FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2170852072> ?p ?o ?g. }

• W2170852072 endingPage "760" @default.
• W2170852072 startingPage "747" @default.
• W2170852072 abstract "Objectives: In this study, the authors developed d-α-tocopheryl polyethylene glycol 1000 succinate (vitamin E TPGS or simply TPGS) liposomes and further conjugated them to trastuzumab for controlled and targeted delivery of docetaxel (DTX) as a model hydrophobic drug. Methods: DTX- or coumarin-6-loaded liposomes were prepared by solvent injection method and characterized for size and size distribution, surface charge, surface chemistry and drug encapsulation efficiency and drug release profile. SK-BR-3 cells were employed as an in vitro model for HER2-positive breast cancer and assessed for their cellular uptake and cytotoxicity of the two liposomal formulations. In vivo pharmacokinetics (PK) was investigated in Sprague–Dawley rats. Results: The IC50 value was found to be 20.23 ± 1.95, 3.74 ± 0.98, 0.08 ± 0.4 μg/ml for the marketed preparation of DTX, TPGS liposomes and trastuzumab-conjugated TPGS liposomes, respectively after 24 h incubation with SK-BR-3 cells. In vivo PK experiments showed that i.v. administration of trastuzumab-conjugated liposomes achieved 1.9 and 10 times longer half-life, respectively than PEG-coated liposomes and DTX. The area under the curve (AUC) was increased by 3.47- and 1.728-fold, respectively. Conclusion: The trastuzumab-conjugated vitamin E TPGS-coated liposomes showed greater potential for sustained and targeted chemotherapy in the treatment of HER2 overexpressing breast cancer." @default.
• W2170852072 created "2016-06-24" @default.
• W2170852072 creator A5014817439 @default.
• W2170852072 creator A5032249435 @default.
• W2170852072 creator A5090841972 @default.
• W2170852072 date "2013-03-04" @default.
• W2170852072 modified "2023-10-17" @default.
• W2170852072 title "Trastuzumab-conjugated vitamin E TPGS liposomes for sustained and targeted delivery of docetaxel" @default.
• W2170852072 cites W1967974277 @default.
• W2170852072 cites W1973704310 @default.
• W2170852072 cites W1975825141 @default.
• W2170852072 cites W1983671192 @default.
• W2170852072 cites W1987609206 @default.
• W2170852072 cites W2004759520 @default.
• W2170852072 cites W2013780909 @default.
• W2170852072 cites W2015168077 @default.
• W2170852072 cites W2023245022 @default.
• W2170852072 cites W2025523616 @default.
• W2170852072 cites W2029583431 @default.
• W2170852072 cites W2030955688 @default.
• W2170852072 cites W2031104374 @default.
• W2170852072 cites W2037192290 @default.
• W2170852072 cites W2037653676 @default.
• W2170852072 cites W2042870644 @default.
• W2170852072 cites W2042973822 @default.
• W2170852072 cites W2046785634 @default.
• W2170852072 cites W2046891245 @default.
• W2170852072 cites W2049086737 @default.
• W2170852072 cites W2058343111 @default.
• W2170852072 cites W2067983816 @default.
• W2170852072 cites W2068678383 @default.
• W2170852072 cites W2068956748 @default.
• W2170852072 cites W2080879368 @default.
• W2170852072 cites W2083656439 @default.
• W2170852072 cites W2085363990 @default.
• W2170852072 cites W2087324070 @default.
• W2170852072 cites W2091400260 @default.
• W2170852072 cites W2093495159 @default.
• W2170852072 cites W2127162452 @default.
• W2170852072 cites W2137634849 @default.
• W2170852072 cites W2149765977 @default.
• W2170852072 cites W2154335294 @default.
• W2170852072 cites W2167690957 @default.
• W2170852072 doi "https://doi.org/10.1517/17425247.2013.777425" @default.
• W2170852072 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23458409" @default.
• W2170852072 hasPublicationYear "2013" @default.
• W2170852072 type Work @default.
• W2170852072 sameAs 2170852072 @default.
• W2170852072 citedByCount "63" @default.
• W2170852072 countsByYear W21708520722013 @default.
• W2170852072 countsByYear W21708520722014 @default.
• W2170852072 countsByYear W21708520722015 @default.
• W2170852072 countsByYear W21708520722016 @default.
• W2170852072 countsByYear W21708520722017 @default.
• W2170852072 countsByYear W21708520722018 @default.
• W2170852072 countsByYear W21708520722019 @default.
• W2170852072 countsByYear W21708520722020 @default.
• W2170852072 countsByYear W21708520722021 @default.
• W2170852072 countsByYear W21708520722022 @default.
• W2170852072 countsByYear W21708520722023 @default.
• W2170852072 crossrefType "journal-article" @default.
• W2170852072 hasAuthorship W2170852072A5014817439 @default.
• W2170852072 hasAuthorship W2170852072A5032249435 @default.
• W2170852072 hasAuthorship W2170852072A5090841972 @default.
• W2170852072 hasConcept C10138342 @default.
• W2170852072 hasConcept C109316439 @default.
• W2170852072 hasConcept C112705442 @default.
• W2170852072 hasConcept C121608353 @default.
• W2170852072 hasConcept C126322002 @default.
• W2170852072 hasConcept C150903083 @default.
• W2170852072 hasConcept C162324750 @default.
• W2170852072 hasConcept C178790620 @default.
• W2170852072 hasConcept C181389837 @default.
• W2170852072 hasConcept C185154212 @default.
• W2170852072 hasConcept C185592680 @default.
• W2170852072 hasConcept C202751555 @default.
• W2170852072 hasConcept C207001950 @default.
• W2170852072 hasConcept C2776694085 @default.
• W2170852072 hasConcept C2776964284 @default.
• W2170852072 hasConcept C2777752497 @default.
• W2170852072 hasConcept C2779786085 @default.
• W2170852072 hasConcept C2779820397 @default.
• W2170852072 hasConcept C2781190966 @default.
• W2170852072 hasConcept C530470458 @default.
• W2170852072 hasConcept C54400483 @default.
• W2170852072 hasConcept C55493867 @default.
• W2170852072 hasConcept C71924100 @default.
• W2170852072 hasConcept C86803240 @default.
• W2170852072 hasConcept C98274493 @default.
• W2170852072 hasConceptScore W2170852072C10138342 @default.
• W2170852072 hasConceptScore W2170852072C109316439 @default.
• W2170852072 hasConceptScore W2170852072C112705442 @default.
• W2170852072 hasConceptScore W2170852072C121608353 @default.
• W2170852072 hasConceptScore W2170852072C126322002 @default.
• W2170852072 hasConceptScore W2170852072C150903083 @default.
• W2170852072 hasConceptScore W2170852072C162324750 @default.
• W2170852072 hasConceptScore W2170852072C178790620 @default.
• W2170852072 hasConceptScore W2170852072C181389837 @default.

• next