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- W2170857776 endingPage "569" @default.
- W2170857776 startingPage "557" @default.
- W2170857776 abstract "Soma-to-germline feedback is forbidden under the neo-Darwinian paradigm. Nevertheless, there is a growing realization it occurs frequently in immunoglobulin (Ig) variable (V) region genes. This is a surprising development. It arises from a most unlikely source in light of the exposure of co-author EJS to the haplotype data of RL Dawkins and others on the polymorphism of the Major Histocompatibility Complex, which is generally assumed to be the most polymorphic region in the genome (spanning ∼4 Mb). The comparison between the magnitude of MHC polymorphism with estimates for the human heavy chain immunoglobulin V locus (spanning ∼1 Mb), suggests IGHV could be many orders of magnitude more polymorphic than the MHC. This conclusion needs airing in the literature as it implies generational churn and soma-to-germline gene feedback. Pedigree-based experimental strategies to resolve the IGHV issue are outlined." @default.
- W2170857776 created "2016-06-24" @default.
- W2170857776 creator A5049693186 @default.
- W2170857776 creator A5075370774 @default.
- W2170857776 date "2015-03-23" @default.
- W2170857776 modified "2023-10-09" @default.
- W2170857776 title "Soma-to-germline feedback is implied by the extreme polymorphism at IGHV relative to MHC" @default.
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