FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2170858457> ?p ?o ?g. }

• W2170858457 endingPage "804" @default.
• W2170858457 startingPage "799" @default.
• W2170858457 abstract "To centrally assess the safety, efficacy, and 6-year follow-up of recombinant adenovirus-p53 (rAd-p53) combined with radiotherapy (RT) for patients with nasopharyngeal carcinoma (NPC).A randomized controlled clinical study on rAd-p53 combined with RT in 42 patients with NPC was compared with a control group of 40 patients with NPC treated with RT alone. In the group receiving rAd-p53 combined with RT, rAd-p53 was intratumorally injected once a week for 8 weeks. Concurrent RT (70 Gy in 35 fractions) was given to the nasopharyngeal tumor and neck lymph node. Patients and tumors were monitored for adverse events and responses.rAd-p53-specific p53 mRNA was detected in postinjection of rAd-p53 biopsies from 16 (94.1%) of 17 patients. Upregulation of p21/WAF1 and Bax and downregulation of vascular endothelial growth factor were observed in postinjection tumor biopsy. Complete response rate in the group receiving rAd-p53 combined with RT was observed at 2.73 times that of the group receiving RT alone (66.7% v 24.4%). Six-year follow-up data showed that rAd-p53 significantly increased the 5-year locoregional tumor control rate by 25.3% for patients with NPC treated with irradiation (P = .002). The 5-year overall survival rate and 5-year disease-free survival rate of the group receiving rAd-p53 combined with RT were 7.5% (P = .34) and 11.7% (P = .21) higher than those of the group receiving RT alone. No dose-limiting toxicity or adverse events appeared, except for transient fever after rAd-p53 administration.In patients with NPC, rAd-p53 was safe and biologically active. Our results indicated that rAd-p53 improves radiotherapeutic tumor control and survival rate in patients with NPC." @default.
• W2170858457 created "2016-06-24" @default.
• W2170858457 creator A5009761511 @default.
• W2170858457 creator A5021683203 @default.
• W2170858457 creator A5030377129 @default.
• W2170858457 creator A5032929941 @default.
• W2170858457 creator A5069224733 @default.
• W2170858457 creator A5071771834 @default.
• W2170858457 creator A5077453513 @default.
• W2170858457 creator A5078550219 @default.
• W2170858457 creator A5080078676 @default.
• W2170858457 creator A5082461403 @default.
• W2170858457 creator A5083147929 @default.
• W2170858457 date "2009-02-10" @default.
• W2170858457 modified "2023-09-26" @default.
• W2170858457 title "Effect of Recombinant Adenovirus-p53 Combined With Radiotherapy on Long-Term Prognosis of Advanced Nasopharyngeal Carcinoma" @default.
• W2170858457 cites W1976784977 @default.
• W2170858457 cites W1994038048 @default.
• W2170858457 cites W1996474776 @default.
• W2170858457 cites W2008231487 @default.
• W2170858457 cites W2010861323 @default.
• W2170858457 cites W2013072008 @default.
• W2170858457 cites W2014033755 @default.
• W2170858457 cites W2021006762 @default.
• W2170858457 cites W2063626248 @default.
• W2170858457 cites W2063717118 @default.
• W2170858457 cites W2079439493 @default.
• W2170858457 cites W2081894694 @default.
• W2170858457 cites W2083431183 @default.
• W2170858457 cites W2125048328 @default.
• W2170858457 cites W2160964011 @default.
• W2170858457 cites W2244995601 @default.
• W2170858457 doi "https://doi.org/10.1200/jco.2008.18.9670" @default.
• W2170858457 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19103729" @default.
• W2170858457 hasPublicationYear "2009" @default.
• W2170858457 type Work @default.
• W2170858457 sameAs 2170858457 @default.
• W2170858457 citedByCount "111" @default.
• W2170858457 countsByYear W21708584572012 @default.
• W2170858457 countsByYear W21708584572013 @default.
• W2170858457 countsByYear W21708584572014 @default.
• W2170858457 countsByYear W21708584572015 @default.
• W2170858457 countsByYear W21708584572016 @default.
• W2170858457 countsByYear W21708584572017 @default.
• W2170858457 countsByYear W21708584572018 @default.
• W2170858457 countsByYear W21708584572019 @default.
• W2170858457 countsByYear W21708584572020 @default.
• W2170858457 countsByYear W21708584572021 @default.
• W2170858457 countsByYear W21708584572022 @default.
• W2170858457 countsByYear W21708584572023 @default.
• W2170858457 crossrefType "journal-article" @default.
• W2170858457 hasAuthorship W2170858457A5009761511 @default.
• W2170858457 hasAuthorship W2170858457A5021683203 @default.
• W2170858457 hasAuthorship W2170858457A5030377129 @default.
• W2170858457 hasAuthorship W2170858457A5032929941 @default.
• W2170858457 hasAuthorship W2170858457A5069224733 @default.
• W2170858457 hasAuthorship W2170858457A5071771834 @default.
• W2170858457 hasAuthorship W2170858457A5077453513 @default.
• W2170858457 hasAuthorship W2170858457A5078550219 @default.
• W2170858457 hasAuthorship W2170858457A5080078676 @default.
• W2170858457 hasAuthorship W2170858457A5082461403 @default.
• W2170858457 hasAuthorship W2170858457A5083147929 @default.
• W2170858457 hasBestOaLocation W21708584571 @default.
• W2170858457 hasConcept C104317684 @default.
• W2170858457 hasConcept C126322002 @default.
• W2170858457 hasConcept C126894567 @default.
• W2170858457 hasConcept C127561419 @default.
• W2170858457 hasConcept C143998085 @default.
• W2170858457 hasConcept C197934379 @default.
• W2170858457 hasConcept C2777546739 @default.
• W2170858457 hasConcept C2778997737 @default.
• W2170858457 hasConcept C2780849966 @default.
• W2170858457 hasConcept C509974204 @default.
• W2170858457 hasConcept C55493867 @default.
• W2170858457 hasConcept C71924100 @default.
• W2170858457 hasConcept C86803240 @default.
• W2170858457 hasConcept C90924648 @default.
• W2170858457 hasConceptScore W2170858457C104317684 @default.
• W2170858457 hasConceptScore W2170858457C126322002 @default.
• W2170858457 hasConceptScore W2170858457C126894567 @default.
• W2170858457 hasConceptScore W2170858457C127561419 @default.
• W2170858457 hasConceptScore W2170858457C143998085 @default.
• W2170858457 hasConceptScore W2170858457C197934379 @default.
• W2170858457 hasConceptScore W2170858457C2777546739 @default.
• W2170858457 hasConceptScore W2170858457C2778997737 @default.
• W2170858457 hasConceptScore W2170858457C2780849966 @default.
• W2170858457 hasConceptScore W2170858457C509974204 @default.
• W2170858457 hasConceptScore W2170858457C55493867 @default.
• W2170858457 hasConceptScore W2170858457C71924100 @default.
• W2170858457 hasConceptScore W2170858457C86803240 @default.
• W2170858457 hasConceptScore W2170858457C90924648 @default.
• W2170858457 hasIssue "5" @default.
• W2170858457 hasLocation W21708584571 @default.
• W2170858457 hasLocation W21708584572 @default.
• W2170858457 hasOpenAccess W2170858457 @default.
• W2170858457 hasPrimaryLocation W21708584571 @default.
• W2170858457 hasRelatedWork W2197028304 @default.
• W2170858457 hasRelatedWork W2359240367 @default.

• next