FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2170852425> ?p ?o ?g. }

• W2170852425 endingPage "1562" @default.
• W2170852425 startingPage "1556" @default.
• W2170852425 abstract "Urocortin is a novel cardioprotective agent that can protect cardiac myocytes from the damaging effects of ischemia/reperfusion both in culture and in the intact heart and is effective when given at reperfusion.We have analyzed global changes in gene expression in cardiac myocytes after urocortin treatment using gene chip technology. We report that urocortin specifically induces enhanced expression of the Kir 6.1 cardiac potassium channel subunit. On the basis of this finding, we showed that the cardioprotective effect of urocortin both in isolated cardiac cells and in the intact heart is specifically blocked by both generalized and mitochondrial-specific K(ATP) channel blockers, whereas the cardioprotective effect of cardiotrophin-1 is unaffected. Conversely, inhibiting the Kir 6.1 channel subunit greatly enhances cardiac cell death after ischemia.This is, to our knowledge, the first report of the altered expression of a K(ATP) channel subunit induced by a cardioprotective agent and demonstrates that K(ATP) channel opening is essential for the effect of this novel cardioprotective agent." @default.
• W2170852425 created "2016-06-24" @default.
• W2170852425 creator A5002956062 @default.
• W2170852425 creator A5004402387 @default.
• W2170852425 creator A5021367268 @default.
• W2170852425 creator A5024585960 @default.
• W2170852425 creator A5028025117 @default.
• W2170852425 creator A5032096052 @default.
• W2170852425 creator A5052972876 @default.
• W2170852425 creator A5057240577 @default.
• W2170852425 creator A5062655570 @default.
• W2170852425 creator A5069835907 @default.
• W2170852425 creator A5080578374 @default.
• W2170852425 creator A5081968740 @default.
• W2170852425 date "2002-09-17" @default.
• W2170852425 modified "2023-09-27" @default.
• W2170852425 title "K _ATP Channel Gene Expression Is Induced by Urocortin and Mediates Its Cardioprotective Effect" @default.
• W2170852425 cites W1814497677 @default.
• W2170852425 cites W1969388350 @default.
• W2170852425 cites W1972400285 @default.
• W2170852425 cites W1972680803 @default.
• W2170852425 cites W1976518569 @default.
• W2170852425 cites W1983347237 @default.
• W2170852425 cites W1989918919 @default.
• W2170852425 cites W1998016052 @default.
• W2170852425 cites W2014376812 @default.
• W2170852425 cites W2020858778 @default.
• W2170852425 cites W2031633258 @default.
• W2170852425 cites W2054550208 @default.
• W2170852425 cites W2059461347 @default.
• W2170852425 cites W2061988480 @default.
• W2170852425 cites W2070385915 @default.
• W2170852425 cites W2070429028 @default.
• W2170852425 cites W2079071443 @default.
• W2170852425 cites W2080784615 @default.
• W2170852425 cites W2081207681 @default.
• W2170852425 cites W2085434507 @default.
• W2170852425 cites W2133141498 @default.
• W2170852425 cites W2144252058 @default.
• W2170852425 doi "https://doi.org/10.1161/01.cir.0000028424.02525.ae" @default.
• W2170852425 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12234964" @default.
• W2170852425 hasPublicationYear "2002" @default.
• W2170852425 type Work @default.
• W2170852425 sameAs 2170852425 @default.
• W2170852425 citedByCount "68" @default.
• W2170852425 countsByYear W21708524252012 @default.
• W2170852425 countsByYear W21708524252013 @default.
• W2170852425 countsByYear W21708524252014 @default.
• W2170852425 countsByYear W21708524252015 @default.
• W2170852425 countsByYear W21708524252017 @default.
• W2170852425 countsByYear W21708524252018 @default.
• W2170852425 countsByYear W21708524252019 @default.
• W2170852425 countsByYear W21708524252021 @default.
• W2170852425 crossrefType "journal-article" @default.
• W2170852425 hasAuthorship W2170852425A5002956062 @default.
• W2170852425 hasAuthorship W2170852425A5004402387 @default.
• W2170852425 hasAuthorship W2170852425A5021367268 @default.
• W2170852425 hasAuthorship W2170852425A5024585960 @default.
• W2170852425 hasAuthorship W2170852425A5028025117 @default.
• W2170852425 hasAuthorship W2170852425A5032096052 @default.
• W2170852425 hasAuthorship W2170852425A5052972876 @default.
• W2170852425 hasAuthorship W2170852425A5057240577 @default.
• W2170852425 hasAuthorship W2170852425A5062655570 @default.
• W2170852425 hasAuthorship W2170852425A5069835907 @default.
• W2170852425 hasAuthorship W2170852425A5080578374 @default.
• W2170852425 hasAuthorship W2170852425A5081968740 @default.
• W2170852425 hasBestOaLocation W21708524251 @default.
• W2170852425 hasConcept C104292427 @default.
• W2170852425 hasConcept C104317684 @default.
• W2170852425 hasConcept C126322002 @default.
• W2170852425 hasConcept C170493617 @default.
• W2170852425 hasConcept C207200792 @default.
• W2170852425 hasConcept C2777688879 @default.
• W2170852425 hasConcept C55493867 @default.
• W2170852425 hasConcept C71924100 @default.
• W2170852425 hasConcept C83743174 @default.
• W2170852425 hasConcept C86803240 @default.
• W2170852425 hasConcept C98274493 @default.
• W2170852425 hasConceptScore W2170852425C104292427 @default.
• W2170852425 hasConceptScore W2170852425C104317684 @default.
• W2170852425 hasConceptScore W2170852425C126322002 @default.
• W2170852425 hasConceptScore W2170852425C170493617 @default.
• W2170852425 hasConceptScore W2170852425C207200792 @default.
• W2170852425 hasConceptScore W2170852425C2777688879 @default.
• W2170852425 hasConceptScore W2170852425C55493867 @default.
• W2170852425 hasConceptScore W2170852425C71924100 @default.
• W2170852425 hasConceptScore W2170852425C83743174 @default.
• W2170852425 hasConceptScore W2170852425C86803240 @default.
• W2170852425 hasConceptScore W2170852425C98274493 @default.
• W2170852425 hasIssue "12" @default.
• W2170852425 hasLocation W21708524251 @default.
• W2170852425 hasLocation W21708524252 @default.
• W2170852425 hasLocation W21708524253 @default.
• W2170852425 hasLocation W21708524254 @default.
• W2170852425 hasOpenAccess W2170852425 @default.
• W2170852425 hasPrimaryLocation W21708524251 @default.
• W2170852425 hasRelatedWork W1983234968 @default.
• W2170852425 hasRelatedWork W1996977807 @default.

• next