 hasConceptScore W2170848255C2777411675 @default.
• W2170848255 hasConceptScore W2170848255C2777807558 @default.
• W2170848255 hasConceptScore W2170848255C2780394083 @default.

• next